Healthy Ageing

 

The vision for the Healthy Aging intervention group is to identify and to optimise sustainable interventional strategies for improved or maintained brain health throughout the lifespan. The mission is to conduct interdisciplinary population-based neuroscience research that provides unique insights into the neuro-cognitive mechanisms of brain and cognitive aging, with a particular emphasis on novel interventions for neuro-enhancement.

Particular focus is on life-style factors, for example physical activity, and by combining advanced brain mapping techniques with extensive behavioral testing we are starting to understand the neural and behavioral effects. In the future, we aim to also include physiologically tailored brain stimulation techniques, for example transcranial alternating current stimulation (TACS), as a potential interventional strategy for neuro-enhancement in aging. We also aim to move further towards understanding motor control in aging, with particular focus on the interplay between cognitive and motor performances. In all our projects, we strive for high academic standards, innovative methods and techniques, and an ambitious, fun and diverse work environment.

Key projects

LISA

The Live active healthy ageing (LISA) study is a 1-year physical training intervention comparing moderate with high intensity resistance training. The study includes 450 community-dwelling healthy individuals aged 62-70 years, and besides MRI scans of the brain also physical and cognitive assessments are performed. The study was initiated with Bispebjerg Hospital and Center for Healthy Aging, University of Copenhagen. The long-term follow-ups (2-10 years) will provide possibilities to track individual late-life aging trajectories.

7T Lifespan

In this project we take advantage of the ultra-high field-strength of 7T and examine how brain metabolites differs across the lifespan. We further aim to link neuro-metabolites to other aging sensitive biomarkers for example cognitive functions and biomarkers in blood.

Lifebrain; Healthy minds from 0-100 years: Optimising the use of European brain imaging cohorts: 

The LISA study is part of the Lifebrain, a European consortium coordinated by the University of Oslo, consisting of 14 partners (https://www.drcmr.dk/lifebrain). Lifebrain was initiated in 2017 and aims (i) to establish a solid foundation of knowledge for understanding how brain, cognitive and mental health can be optimized through the lifespan and (ii) to identify determinants of brain, cognitive and mental health at different stages of life by creating a large database of detailed information about brain imaging relating to cognitive function, mental health, and genetics. Lifebrain incorporates more than 5000 individual participants and exceeds 27.000 examinations in total.

We have close collaboration with other groups at DRCMR, with local groups across Copenhagen, as well as international research centers. We are always looking for talented, enthusiastic and motivated group members, so if you have an interest in interventions and lifespan brain imaging, do not hesitate to contact us.

Selected Publications

Lind, A., Boraxbekk, C.J., Petersen, E.T., Paulsson, O., Siebner, H., & Marsman, A. (2020). Regional myo-inositol, creatine and choline levels are higher at older age and scale negatively with visuo-spatial working memory: A cross-sectional proton MR spectroscopy study at 7 tesla on normal cognitive ageing. Journal of Neuroscience, 40(42), 8149-8159.

Nyberg, L., Boraxbekk, C.J., Eriksson Sörman, D., Hansson, P., Herlitz, A., Kauppi, K., Ljungberg, J.K., Lövheim, H., Lundquist, A., Nordin Adolfsson, A., Oudin, A., Pudas, S., Rönnlund, M., Stiernstedt, M., Sundström, A., & Adolfsson, R. (2020). Biological and environmental predictors of heterogeneity in neurocognitive ageing: Evidence from Betula and other longitudinal studies. Ageing Research Reviews.

Gylling AT, Bloch-Ibenfeldt M, Eriksen CS, Ziegler AK, Wimmelmann CL, Baekgaard M, Boraxbekk CJ, Siebner HR, Mortensen EL, & Kjaer M. (2020). Maintenance of muscle strength following a one-year resistance training program in older adults. Experimental Gerontology, 139.

Eskilsson, T., Fjellman-Wiklund, A., Ek Malmer, E., Stigsdotter Neely, A., Malmberg Gavelin, H., Slunga Järvholm, L., Boraxbekk, C-J. & Nordin, M.(2020). Hopeful struggling for health: Experiences of participating in computerized cognitive training and aerobic training for persons with stress-related exhaustion disorder. Scandinavian Journal of Psychology.

Friedman, B. B., Suri, S., Solé-Padullés, C., Düzel, S., Drevon, C. A., Baaré, W. F. C., Bartrés-Faz, D., Fjell, A. M., Johansen-Berg, H., Madsen, K. S., Nyberg, L., Penninx, B. W. J. H., Sexton, C., Walhovd, K. B., Zsoldos, E. & Budin-Ljøsne, I. (2020). Are People Ready for Personalized Brain Health? Perspectives of Research Participants in the Lifebrain Consortium. The Gerontologist.

