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ADAptive and Precise brain-circuit Targeting in Parkinson’s disease

  • Funded by: The Lundbeck Foundation

ADAPT-PD (ADAptive and Precise brain-circuit Targeting in Parkinson’s disease) is a collaborative project headed by Hartwig Siebner and funded by the Lundbeck Foundation. ADAPT-PD is a collaboration between three sites: DRCMR - Copenhagen, Charité - Universitätsmedizin Berlin, and Lund University - Department of Experimental Medical Science. Furthermore, the Copenhagen site at DRCMR has a close collaboration with the Department of Neurology at Copenhagen University Hospital Bispebjerg.

Our research focuses on investigating dysfunctional circuit dynamics in cortico-basal ganglia (CBG) projections to improve motor and non-motor function in Parkinson´s disease using a multi-modal approach. Invasive recordings and optogenetic stimulation in rodent models of PD as well as invasive electrophysiologic recordings and non-invasive brain mapping in patients will yield novel insights into critical CBG circuit features that constitute candidate targets for ADAPT.

ADAPT PD hjemmeside billede 1

Figure legend: Each site focuses on a different stimulation technique. 

These lines of research will inform the optimization of transcranial and deep brain stimulation in PD patients and be used to fine tune ADAPT in space and time. ADAPT will greatly advance the mechanistic understanding of CBG circuit dynamics in health and PD and create a powerful hub for causal brain circuit discovery, paving the way for personalized device-based neurostimulation, with therapeutic implications beyond PD.


ADAPT PD hjemmeside billede 2

DRCMR Members

Hartwig R. Siebner

Group Leader

David Meder

Lasse Christiansen

Show all group members (11)

External Members


Annemette Løkkegaard
Department of Clinical Medicine
Bispebjerg University Hospital

Andrea Kühn
Movement Disorders and Neuromodulation Section
Charité – Universitätsmedizin Berlin

Angela Cenci Nilsson
Department of Experimental Medical Science
Lund University