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[EXPIRED] The Capital Region of Copenhagen is looking for a Postdoctoral / Research fellow in advanced 7T MRI and MRS neuroscience applications

If you are a team-oriented MR researcher eager to unleash the full potentials of 7T ultra-high field MRI and MRS through novel software and hardware solutions, then you might be the person we are looking for!

As a researcher at the Danish Research Centre for Magnetic Resonance (DRCMR) you will support new and ongoing 7T studies and have the freedom to develop novel MRI/MRS sequences, hardware and processing methods primarily targeting neuroscientific applications.

You will be working closely with a multidisciplinary team of engineers, physicists, biomedical and clinical experts, who are developing and applying exciting and cutting-edge microstructural and X-nuclei imaging techniques for 7T. You will be part of the Ultra-high field MR group (www.drcmr.dk/7t). We have a Philips 7T research only scanner with 2- and 8-channel transmit, 32 receive and 64 shim channels in addition to the standard 3rd order shim.

DRCMR is one of the leading research centers for biomedical MRI in Europe (www.drcmr.dk). Our interdisciplinary research is geared to triangulate between MR physics, basic physiology, and clinical research. Approximately 70 researchers from a diverse range of disciplines work together to pursue basic and clinically applied MR research with a focus on structural, functional, and metabolic MRI of the human brain and its disorders. Collaboration is key at DRCMR – we do not expect any researcher to be able to do everything alone, but we expect everyone to be interested in sharing knowledge with colleagues.

The DRCMR is embedded in the Department of Radiology and Nuclear Medicine, a large diagnostic imaging department including all biomedical imaging modalities at Copenhagen University Hospital Hvidovre. The hospital also has strong collaborative links with the Technical University of Denmark and is part of the newly established organizational framework, The Technical University Hospital of Greater Copenhagen. DRCMR has close interaction with clinicians and radiologists and a state-of-the-art MR-research infrastructure, which includes a pre-clinical 7T MR scanner, six whole-body MR scanners (one 7T, four 3T and one 1.5T scanners), a hardware workshop and laboratory, a neuropsychology laboratory, an EEG laboratory, and two laboratories for non-invasive brain stimulation.  The 7T is a national research infrastructure, serving internal and external users across Denmark.

Your profile:

You are a team-oriented, creative and enthusiastic researcher with:

  • A PhD degree in engineering, physics, biomedical sciences or a related field.
  • At least 2-3 years of doctoral and/or postdoctoral experience within ultra-high field MRI (preferably on Philips systems).
  • A clear interest in MRI/MRS acquisition, reconstruction and image analysis.
  • Excellent knowledge of MR physics and programming skills in C/C++, MATLAB or Python.
  • Ideally experience in MR sequence programming (preferably on Philips MR system).
  • Affinity with medical applications.
  • Strong communication and collaborative skills.

Your tasks:

  • To work directly with other scientists to ensure that our research studies take full advantage of the 7T MR scanner by maximizing the clinical information available in the multi-parametric MRI images (structural, functional and other quantitative read-outs) and MRS including deuterium spectroscopy.
  • Assist with the daily operations of the 7T scanners, which encompasses tasks such as conducting MRI safety trainings and quality control of scanner performance.
  • To develop novel sequences and data analysis methods, and possibly new hardware designs.
  • To advance the field through your own research.
  • To engage in internal education, grant writing, knowledge dissemination, and publication of results in international, recognized scientific journals.

Your position:

You will be employed for a four-year period at the DRCMR and join the ultra-high field MR group.

 

Selected Publications

Atudorei M, del Agua Villa C, Gether U, Cenci MA, Siebner HR and Rickhag M (2025) Bilateral chemogenetic activation of Intratelencephalic Neurons in Motor Cortex Reduces Spontaneous Locomotor Activity in Mice. Neurobiology of Disease. 2024 Nov 26:106755. doi: 10.1016/j.nbd.2024.106755)

Del Agua Villa C, Atudorei M, Siebner HR and Rickhag M (2024) Pharmacological Targeting of Dopamine D1 or D2 Receptors Evokes a Rapid-Onset, Distinct Parkinsonian Motor Phenotype in Mice. European Journal of Neuroscience. 2024 Dec 3. doi: 10.1111/ejn.16622)

Apuschkin M, Støier JF, Skov L, Ejdrup A, Chan Andersen R, Dmytriyeva O,  Sørensen AT, Egerod K, Holst B,  Rickhag M,  Schwartz T and Gether U (2024) An atlas of GPCRs in dopamine neurons: identification of the free fatty acid receptor-4 (FFAR4) as a regulator of food and water intake. (2024 Jul 23;43(7):114509. doi: 10.1016 - Cell Reports)