Hansen, A. L., Boraxbekk, C-J., Petersen, E. T., Paulson, O. B., Siebner, H. R. & Marsman, A. (2020). Regional glia-related metabolite levels are higher at older age and scale negatively with visuo-spatial working memory: A cross-sectional proton MR spectroscopy study at 7 tesla on normal cognitive ageing. Cold Spring Harbor Protocols. 36 p., 864496.

Karalija, N., Jonassson, L., Johansson, J., Papenberg, G., Salami, A., Andersson, M., Riklund, K., Nyberg, L. & Boraxbekk, C-J. (2020). High long-term test-retest reliability for extrastriatal 11C-raclopride binding in healthy older adults.
Journal of cerebral blood flow and metabolism.

Wheeler, M. J., Green, D. J., Ellis, K. A., Cerin, E., Heinonen, I., Naylor, L. H., Larsen, R., Wennberg, P., Boraxbekk, C-J., Lewis, J., Eikelis, N., Lautenschlager, N. T., Kingwell, B. A., Lambert, G., Owen, N. & Dunstan, D. W. (2020).
Distinct effects of acute exercise and breaks in sitting on working memory and executive function in older adults: a three-arm, randomised cross-over trial to evaluate the effects of exercise with and without breaks in sitting on cognition.
British Journal of Sports Medicine.

Bangsbo, J., Blackwell, J., Boraxbekk, C-J., Caserotti, P., Dela, F., Evans, A. B., Jespersen, A. P., Gliemann, L., Kramer, A. F., Lundbye-Jensen, J., Mortensen, E. L., Lassen, A. J., Gow, A. J., Harridge, S. D. R., Hellsten, Y., Kjaer, M., Kujala, U. M., Rhodes, R. E., Pike, E. C. J., Skinner, T., Skovgaard, T., Troelsen, J., Tulle, E., Tully, M. A., van Uffelen, J. G. Z. & Viña, J. (2019). Copenhagen Consensus statement 2019: physical activity and ageing. British Journal of Sports Medicine. 53, 14, p. 856-858.

Bojsen-Møller, E., Boraxbekk, C-J., Ekblom, Ö., Blom, V. & Ekblom, M. M. (2019). Relationships between Physical Activity, Sedentary Behaviour and Cognitive Functions in Office Workers.
International Journal of Environmental Research and Public Health. 16, 23, p. 1-15, 4721.

Düzel, E., Acosta-Cabronero, J., Berron, D., Biessels, G. J., Björkman-Burtscher, I., Bottlaender, M., Bowtell, R., Buchem, M. V., Cardenas-Blanco, A., Boumezbeur, F., Chan, D., Clare, S., Costagli, M., de Rochefort, L., Fillmer, A., Gowland, P., Hansson, O., Hendrikse, J., Kraff, O., Ladd, M. E., Ronen, I., Petersen, E., Rowe, J. B., Siebner, H., Stoecker, T., Straub, S., Tosetti, M., Uludag, K., Vignaud, A., Zwanenburg, J. & Speck, O. (2019). European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND). Alzheimer's & dementia (Amsterdam, Netherlands). 11, p. 538-549.

Hedlund, M., Lindelöf, N., Johansson, B., Boraxbekk, C-J. & Rosendahl, E. (2019). Development and Feasibility of a Regulated, Supramaximal High-Intensity Training Program Adapted for Older Individuals. Frontiers in physiology. 10, p. 1-12, 590.

Holm, S. K., Madsen, K. S., Vestergaard, M., Born, A. P., Paulson, O. B., Siebner, H. R., Uldall, P. & Baaré, W. F. C. (2019). Previous glucocorticoid treatment in childhood and adolescence is associated with long-term differences in subcortical grey matter volume and microstructure. NeuroImage. Clinical. 23, p. 1-11, 101825. 

Jonasson, L. S., Nyberg, L., Axelsson, J., Kramer, A. F., Riklund, K. & Boraxbekk, C-J. (2019). Higher striatal D2-receptor availability in aerobically fit older adults but non-selective intervention effects after aerobic versus resistance training. NeuroImage. 202, p. 1-10, 116044.

Magnusson, P. O., Boer, V. O., Marsman, A., Paulson, O. B., Hanson, L. G. & Petersen, E. T. (2019). Gamma-aminobutyric acid edited echo-planar spectroscopic imaging (EPSI) with MEGA-sLASER at 7T.
Magnetic Resonance in Medicine. 81, 2, p. 773-780.

