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[EXPIRED] A postdoc in unpacking Bradykinesia (“slowness of movement”) in Parkinson’s Disease with MRI

Parkinson’s disease affects how people move, think, and feel. Yet, despite decades of research, one of its central motor symptoms, bradykinesia, is still not fully understood. Although often described simply as “slowness of movement,” bradykinesia actually covers several different types of motor difficulties. Some improve with dopaminergic treatment, others don’t, and we still lack a clear framework for how these components fit together. That’s the gap this project aims to close.

What is this project about?

If you enjoy tackling big questions with modern tools, join us on the Components of Bradykinesia (CoBra) project, funded by the Lundbeck Foundation. Our goal is to disentangle the different elements of bradykinesia by combining high‑resolution movement tracking (cameras, accelerometers, etc.) with structural and functional MRI. You’ll help identify hidden patterns in movement behavior and link them to underlying neural signatures.

We are seeking a motivated postdoctoral scientist to conduct cutting-edge research at the intersection of clinical neuroscience, advanced analysis methods and magnetic resonance imaging.

Who will you be joining? You will be working in the Movement Disorders group where researchers with different backgrounds and expertise combine theoretical and clinical knowledge with advanced assessment and analysis methods. You will be interacting with many different projects within the field of Movement Disorders and there is ample opportunity for close cooperation with DRCMR-researchers from a great variety of disciplines as well as clinicians. We act in concert, and make sure no-one is left alone with difficult tasks.

The Danish Research Centre for Magnetic Resonance (DRCMR) is one of the leading research centers for biomedical MRI in Europe (www.drcmr.dk). Our mission is to triangulate MR physics, basic physiology, and clinical research. Approximately 75 researchers from a diverse range of disciplines are currently pursuing basic and clinically applied MR, electrophysiology, and brain stimulation research with a focus on structural, functional, and metabolic MRI of the human brain and its disorders. The DRCMR is embedded in the Department for Radiology and Nuclear Medicine at Copenhagen University Hospital Hvidovre. In 2025, Copenhagen has again been rated as the most liveable city in the world (https://www.eiu.com/n/copenhagen-replaces-vienna-as-worlds-most-liveable-city/).

The position:

You will be employed as a postdoc for a two-year period at the Danish Research Centre for Magnetic Resonance with high possibilities of extension. You will join the Movement Disorders group led by senior researcher David Meder.

Your daily tasks will vary according to the flow of the projects, but will mainly be centered around:

  • Developing an assessment battery of bradykinetic symptoms based on existing theories and frameworks of bradykinesia.
  • Acquiring data in people with Parkinson’s disease and control participants
  • Use unsupervised data-driven as well as hypothesis-driven analysis methods to uncover the component structure of bradykinesia
  • Acquiring and analyzing structural and functional MRI data in people with Parkinson’s disease in an MRI-compatible sub-set of tasks
  • engaging in teaching, knowledge dissemination, and publication of results in international, recognized scientific journals

The ideal candidate

  • You hold a PhD degree in Neuroscience, Sports Sciences, Biomedical Engineering, Medicine or a related field.
  • You enjoy working in the lab: developing an experimental setup with technical equipment, piloting and assessing data
  • You have experience in conducting experiments with human subjects—preferably including patients.
  • As you will be interacting with patients, Danish language skills are an advantage, but not a prerequisite.
  • You have good programming skills (preferably in Matlab or Python).
  • Additional expertise in data-driven analysis methods (principal component analysis, clustering methods etc.) or Bayesian modeling is a major advantage.
  • You enjoy being part of a multidisciplinary and international research team and integrating technological innovations into your neuroscience research.
  • You have excellent written and interpersonal communication skills.

The project will be supervised by Senior Researcher David Meder in close collaboration with Prof. Hartwig Siebner.

Starting date: is expected to be in April 2026.

