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[EXPIRED] The Capital Region of Copenhagen is looking for a PhD candidate in EEG and ultra-high field MRI within developmental neuropsychiatry

Are you interested in unravelling how alterations in developing brain function and structure contribute to developmental psychiatric disorders? Do you thrive working in inspiring multidisciplinary teams, bridging between brain mapping, computational modelling, and clinical neuroscience? Then you are the person we are looking for!

The Danish Research Centre for Magnetic Resonance (DRCMR) at Copenhagen University Hospital Hvidovre (Denmark) is seeking a 3-year PhD candidate in EEG and ultra-high field MRI within the field of developmental psychiatry. Together with our strong clinical collaborators at the Child and Adolescent Psychiatry Unit, we are currently running the prospective Danish High Risk and Resilience Study (VIA) (www.drcmr.dk/via). The VIA study longitudinally follows the largest register-based cohort of children (n=522) in the world born to parents with schizophrenia or bipolar disorder or none of these disorders. Children were assessed at the ages of 7, 11, and 15 years with neuroimaging included at age 11 and onwards. We are currently running the second longitudinal neuroimaging follow-up at age 19 years.

You will mainly be working on the longitudinal VIA data, with a focus on EEG data and 7T spectroscopy data. The project involves collection of both EEG and MRI data in the VIA cohort as well as analyses of EEG and MRI data, with a strong focus on the EEG part.

You will be a member of the “Developmental Psychiatry” group (www.drcmr.dk/developmental-psychiatry)  where the VIA project is embedded (www.drcmr.dk/via). You will thereby have ample possibilities to interact with researchers who are working on related multimodal neuroimaging studies.

The PhD candidate position involves a tight collaboration with Prof. Merete Nordentoft (Region Hovedstaden - Psychiatry and University of Copenhagen) as the main PI of the VIA cohort study and the VIA neuroimaging group, including neuroimagers at DRCMR and the Center of Integrative Neuroscience (CFIN), Aarhus, Denmark.

Qualifications:

  • Master's degree in neuroscience, computational science and engineering, psychology or equivalent.
  • Experience with EEG and/or MRI data acquisition and/or data analyses.
  • Experience in Matlab or Python programming is highly desired.
  • Experience with signal processing and data analyses is desired.
  • You have a good team spirit, innovative and constructive thinking and are excited about research.
  • You have an interest and/or experience in mechanisms/pathophysiology related to child- and adolescent mental health and developmental neuropsychiatry.
  • You enjoy being part of a multidisciplinary and international research team and integrating technological innovations into your neuroscience research.
  • You possess good English communication skills.

The project will be carried out at the DRCMR, which is a leading research centre for biomedical MRI in Europe (www.drcmr.dk) focusing on the brain. Approx. 75 researchers from more than 20 countries and a diverse range of disciplines are currently pursuing basic and clinically applied MR research and its validation with a focus on structural, functional, and metabolic MRI of the human brain and its disorders. The DRCMR is embedded in the Department of Radiology and Nuclear Medicine, a large diagnostic imaging department including all biomedical imaging modalities at the Copenhagen University Hospital Hvidovre.

The DRCMR has a state-of-the-art research infrastructure for preclinical and human medical imaging, which includes six whole-body MR scanners (one 7T, four 3T and one 1.5T scanners), a preclinical 7T scanner, a High-Performance Computer cluster and several state-of-the-art laboratories for electrophysiology and non-invasive brain stimulation.

The postdoc project will be supervised by Senior Researcher Melissa Larsen and Professor Hartwig Siebner.

Salary and Terms of Employment:

You will be employed as a PhD candidate for a period of 3 years. Salary, pension and terms of employment are in accordance with the agreement between the Danish Regions (Danske Regioner) and the relevant professional organization. The salary depends on background education and seniority. Note that candidates coming from abroad may be eligible for tax reductions. The position is open for candidates of all nationalities.

We see diversity as strength and encourage all persons regardless of gender, age, ethnicity, disabilities, or religion to apply.

 

Selected Publications

Atudorei M, del Agua Villa C, Gether U, Cenci MA, Siebner HR and Rickhag M (2025) Bilateral chemogenetic activation of Intratelencephalic Neurons in Motor Cortex Reduces Spontaneous Locomotor Activity in Mice. Neurobiology of Disease. 2024 Nov 26:106755. doi: 10.1016/j.nbd.2024.106755)

Del Agua Villa C, Atudorei M, Siebner HR and Rickhag M (2024) Pharmacological Targeting of Dopamine D1 or D2 Receptors Evokes a Rapid-Onset, Distinct Parkinsonian Motor Phenotype in Mice. European Journal of Neuroscience. 2024 Dec 3. doi: 10.1111/ejn.16622)