Månsson, K. N. T., Lindqvist, D., Yang, L. L., Svanborg, C., Isung, J., Nilsonne, G., Bergman-Nordgren, L., El Alaoui, S., Hedman-Lagerlöf, E., Kraepelien, M., Högström, J., Andersson, G., Boraxbekk, C-J., Fischer, H., Lavebratt, C., Wolkowitz, O. M. & Furmark, T. (2019). Improvement in indices of cellular protection after psychological treatment for social anxiety disorder. Translational psychiatry. 9, p. 1-10, 340.

Marsman, A. & Pol, H. H. (2019). Glutamaterge neurotransmissie. Handboek schizofreniespectrumstoornissen. 2nd udg. De Tijdstroom/Boom, Bind 2019. p. 370-385..

Malmberg Gavelin, H., Eskilsson, T., Boraxbekk, C.J., Josefsson, M., Stigsdotter Neely, A., & Slunga Järvholm L. (2018). Rehabilitation for improved cognition in patients with stress-related exhaustion disorder: RECO – a randomized clinical trial. Stress.

Boraxbekk, C.-J. (2018). Non-invasive brain stimulation and neuro-enhancement in aging. Clinical Neurophysiology, 129, 464-65.

Baruël Johansen, L., Madsen, K. S., Andersen, K. W., Madsen, K. H., Siebner, H. R. & Baaré, W. F. C. (2017) Reduced orbitofrontal functional network centrality characterizes high neuroticism across childhood and adolescence.

Stomby, A., Otten, J., Ryberg, M., Nyberg, L., Olsson, T. & Boraxbekk, C-J. (2017). A Paleolithic Diet with and without Combined Aerobic and Resistance Exercise Increases Functional Brain Responses and Hippocampal Volume in Subjects with Type 2 Diabetes. Frontiers in Aging Neuroscience. 9, 391.

Jonasson, L. S., Axelsson, J., Riklund, K. & Boraxbekk, C.-J. (2017). Simulating effects of brain atrophy in longitudinal PET imaging with an anthropomorphic brain phantom.
Physics in Medicine and Biology. 62, 13, p. 5213-5227.

Gavelin, H. M., Neely, A. S., Andersson, M., Eskilsson, T., Järvholm, L. S. & Boraxbekk, C-J. (2017). Neural activation in stress-related exhaustion: Cross-sectional observations and interventional effects.
Psychiatry Research. 269, p. 17-25.

Flodin, P., Jonasson, L. S., Riklund, K., Nyberg, L. & Boraxbekk, C.-J. (2017). Does Aerobic Exercise Influence Intrinsic Brain Activity?: An Aerobic Exercise Intervention among Healthy Old Adults.Frontiers in Aging Neuroscience. 9, p. 267.

Eskilsson, T., Slunga Järvholm, L., Malmberg Gavelin, H., Stigsdotter Neely, A. & Boraxbekk, C-J. (2017). Aerobic training for improved memory in patients with stress-related exhaustion: a randomized controlled trial. BMC Psychiatry. 17, 322, p. 1-10, 322.

Bas-Hoogendam, J. M., van Steenbergen, H., Nienke Pannekoek, J., Fouche, J. P., Lochner, C., Hattingh, C. J., Cremers, H. R., Furmark, T., Månsson, K. N. T., Frick, A., Engman, J., Boraxbekk, C.-J., Carlbring, P., Andersson, G., Fredrikson, M., Straube, T., Peterburs, J., Klumpp, H., Phan, K. L., Roelofs, K., Veltman, D. J., van Tol, M. J., Stein, D. J. & van der Wee, N. J. A. (2017). Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder. NeuroImage: Clinical. 16, p. 678-688.

Jonasson, L.S., Nyberg, L., Kramer, A.F., Lundquist, A., Riklund, K., & Boraxbekk, C.-J. (2017). Aerobic exercise intervention, cognitive performance, and brain structure: Results from the physical influences on brain in aging (PHIBRA) study. Frontiers in Aging Neuroscience; 8, 336.

Boraxbekk, C.-J., Salami, A., Wåhlin, A., & Nyberg, L. (2016). Physical activity over a decade modifies age-related decline in perfusion, gray matter volume, and functional connectivity of the posterior default mode network - a multimodal approach. NeuroImage; 131, 133-141

News & Events

Group Members

Carl-Johan Boraxbekk

Group Leader

Anouk Marsman

Esben Thade Petersen

Naiara Demnitz

Sussi Larsen

Anna Plachti

Show all group members (9)

External Collaborators

Prof. Erik Lykke Mortensen

Department of Public Health, Copenhagen University


Prof. Michael Kjær

Department of Clinical Medicine, Bispebjerg Hospital, University of Copenhagen


Prof. Gunhild Waldemar

Department of Neurology, Copenhagen University Hospital Rigshospitalet 


Prof. Lars Nyberg

Umeå Center for  Functional Brain Imaging