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[EXPIRED] The Capital Region of Copenhagen is looking for a PhD candidate in EEG and ultra-high field MRI within developmental neuropsychiatry

Are you interested in unravelling how alterations in developing brain function and structure contribute to developmental psychiatric disorders? Do you thrive working in inspiring multidisciplinary teams, bridging between brain mapping, computational modelling, and clinical neuroscience? Then you are the person we are looking for!

The Danish Research Centre for Magnetic Resonance (DRCMR) at Copenhagen University Hospital Hvidovre (Denmark) is seeking a 3-year PhD candidate in EEG and ultra-high field MRI within the field of developmental psychiatry. Together with our strong clinical collaborators at the Child and Adolescent Psychiatry Unit, we are currently running the prospective Danish High Risk and Resilience Study (VIA) (www.drcmr.dk/via). The VIA study longitudinally follows the largest register-based cohort of children (n=522) in the world born to parents with schizophrenia or bipolar disorder or none of these disorders. Children were assessed at the ages of 7, 11, and 15 years with neuroimaging included at age 11 and onwards. We are currently running the second longitudinal neuroimaging follow-up at age 19 years.

You will mainly be working on the longitudinal VIA data, with a focus on EEG data and 7T spectroscopy data. The project involves collection of both EEG and MRI data in the VIA cohort as well as analyses of EEG and MRI data, with a strong focus on the EEG part.

You will be a member of the “Developmental Psychiatry” group (www.drcmr.dk/developmental-psychiatry)  where the VIA project is embedded (www.drcmr.dk/via). You will thereby have ample possibilities to interact with researchers who are working on related multimodal neuroimaging studies.

The PhD candidate position involves a tight collaboration with Prof. Merete Nordentoft (Region Hovedstaden - Psychiatry and University of Copenhagen) as the main PI of the VIA cohort study and the VIA neuroimaging group, including neuroimagers at DRCMR and the Center of Integrative Neuroscience (CFIN), Aarhus, Denmark.

Qualifications:

  • Master's degree in neuroscience, computational science and engineering, psychology or equivalent.
  • Experience with EEG and/or MRI data acquisition and/or data analyses.
  • Experience in Matlab or Python programming is highly desired.
  • Experience with signal processing and data analyses is desired.
  • You have a good team spirit, innovative and constructive thinking and are excited about research.
  • You have an interest and/or experience in mechanisms/pathophysiology related to child- and adolescent mental health and developmental neuropsychiatry.
  • You enjoy being part of a multidisciplinary and international research team and integrating technological innovations into your neuroscience research.
  • You possess good English communication skills.

The project will be carried out at the DRCMR, which is a leading research centre for biomedical MRI in Europe (www.drcmr.dk) focusing on the brain. Approx. 75 researchers from more than 20 countries and a diverse range of disciplines are currently pursuing basic and clinically applied MR research and its validation with a focus on structural, functional, and metabolic MRI of the human brain and its disorders. The DRCMR is embedded in the Department of Radiology and Nuclear Medicine, a large diagnostic imaging department including all biomedical imaging modalities at the Copenhagen University Hospital Hvidovre.

The DRCMR has a state-of-the-art research infrastructure for preclinical and human medical imaging, which includes six whole-body MR scanners (one 7T, four 3T and one 1.5T scanners), a preclinical 7T scanner, a High-Performance Computer cluster and several state-of-the-art laboratories for electrophysiology and non-invasive brain stimulation.

The postdoc project will be supervised by Senior Researcher Melissa Larsen and Professor Hartwig Siebner.

Salary and Terms of Employment:

You will be employed as a PhD candidate for a period of 3 years. Salary, pension and terms of employment are in accordance with the agreement between the Danish Regions (Danske Regioner) and the relevant professional organization. The salary depends on background education and seniority. Note that candidates coming from abroad may be eligible for tax reductions. The position is open for candidates of all nationalities.

We see diversity as strength and encourage all persons regardless of gender, age, ethnicity, disabilities, or religion to apply.