Herborg F, Konrad L, Pugh C, Delignat-Lavaud B, Friis Rather C, , Awadallah N, Pino Reyes J, Berlin F, Rickhag M, Torres G, Holst B, Trudeau LE and Gether U (2023) Mouse model of atypical DAT deficiency syndrome uncovers dopamine dysfunction associated with parkinsonism and psychiatric disease. bioRxiv, 2023.08. 17.553695

Sørensen G, Rickhag M, Leo D, Lycas MD, Ridderstrøm PH, Weikop P, Lilja JH, Rifes P, Herborg F, Woldbye D, Wörtwein G, Gainetdinov RR, Fink-Jensen A, Gether U, Disruption of the PDZ-domain binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis and reward motivation, Journal of Biological Chemistry (2021), doi: https:// doi.org/10.1016/j.jbc.2021.101361.

Herborg F, Jensen K, Tolstoy S, Arends N, Posselt L, Shekar A, Aguilar J, Lund V, Erreger K, Rickhag M, Lycas M, Lonsdale M, Rahbek-Clemmensen T, Sørensen A, Newman A, Løkkegaard A, Kjærulff O, Hansen T, Møller L, Matthies H, Galli A, Hjermind L, Gether U (2021) Dominant-negative actions of a dopamine transporter variant identified in patients with parkinsonism and neuropsychiatric disease. Journal of Clinical Investigation Insight 2021 Aug 10:151496

Christensen M, Nørr SE, Gether U and Rickhag M (2021). Direct-Pathway Spiny Projection Neuron Inhibition Evokes Transient Circuit Imbalance Manifested as Rotational Behavior.  Neuroscience. 2021 Jan 15;453:32-42

Ciriachi C, Svane-Petersen D and Rickhag M (2019). Genetic Tools to Study Complexity of Striatal Function. Journal of Neuroscience Research. 2019 Oct;97(10):1181-1193

DiCarlo GE, Aguilar JI, Matthies HJ, Harrison FE, Bundschuh KE, West A, Hashemi P, Herborg F, Rickhag M, Chen H, Gether U, Wallace MT, Galli A (2019). Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors. Journal of Clinical Investigation. 2019 May 16;129(8):3407-3419.

Bay Kønig A, Ciriachi C, Gether U and Rickhag M (2019). Chemogenetic Targeting of Dorsomedial Direct-Pathway Striatal Projection Neurons Selectively Elicits Rotational Behavior in Mice. Neuroscience. 2019 Mar 1; 401:106-116

Runegaard A, Sørensen AT, Fitzpatrick C, Jørgensen S, Petersen A, Hansen N, Weikop P, Andreasen J, Mikkelsen J, Perrier JF, Woldbye D, Rickhag M, Wörtwein G and Gether U (2018). Locomotor- and reward-enhancing effects of cocaine are differentially regulated by chemogenetic stimulation of Gi-signaling in dopaminergic neurons. eNeuro: 0345-17.2018 

Jensen K, Sørensen G, Dencker D, Owens W, Rahbek-Clemmensen T, Brett Lever M, Runegaard A, Riis Christensen N, Weikop P, Wörtwein G, Fink-Jensen A, Madsen K, Daws L, Gether U and Rickhag M (2018). PICK1-deficient mice exhibit impaired response to cocaine and dysregulated dopamine homeostasis. eNeuro:0422-17.2018

Jensen KL, Runegaard AH, Weikop P, Gether U and Rickhag M (2017). Assessment of Dopaminergic Homeostasis in Mice by Use of High-Performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake. Journal of Visualized Experiments, 127, e56093, doi:10.3791/56093

Runegaard AH, Jensen KL, Fitzpatrick CM, Dencker D, Weikop P, Gether U and Rickhag M (2017). Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice. European Journal of Neuroscience, 45(1):121-128

Apuschkin M, Stilling S, Rahbek-Clemmensen T, Sørensen G, Fortin G, Herborg Hansen F, Eriksen J, Trudeau LE, Egerod K, Gether U and Rickhag M (2015). A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity. European Journal of Neuroscience 42: 2438-2454

Steinkellner T, Montgomery TR, Hofmaier T, Kudlacek O, Yang JW, Rickhag M, Jung G, Lubec G, Gether U, Freissmuth M, Sitte HH (2015). Amphetamine action at the cocaine- and antidepressant sensitive serotonin transporter is modulated by αCaMKII. Journal of Neuroscience 27;35(21):8258-71

