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[EXPIRED] A postdoc in unpacking Bradykinesia (“slowness of movement”) in Parkinson’s Disease with MRI

Parkinson’s disease affects how people move, think, and feel. Yet, despite decades of research, one of its central motor symptoms, bradykinesia, is still not fully understood. Although often described simply as “slowness of movement,” bradykinesia actually covers several different types of motor difficulties. Some improve with dopaminergic treatment, others don’t, and we still lack a clear framework for how these components fit together. That’s the gap this project aims to close.

What is this project about?

If you enjoy tackling big questions with modern tools, join us on the Components of Bradykinesia (CoBra) project, funded by the Lundbeck Foundation. Our goal is to disentangle the different elements of bradykinesia by combining high‑resolution movement tracking (cameras, accelerometers, etc.) with structural and functional MRI. You’ll help identify hidden patterns in movement behavior and link them to underlying neural signatures.

We are seeking a motivated postdoctoral scientist to conduct cutting-edge research at the intersection of clinical neuroscience, advanced analysis methods and magnetic resonance imaging.

Who will you be joining? You will be working in the Movement Disorders group where researchers with different backgrounds and expertise combine theoretical and clinical knowledge with advanced assessment and analysis methods. You will be interacting with many different projects within the field of Movement Disorders and there is ample opportunity for close cooperation with DRCMR-researchers from a great variety of disciplines as well as clinicians. We act in concert, and make sure no-one is left alone with difficult tasks.

The Danish Research Centre for Magnetic Resonance (DRCMR) is one of the leading research centers for biomedical MRI in Europe (www.drcmr.dk). Our mission is to triangulate MR physics, basic physiology, and clinical research. Approximately 75 researchers from a diverse range of disciplines are currently pursuing basic and clinically applied MR, electrophysiology, and brain stimulation research with a focus on structural, functional, and metabolic MRI of the human brain and its disorders. The DRCMR is embedded in the Department for Radiology and Nuclear Medicine at Copenhagen University Hospital Hvidovre. In 2025, Copenhagen has again been rated as the most liveable city in the world (https://www.eiu.com/n/copenhagen-replaces-vienna-as-worlds-most-liveable-city/).

The position:

You will be employed as a postdoc for a two-year period at the Danish Research Centre for Magnetic Resonance with high possibilities of extension. You will join the Movement Disorders group led by senior researcher David Meder.

Your daily tasks will vary according to the flow of the projects, but will mainly be centered around:

  • Developing an assessment battery of bradykinetic symptoms based on existing theories and frameworks of bradykinesia.
  • Acquiring data in people with Parkinson’s disease and control participants
  • Use unsupervised data-driven as well as hypothesis-driven analysis methods to uncover the component structure of bradykinesia
  • Acquiring and analyzing structural and functional MRI data in people with Parkinson’s disease in an MRI-compatible sub-set of tasks
  • engaging in teaching, knowledge dissemination, and publication of results in international, recognized scientific journals

The ideal candidate

  • You hold a PhD degree in Neuroscience, Sports Sciences, Biomedical Engineering, Medicine or a related field.
  • You enjoy working in the lab: developing an experimental setup with technical equipment, piloting and assessing data
  • You have experience in conducting experiments with human subjects—preferably including patients.
  • As you will be interacting with patients, Danish language skills are an advantage, but not a prerequisite.
  • You have good programming skills (preferably in Matlab or Python).
  • Additional expertise in data-driven analysis methods (principal component analysis, clustering methods etc.) or Bayesian modeling is a major advantage.
  • You enjoy being part of a multidisciplinary and international research team and integrating technological innovations into your neuroscience research.
  • You have excellent written and interpersonal communication skills.

The project will be supervised by Senior Researcher David Meder in close collaboration with Prof. Hartwig Siebner.

Starting date: is expected to be in April 2026.

Salary and Terms of Employment

You will be employed as a postdoc for a period of 24 months with good possibilities of extension. Salary, pension and terms of employment are in accordance with the agreement between the Danish Regions (Danske Regioner) and the relevant professional organization. The salary depends on background education and seniority. Further, supplements can be negotiated. Note that candidates coming from abroad may be eligible for tax reductions. The position is open for candidates of all nationalities.

We see diversity as strength and encourage all persons regardless of gender, age, ethnicity, disabilities or religion to apply.