 

Selected Publications

Recent publications & Pre-prints 

Naiara Demnitz, Oliver J. Hulme, Hartwig R. Siebner, Michael Kjaer, Klaus P. Ebmeier, Carl-Johan Boraxbekk, Claire M. Gillan (2023). Characterising the covariance pattern between lifestyle factors and structural brain measures: a multivariable replication study of two independent ageing cohorts, Neurobiology of Aging, Volume 131,2023, Pages 115-123, ISSN 0197-4580,IF 3.7.

TH Siebner, JD Hove, CF Madelung, OJ Hulme, F Bendtsen, HR Siebner, Flemming Bendtsen, Mads Barløse (2024). No difference in postprandial mesenteric blood flow between healthy younger and elderly individuals, Scientific Reports 14 (1), 8689.

TS Hjerresen, M Bentz, AB Nejad, E Raffin, KW Andersen, OJ Hulme, Hartwig Roman Siebner, Kerstin Jessica Plessen. Performing well but not appreciating it–A trait feature of anorexia nervosa. JCPP advances 4 (1), e12194.

Oliver Hulme, Arne Vanhoyweghen, Colm Connaughton, Ole Peters, Simon Steinkamp, Alexander Adamou, Dominik Baumann, Vincent Ginis, Bert Verbruggen, James Price, and Benjamin Skjold (2023). Reply to “The Limitations of Growth-Optimal Approaches to Decision Making Under Uncertainty”. Econ Journal Watch, 20(2) p335-348.

Hulme Oliver J., Roulston Barrie, Overgaard Morten (2023). Does report modality modulate psychophysical sensitivity? The jury remains out. Frontiers in Psychology, 14, https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1226588.

Thorup AAE,… Hulme OJ, … Nordentoft M (2022). The Danish High-Risk and Resilience Study-VIA 15 - A Study Protocol for the Third Clinical Assessment of a Cohort of 522 Children Born to Parents Diagnosed With Schizophrenia or Bipolar Disorder and Population-Based Controls. Frontiers in Psychiatry.

Lopez-Yepez JS, Martin J, Hulme OJ, Kvitsiani D. (2021). A normative account of choice history effects in mice and humans. PloS Computational Biology.

Lopez-Yepez JS, Martin J, Hulme OJ, Kvitsiani D. (2021)
A normative account of choice history effects in mice and humans
PLoS Computational Biology

Meder D, Rabe F, Morville T, Madsen KH, Koudahl MT, Dolan RJ, Siebner HR, Hulme OJ. (2021)
Ergodicity-breaking reveals time optimal economic behavior in humans
PLoS Computational Biology

Morville T, Friston KJ, Burdakov D, Siebner HR, Hulme OJ. (Pre-print)
The Homeostatic Logic of Reward
bioRxiv, doi.org/10.1101/242974.

Morville T, Madsen K, Siebner HR, Hulme OJ. (2021)
Reward signaling in brainstem nuclei under glycemic flux
PloS One

Hulme, OJ, Wagenmakers EJ, Damkier P, Madelung CF, Siebner HR, Helweg-Larsen J, Gronau Q, Benfield TL, Madsen KH. (2021) A Bayesian reanalysis of the effects of hydroxychloroquine and azithromycin on viral carriage in patients with COVID-19.
PloS One. doi.org/10.1371/journal.pone.0245048

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizau J, Hulme OJ, Billig AJ., Litvak V, Price CJ., Moran RJ., Costello A, Pillay D, Lambert C. (2020)
Effective immunity and second waves: a dynamic causal modelling study
Wellcome Open Res2020, 5:204 (doi.org/10.12688/wellcomeopenres.16253.2)

van der Vegt JPM, Hulme OJ, Madsen KH, Buhmann C, Bloem BR, Münchau A, Helmich RC, Siebner HR (2020)
Dopamine agonist treatment increases sensitivity to gamble outcomes in the hippocampus in de novo Parkinson’s disease
NeuroImage Clinical

Faranda D, Castillo IP, Hulme OJ, Jezequel A, Lamb J, Sato Y, Thompson E, (2020)                                                                         
Asymptotic estimates of SARS-CoV-2 infection counts and their sensitivity to stochastic perturbation
Chaos. 2020;30(5):051107. doi:10.1063/5.0008834