Apuschkin M, Støier JF, Skov L, Ejdrup A, Chan Andersen R, Dmytriyeva O,  Sørensen AT, Egerod K, Holst B,  Rickhag M,  Schwartz T and Gether U (2024) An atlas of GPCRs in dopamine neurons: identification of the free fatty acid receptor-4 (FFAR4) as a regulator of food and water intake. (2024 Jul 23;43(7):114509. doi: 10.1016 - Cell Reports)

Herborg F, Konrad L, Pugh C, Delignat-Lavaud B, Friis Rather C, , Awadallah N, Pino Reyes J, Berlin F, Rickhag M, Torres G, Holst B, Trudeau LE and Gether U (2023) Mouse model of atypical DAT deficiency syndrome uncovers dopamine dysfunction associated with parkinsonism and psychiatric disease. bioRxiv, 2023.08. 17.553695

Sørensen G, Rickhag M, Leo D, Lycas MD, Ridderstrøm PH, Weikop P, Lilja JH, Rifes P, Herborg F, Woldbye D, Wörtwein G, Gainetdinov RR, Fink-Jensen A, Gether U, Disruption of the PDZ-domain binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis and reward motivation, Journal of Biological Chemistry (2021), doi: https:// doi.org/10.1016/j.jbc.2021.101361.

Herborg F, Jensen K, Tolstoy S, Arends N, Posselt L, Shekar A, Aguilar J, Lund V, Erreger K, Rickhag M, Lycas M, Lonsdale M, Rahbek-Clemmensen T, Sørensen A, Newman A, Løkkegaard A, Kjærulff O, Hansen T, Møller L, Matthies H, Galli A, Hjermind L, Gether U (2021) Dominant-negative actions of a dopamine transporter variant identified in patients with parkinsonism and neuropsychiatric disease. Journal of Clinical Investigation Insight 2021 Aug 10:151496

Christensen M, Nørr SE, Gether U and Rickhag M (2021). Direct-Pathway Spiny Projection Neuron Inhibition Evokes Transient Circuit Imbalance Manifested as Rotational Behavior.  Neuroscience. 2021 Jan 15;453:32-42

Ciriachi C, Svane-Petersen D and Rickhag M (2019). Genetic Tools to Study Complexity of Striatal Function. Journal of Neuroscience Research. 2019 Oct;97(10):1181-1193

DiCarlo GE, Aguilar JI, Matthies HJ, Harrison FE, Bundschuh KE, West A, Hashemi P, Herborg F, Rickhag M, Chen H, Gether U, Wallace MT, Galli A (2019). Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors. Journal of Clinical Investigation. 2019 May 16;129(8):3407-3419.

Bay Kønig A, Ciriachi C, Gether U and Rickhag M (2019). Chemogenetic Targeting of Dorsomedial Direct-Pathway Striatal Projection Neurons Selectively Elicits Rotational Behavior in Mice. Neuroscience. 2019 Mar 1; 401:106-116

Runegaard A, Sørensen AT, Fitzpatrick C, Jørgensen S, Petersen A, Hansen N, Weikop P, Andreasen J, Mikkelsen J, Perrier JF, Woldbye D, Rickhag M, Wörtwein G and Gether U (2018). Locomotor- and reward-enhancing effects of cocaine are differentially regulated by chemogenetic stimulation of Gi-signaling in dopaminergic neurons. eNeuro: 0345-17.2018 

Jensen K, Sørensen G, Dencker D, Owens W, Rahbek-Clemmensen T, Brett Lever M, Runegaard A, Riis Christensen N, Weikop P, Wörtwein G, Fink-Jensen A, Madsen K, Daws L, Gether U and Rickhag M (2018). PICK1-deficient mice exhibit impaired response to cocaine and dysregulated dopamine homeostasis. eNeuro:0422-17.2018

Jensen KL, Runegaard AH, Weikop P, Gether U and Rickhag M (2017). Assessment of Dopaminergic Homeostasis in Mice by Use of High-Performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake. Journal of Visualized Experiments, 127, e56093, doi:10.3791/56093

Runegaard AH, Jensen KL, Fitzpatrick CM, Dencker D, Weikop P, Gether U and Rickhag M (2017). Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice. European Journal of Neuroscience, 45(1):121-128

Apuschkin M, Stilling S, Rahbek-Clemmensen T, Sørensen G, Fortin G, Herborg Hansen F, Eriksen J, Trudeau LE, Egerod K, Gether U and Rickhag M (2015). A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity. European Journal of Neuroscience 42: 2438-2454

Steinkellner T, Montgomery TR, Hofmaier T, Kudlacek O, Yang JW, Rickhag M, Jung G, Lubec G, Gether U, Freissmuth M, Sitte HH (2015). Amphetamine action at the cocaine- and antidepressant sensitive serotonin transporter is modulated by αCaMKII. Journal of Neuroscience 27;35(21):8258-71