Applications should include a cover letter, CV and list of publications. References are also highly welcome. Applications must be submitted on-line through the RegionH job portal - click HERE.

Application deadline: 13th March 2026 at 23:59 (CET)

For further information regarding the position, please contact David Meder.
Direct line:  +45 3862 1184; Email:

 

Selected Publications

Recent publications & Pre-prints 

Naiara Demnitz, Oliver J. Hulme, Hartwig R. Siebner, Michael Kjaer, Klaus P. Ebmeier, Carl-Johan Boraxbekk, Claire M. Gillan (2023). Characterising the covariance pattern between lifestyle factors and structural brain measures: a multivariable replication study of two independent ageing cohorts, Neurobiology of Aging, Volume 131,2023, Pages 115-123, ISSN 0197-4580,IF 3.7.

TH Siebner, JD Hove, CF Madelung, OJ Hulme, F Bendtsen, HR Siebner, Flemming Bendtsen, Mads Barløse (2024). No difference in postprandial mesenteric blood flow between healthy younger and elderly individuals, Scientific Reports 14 (1), 8689.

TS Hjerresen, M Bentz, AB Nejad, E Raffin, KW Andersen, OJ Hulme, Hartwig Roman Siebner, Kerstin Jessica Plessen. Performing well but not appreciating it–A trait feature of anorexia nervosa. JCPP advances 4 (1), e12194.

Oliver Hulme, Arne Vanhoyweghen, Colm Connaughton, Ole Peters, Simon Steinkamp, Alexander Adamou, Dominik Baumann, Vincent Ginis, Bert Verbruggen, James Price, and Benjamin Skjold (2023). Reply to “The Limitations of Growth-Optimal Approaches to Decision Making Under Uncertainty”. Econ Journal Watch, 20(2) p335-348.

Hulme Oliver J., Roulston Barrie, Overgaard Morten (2023). Does report modality modulate psychophysical sensitivity? The jury remains out. Frontiers in Psychology, 14, https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1226588.

Thorup AAE,… Hulme OJ, … Nordentoft M (2022). The Danish High-Risk and Resilience Study-VIA 15 - A Study Protocol for the Third Clinical Assessment of a Cohort of 522 Children Born to Parents Diagnosed With Schizophrenia or Bipolar Disorder and Population-Based Controls. Frontiers in Psychiatry.

Lopez-Yepez JS, Martin J, Hulme OJ, Kvitsiani D. (2021). A normative account of choice history effects in mice and humans. PloS Computational Biology.

Lopez-Yepez JS, Martin J, Hulme OJ, Kvitsiani D. (2021)
A normative account of choice history effects in mice and humans
PLoS Computational Biology

Meder D, Rabe F, Morville T, Madsen KH, Koudahl MT, Dolan RJ, Siebner HR, Hulme OJ. (2021)
Ergodicity-breaking reveals time optimal economic behavior in humans
PLoS Computational Biology

Morville T, Friston KJ, Burdakov D, Siebner HR, Hulme OJ. (Pre-print)
The Homeostatic Logic of Reward
bioRxiv, doi.org/10.1101/242974.

Morville T, Madsen K, Siebner HR, Hulme OJ. (2021)
Reward signaling in brainstem nuclei under glycemic flux
PloS One

Hulme, OJ, Wagenmakers EJ, Damkier P, Madelung CF, Siebner HR, Helweg-Larsen J, Gronau Q, Benfield TL, Madsen KH. (2021) A Bayesian reanalysis of the effects of hydroxychloroquine and azithromycin on viral carriage in patients with COVID-19.
PloS One. doi.org/10.1371/journal.pone.0245048

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizau J, Hulme OJ, Billig AJ., Litvak V, Price CJ., Moran RJ., Costello A, Pillay D, Lambert C. (2020)
Effective immunity and second waves: a dynamic causal modelling study
Wellcome Open Res2020, 5:204 (doi.org/10.12688/wellcomeopenres.16253.2)

van der Vegt JPM, Hulme OJ, Madsen KH, Buhmann C, Bloem BR, Münchau A, Helmich RC, Siebner HR (2020)
Dopamine agonist treatment increases sensitivity to gamble outcomes in the hippocampus in de novo Parkinson’s disease
NeuroImage Clinical