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizau J, Hulme OJ, Billig AJ, Litvak V, Price CJ, Moran RJ., Lambert C. (2020)
Second waves, social distancing, and the spread of COVID-19 across America.
Wellcome Open Res 2020, 5:103 (doi.org/10.12688/wellcomeopenres.15986.1)

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizau J, Hulme OJ, Billig AJ, Litvak V, Price CJ, Moran RJ, Lambert C. (2020)
Dynamic causal modelling of COVID-19.
Wellcome Open Res 2020, 5:89

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizau J, Hulme OJ, Billig AJ., Litvak V, Price CJ., Moran RJ., Costello A, Pillay D, Lambert C. (2020)
Testing and tracking in the UK: A dynamic causal modelling study
Wellcome Open Research 5 (144), 144  

Hulme OJ, Morville T, Gutkin B. (2019)
Neurocomputational Theories of Homeostatic Control
Physics of Life Reviews, Jul 19. pii: S1571-0645(19)30100-9. doi: 10.1016/j.plrev.2019.07.005  

Hulme OJ, Webb EJ, Sebald A. (2019)
An Introduction to Physiological Economics
Handbook of Research Methods and Applications in Experimental Economics, Edward Elgar Publishing. 

Hulme OJ, Kvitsiani D. (2019)
Extending Models of How Foraging Works: Uncertainty, Controllability, and Survivability
Behavioral and Brain Sciences 2019 Jan;42:e43. doi: 10.1017/S0140525X18002017

Hallsson BG, Siebner HR, Hulme OJ. (2018)
Fairness, fast and slow: A review of dual process models of fairness
Neuroscience and Biobehavioral Reviews. Jun;89:49-60. doi: 10.1016/j.neubiorev.2018.02.016.

Christensen BJ, Schmidt JB, Nielsen MS, Tækkerd L, Holm L, Lunn S, Brediee WLP, Ritz C, Holst JJ, Hansen T, Hilbert A, le Roux CW, Hulme OJ, Siebner HR, Morville T, Naver L, Floyd, AK, Sjödin A. (2018)
Patient profiling for success after weight loss surgery: An interdisciplinary study protocol
Contemporary Clinical Trials Communications. Feb 17;10:121-130. doi: 10.1016/j.conctc.2018.02.002.

Larsen KM, Mørup M,  Birknow MR, Fischer E, Hulme OJ,  Vangkilde A, Schmock H, Baaré WF, Didriksen M, Olsen L, Werge T, Siebner HR, Garrido MI. (2018)
Altered auditory processing and top-down connectivity in 22q11.2 Deletion Syndrome
Schizophrenia Research. Jan 30. pii: S0920-9964(18)30048-3. doi: 10.1016/j.schres.2018.01.026.

Meder D, Kolling N, Verhagen L, Wittmann MK, Scholl J, Madsen KH, Hulme OJ, Behrens TEJ, Rushworth MFS. (2017)
Simultaneous representation of a spectrum of dynamically changing value estimates during decision making
Nature Communications. Dec 5;8(1):1942. doi: 10.1038/s41467-017-02169-w.

Friis-Olivarius M, Hulme OJ, Skov M, Ramsøy TZ, Siebner HR. (2017)
Imaging the Creative Unconscious: Reflexive Neural Responses to Objects in the Visual and Parahippocampal Region Predicts State and Trait Creativity
Scientific Reports. Oct 31;7(1):14420. doi: 10.1038/s41598-017-14729-7.

Group Members

Oliver Hulme

Group Leader

Simon Steinkamp

Maria Elisabeth Catharina van der Weij

External Collaborators

Prof. Derek Byrne


Dr. Ole Peters


Dr. Alex Adamou


Dr. Mark Kirstein


Dr. Yonatan Berman


Prof. Sten Madsbad


Assoc. Prof. Tobias Andersen


Assoc. Prof. Christoffer Clemmensen


Postdoc Claus Brandt


Prof. Duda Kvitsiani


Adam Goldstein