Overall research areas
Understanding and characterization of disease progression
Cell metabolism using hyperpolarized 13-carbon (see Hyperpolarization Research Group )
Brain maturation
Brain tissue microstructure (see Diffusion group)
Aquaporins and hydrocephalus

Lise Vejby Søgaard
Research group leader
DRCMR

Disease progression
Cell metabolism using HP13C
Rapid metabolic imaging of HP13C

Tim Dyrby
DRCMR

Brain tissue microstructure
Brain maturation

Peter Magnusson
DRCMR

Cell metabolism using HP13C
Rapid metabolic imaging of HP13C

Henrik Lundell
DRCMR

Spinal cord imaging
Diffusion MRI acquisition

Mette Hauge Lauritzen
DRCMR

Cardiac metabolism using HP13C

Christoffer Laustsen
DRCMR/Aarhus University

Metabolism in diabetic kidneys
Acquisition techniques for HP13C

Sascha Gude
DRCMR

Laboratory

Anders Skjolding
Copenhagen University/DRCMR

Aquaporins and hydrocephalus

Objectives:
The preclinical research group aim for better understanding and characterization of disease progression. Models of common major diseases are used for longitudinal investigations, including effects of treatment.
Focus areas are in vivo studies of cell metabolism using hyperpolarized 13C enriched substances in mammary cancer and ischemic heart disease, and ex vivo studies of brain tissue microstructure and connectivity using diffusion imaging. In addition, the possible correlation between aquaporin expression and periventricular diffusion in hydrocephalus is investigated.

Resources:
The group uses a 4.7 T pre-clinical Varian MR-scanner with newly installed strong gradients for the studies. A range of RF coils are available including special coils for 13C and other special nuclei. For preparation the group has a well equipped laboratory and MR compatible physiological monitoring equipment is available.

Selected publications:

Butt SA, Søgaard LV, Magnusson P, Lauritzen M, Laustsen C, Åkeson P, Ardenkjær-Larsen JH. Imaging cerebral 2-ketoisocaproate metabolism with hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging. Journal of Cerebral Blood Flow&Metabolism 2012 32(8):1508-14

Skjolding AD, Rowland IJ, Søgaard LV, Praetorius J, Penkowa M, Juhler M. Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 expression in the rat brain. Cerebrospinal Fluid Research 2010 7(1):20.

Madsen KS, Holm DA, Søgaard LV, Rowland IJ. Effect of paramagnetic manganese cations on (1)H MRS of the brain. NMR Biomed. 2008 Nov;21(10):1087-93.

Brandt CT, Simonsen H, Liptrot M, Søgaard LV, Lundgren JD, Østergaard C, Frimodt-Møller N, Rowland IJ. In vivo study of experimental pneumococcal meningitis using magnetic resonance imaging. BMC Medical Imaging 2008, 8:1. doi:10.1186/1471-2342-8-1

Dyrby TB, Søgaard LV, Parker GJ, Alexander DC, Lind NM, Baaré WF, Hay-Schmidt A, Eriksen N, Pakkenberg B, Paulson OB, Jelsing J. Validation of in vitro probabilistic tractography. NEUROIMAGE 37(4):1267-77 OCT 2007

Collaborators:
Bartholin Institute, Copenhagen Biocenter
Department of Neurosurgery, Copenhagen University Hospital Rigshospitalet
Department of Pathology, Copenhagen University Hospital Hvidovre