Steinkellner T, Mus L, Eisenrauch B, Constantinescu A, Leo D, Konrad L, Rickhag M, Sørensen G, Efimova EV, Kong E, Willeit M, Sotnikova TD, Kudlacek O, Gether U, Freissmuth M, Pollak DD, Gainetdinov RR, Sitte HH (2014). In vivo amphetamine action is contingent on alpha-CaMKII. Neuropsychopharmacology 39(11): 2681-93

Rickhag M, Owens WA, Winkler MT, Strandfelt KN, Rathje M, Andresen B, Sørensen G, Madsen KL, Jørgensen TN, Wörtwein G, Woldbye DP, Sitte H, Daws LC and Gether U (2013).  Membrane permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release. Journal of Biological Chemistry 20;288(38): 27534-44

Rickhag M, Hansen FH, Sørensen G, Strandfelt KN, Andresen B, Gotfryd K, Madsen KL, Vestergaard-Klewe I, Ammendrup-Johnsen I, Eriksen J, Newman AH, Füchtbauer EM, Gomeza J, Woldbye DP, Wörtwein G and Gether U (2013). A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter. Nature Communications 4:1580

Holst B, Madsen KL, Jansen AM, Jin C, Rickhag M, Lund VK, Jensen M, Bhatia V, Sørensen G, Madsen AN, Xue Z, Møller SK, Woldbye DP, Qvortrup K, Huganir R, Stamou D, Kjærulff O and Gether U. (2013). PICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose Tolerance. PLoS Biology 11(4):e1001542

Ruscher K, Shamloo M, Rickhag M, Ladunga I, Soriano L, Gisselsson L, Toresson H, Ruslim-Litrus L, Oksenberg D, Urfer R, Johansson BB, Nikolich K and Wieloch T  (2011). The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke. Brain 134(3): 732-46

Ruscher K, Johannesson E, Brugiere E, Erickson A, Rickhag M and Wieloch T (2009). Enriched enviroment reduces apolipoprotein E (ApoE) in reactive astrocytes and attenuates inflammation of the peri-infarct tissue after experimental stroke. Journal of Cerebral Blood Flow and Metabolism 29(11): 1796-805

Ruscher K, Johannesson E, Rickhag M and Wieloch T (2009). Spatio-temporal changes of apolipoprotein E (ApoE) in the rat brain after experimental stroke. Enriched housing condition attenuates ApoE expression. Journal of Cerebral Blood Flow and Metabolism 29, S267-S267

Rickhag M, Deierborg T, Patel S, Ruscher K and Wieloch T (2008). Apolipoprotein D is elevated in oligodendrocytes in the peri-infarct region after experimental stroke – Influence of enriched environment. Journal of Cerebral Blood Flow and Metabolism 28(3): 551-62;

Rickhag M, Teilum M and Wieloch T (2007). Rapid and long-term induction of effector immediate-early genes (BDNF, Neuritin and Arc) in peri-infarct cortex and dentate gyrus after ischemic injury in rat brain. Brain Research. 1151: 203-210

Shamloo M, Soriano L, von Schack D, Rickhag M, Chin DJ, Gonzalez-Zulueta M, Gido G, Urfer R, Wieloch T and Nikolich K (2006). Npas4, a novel helix-loop-helix PAS domain protein, is regulated in response to cerebral ischemia. European Journal of Neuroscience. 24(10): 2705-2720

Takao K, Rickhag M, Hegardt C, Oredsson S and Persson L (2006). Induction of apoptotic cell death by putrescine. Int J Biochem Cell Biol. 38(4): 621-8

Rickhag M, Wieloch T, Gidö G, Elmer E, Krogh M, Murray J, Lohr S, Bitter H, Chin DJ, von Schack D, Shamloo M and Nikolich K (2006). Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia-induced gene expression patterns, and reveals a biphasic activation of genes in surviving tissue. Journal of Neurochemistry. 96(1): 14-29 

Urfer R, Rickhag M, Oksenberg D, Shamloo M, Lohr S, Murray J, Krogh M, Johansson B, Nikolich K, Wieloch T (2005). A new approach to enhancement of functional recovery after stroke by genomics analysis of the enriched environment model. Stroke. 36(2): 427-428

Group Members

Mattias Rickhag

Group Leader

Hartwig R. Siebner

Mihai Atudorei

Show all group members (4)

External Collaborators

Professor Angela Cenci Nilsson
Lund University, Sweden

Professor Ulrik Gether
University of Copenhagen, Denmark

Professor Gilad Silberberg
Karolinska Institutet, Sweden