Faranda D, Castillo IP, Hulme OJ, Jezequel A, Lamb J, Sato Y, Thompson E, (2020)                                                                         
Asymptotic estimates of SARS-CoV-2 infection counts and their sensitivity to stochastic perturbation
Chaos. 2020;30(5):051107. doi:10.1063/5.0008834

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizau J, Hulme OJ, Billig AJ, Litvak V, Price CJ, Moran RJ., Lambert C. (2020)
Second waves, social distancing, and the spread of COVID-19 across America.
Wellcome Open Res 2020, 5:103 (doi.org/10.12688/wellcomeopenres.15986.1)

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizau J, Hulme OJ, Billig AJ, Litvak V, Price CJ, Moran RJ, Lambert C. (2020)
Dynamic causal modelling of COVID-19.
Wellcome Open Res 2020, 5:89

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizau J, Hulme OJ, Billig AJ., Litvak V, Price CJ., Moran RJ., Costello A, Pillay D, Lambert C. (2020)
Testing and tracking in the UK: A dynamic causal modelling study
Wellcome Open Research 5 (144), 144  

Hulme OJ, Morville T, Gutkin B. (2019)
Neurocomputational Theories of Homeostatic Control
Physics of Life Reviews, Jul 19. pii: S1571-0645(19)30100-9. doi: 10.1016/j.plrev.2019.07.005  

Hulme OJ, Webb EJ, Sebald A. (2019)
An Introduction to Physiological Economics
Handbook of Research Methods and Applications in Experimental Economics, Edward Elgar Publishing. 

Hulme OJ, Kvitsiani D. (2019)
Extending Models of How Foraging Works: Uncertainty, Controllability, and Survivability
Behavioral and Brain Sciences 2019 Jan;42:e43. doi: 10.1017/S0140525X18002017

Hallsson BG, Siebner HR, Hulme OJ. (2018)
Fairness, fast and slow: A review of dual process models of fairness
Neuroscience and Biobehavioral Reviews. Jun;89:49-60. doi: 10.1016/j.neubiorev.2018.02.016.

Christensen BJ, Schmidt JB, Nielsen MS, Tækkerd L, Holm L, Lunn S, Brediee WLP, Ritz C, Holst JJ, Hansen T, Hilbert A, le Roux CW, Hulme OJ, Siebner HR, Morville T, Naver L, Floyd, AK, Sjödin A. (2018)
Patient profiling for success after weight loss surgery: An interdisciplinary study protocol
Contemporary Clinical Trials Communications. Feb 17;10:121-130. doi: 10.1016/j.conctc.2018.02.002.

Larsen KM, Mørup M,  Birknow MR, Fischer E, Hulme OJ,  Vangkilde A, Schmock H, Baaré WF, Didriksen M, Olsen L, Werge T, Siebner HR, Garrido MI. (2018)
Altered auditory processing and top-down connectivity in 22q11.2 Deletion Syndrome
Schizophrenia Research. Jan 30. pii: S0920-9964(18)30048-3. doi: 10.1016/j.schres.2018.01.026.

Meder D, Kolling N, Verhagen L, Wittmann MK, Scholl J, Madsen KH, Hulme OJ, Behrens TEJ, Rushworth MFS. (2017)
Simultaneous representation of a spectrum of dynamically changing value estimates during decision making
Nature Communications. Dec 5;8(1):1942. doi: 10.1038/s41467-017-02169-w.

Friis-Olivarius M, Hulme OJ, Skov M, Ramsøy TZ, Siebner HR. (2017)
Imaging the Creative Unconscious: Reflexive Neural Responses to Objects in the Visual and Parahippocampal Region Predicts State and Trait Creativity
Scientific Reports. Oct 31;7(1):14420. doi: 10.1038/s41598-017-14729-7.

Group Members

Oliver Hulme

Group Leader

Simon Steinkamp

Denise Monkau

External Collaborators

Prof. Derek Byrne


Dr. Ole Peters


Dr. Alex Adamou


Dr. Mark Kirstein


Dr. Yonatan Berman


Prof. Sten Madsbad


Assoc. Prof. Tobias Andersen


Assoc. Prof. Christoffer Clemmensen


Postdoc Claus Brandt


Prof. Duda Kvitsiani


Adam Goldstein