Steinkellner T, Mus L, Eisenrauch B, Constantinescu A, Leo D, Konrad L, Rickhag M, Sørensen G, Efimova EV, Kong E, Willeit M, Sotnikova TD, Kudlacek O, Gether U, Freissmuth M, Pollak DD, Gainetdinov RR, Sitte HH (2014). In vivo amphetamine action is contingent on alpha-CaMKII. Neuropsychopharmacology 39(11): 2681-93

Rickhag M, Owens WA, Winkler MT, Strandfelt KN, Rathje M, Andresen B, Sørensen G, Madsen KL, Jørgensen TN, Wörtwein G, Woldbye DP, Sitte H, Daws LC and Gether U (2013).  Membrane permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release. Journal of Biological Chemistry 20;288(38): 27534-44

Rickhag M, Hansen FH, Sørensen G, Strandfelt KN, Andresen B, Gotfryd K, Madsen KL, Vestergaard-Klewe I, Ammendrup-Johnsen I, Eriksen J, Newman AH, Füchtbauer EM, Gomeza J, Woldbye DP, Wörtwein G and Gether U (2013). A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter. Nature Communications 4:1580

Holst B, Madsen KL, Jansen AM, Jin C, Rickhag M, Lund VK, Jensen M, Bhatia V, Sørensen G, Madsen AN, Xue Z, Møller SK, Woldbye DP, Qvortrup K, Huganir R, Stamou D, Kjærulff O and Gether U. (2013). PICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose Tolerance. PLoS Biology 11(4):e1001542

Ruscher K, Shamloo M, Rickhag M, Ladunga I, Soriano L, Gisselsson L, Toresson H, Ruslim-Litrus L, Oksenberg D, Urfer R, Johansson BB, Nikolich K and Wieloch T  (2011). The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke. Brain 134(3): 732-46

Ruscher K, Johannesson E, Brugiere E, Erickson A, Rickhag M and Wieloch T (2009). Enriched enviroment reduces apolipoprotein E (ApoE) in reactive astrocytes and attenuates inflammation of the peri-infarct tissue after experimental stroke. Journal of Cerebral Blood Flow and Metabolism 29(11): 1796-805

Ruscher K, Johannesson E, Rickhag M and Wieloch T (2009). Spatio-temporal changes of apolipoprotein E (ApoE) in the rat brain after experimental stroke. Enriched housing condition attenuates ApoE expression. Journal of Cerebral Blood Flow and Metabolism 29, S267-S267

Rickhag M, Deierborg T, Patel S, Ruscher K and Wieloch T (2008). Apolipoprotein D is elevated in oligodendrocytes in the peri-infarct region after experimental stroke – Influence of enriched environment. Journal of Cerebral Blood Flow and Metabolism 28(3): 551-62;

Rickhag M, Teilum M and Wieloch T (2007). Rapid and long-term induction of effector immediate-early genes (BDNF, Neuritin and Arc) in peri-infarct cortex and dentate gyrus after ischemic injury in rat brain. Brain Research. 1151: 203-210

Shamloo M, Soriano L, von Schack D, Rickhag M, Chin DJ, Gonzalez-Zulueta M, Gido G, Urfer R, Wieloch T and Nikolich K (2006). Npas4, a novel helix-loop-helix PAS domain protein, is regulated in response to cerebral ischemia. European Journal of Neuroscience. 24(10): 2705-2720

Takao K, Rickhag M, Hegardt C, Oredsson S and Persson L (2006). Induction of apoptotic cell death by putrescine. Int J Biochem Cell Biol. 38(4): 621-8

Rickhag M, Wieloch T, Gidö G, Elmer E, Krogh M, Murray J, Lohr S, Bitter H, Chin DJ, von Schack D, Shamloo M and Nikolich K (2006). Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia-induced gene expression patterns, and reveals a biphasic activation of genes in surviving tissue. Journal of Neurochemistry. 96(1): 14-29 

Urfer R, Rickhag M, Oksenberg D, Shamloo M, Lohr S, Murray J, Krogh M, Johansson B, Nikolich K, Wieloch T (2005). A new approach to enhancement of functional recovery after stroke by genomics analysis of the enriched environment model. Stroke. 36(2): 427-428

Group Members

Mattias Rickhag

Group Leader

Hartwig R. Siebner

Mihai Atudorei

Show all group members (4)

External Collaborators

Professor Angela Cenci Nilsson
Lund University, Sweden


Professor Ulrik Gether
University of Copenhagen, Denmark


Professor Gilad Silberberg
Karolinska Institutet, Sweden