Salary and Terms of Employment

You will be employed as a postdoc for a period of 24 months with good possibilities of extension. Salary, pension and terms of employment are in accordance with the agreement between the Danish Regions (Danske Regioner) and the relevant professional organization. The salary depends on background education and seniority. Further, supplements can be negotiated. Note that candidates coming from abroad may be eligible for tax reductions. The position is open for candidates of all nationalities.

We see diversity as strength and encourage all persons regardless of gender, age, ethnicity, disabilities or religion to apply.

Applications should include a cover letter, CV and list of publications. References are also highly welcome. Applications must be submitted on-line through the RegionH job portal - click HERE.

Application deadline: 13th March 2026 at 23:59 (CET)

For further information regarding the position, please contact David Meder.
Direct line:  +45 3862 1184; Email:

 

Recent Publications

Beha GH, Stemmerik MG, Boer VO, van der Ploeg AT, van der Beek NAME, Andersen H, Marsman A, Jacobsen LN, Theunissen MTM, Petersen ET, Vissing J. 2025. Quantification of muscle glycogen distribution in Pompe disease using 7 Tesla 13C NMR spectroscopy. JNNP. Accepted.

Güler S, Zivkovic I, Boer VO, Zhurbenko V, Petersen ET. 2025. The mode of operation of high-impedance coils and shielded coaxial cable coils: A comparative study. NMR Biomed. 38(8): e70071. https://doi.org/10.1002/nbm.70071

London A, Schaufuss A, Povazan M, Dichman M-L, Merhout J, Dirksen C, Madsbad S, Siebner HR, Lundsgaard A, Fritzen AM, Kiens B, Bojsen-Møller KN. 2025. Effects of acute iso- and hypocaloric carbohydrate restriction on liver fat and glucose and lipid metabolism. J Clin Endocrinol Metab. dgaf382, https://doi.org/10.1210/clinem/dgaf382

Güler S, Povazan M, Zhurbenko V, Zivkovic I. 2025. An 8Tx/32Rx head-neck coil at 7T by combining 2Tx/32Rx Noval coil with 6TRx shielded coaxial cable elements. Magn Reson Med. 93(2): 864-872. https://doi.org/10.1002/mrm.30297

Madelung CF, Løkkegaard A, Fuglsang SA, Marques MM, Boer VO, Madsen KH, Hejl A-M, Meder D, Siebner HR. 2025. High-resolution mapping of substantia nigra in Parkinson’s disease using 7 tesla magnetic resonance imaging. Npj Parkinsons Dis. 11(113). https://doi.org/10.1038/s41531-025-00972-7

London A, Richter MM, Sjøberg KA, Wewer Albrechtsen NJ, Povazan M, Drici L, Schaufuss A, Madsen L, Øyen J, Madsbad S, Juul Holst J, van Hall G, Siebner HR, Richter EA, Kiens B, Lundsgaard A, Bojsen-Møller KN. 2024. The impact of short-term eucaloric low- and high-carbohydrate diets on liver triacylglycersol content in males with overweight and obesity: a randomized crossover study. Am J Clin Nutrition. 120(2): 283-293. https://doi.org/10.1016/j.ajcnut.2024.06.006

Madsen MAJ, Povazan M, Wiggermann V, Lundell H, Blinkenberg M, Romme Christensen J, Sellebjerg F, Siebner HR. 2024. Association of cortical lesions with regional glutamate, GABA, N-Acetylaspartate, and Myoinositol levels in patients with multiple sclerosis. Neurology. 103(1): e209543. https://doi.org/10.1212/WNL.0000000000209543

Stærkind H, Jensen K, Müller JH, Boer VO, Polzik ES, Petersen ET. 2024. High-field optical cesium magnetometer for magnetic resonance imaging. PRX Quantum. 5(2): 020320. https://doi.org/10.1103/PRXQuantum.5.020320

Stærkind H, Jensen K, Müller JH, Boer VO, Petersen ET, Polzik ES. 2023. Precision measurement of the excited state Landé g-factor and diamagnetic shift of the Cesium D2 line. Phys Rev X. 13(2): 021036. https://doi.org/10.1103/PhysRevX.13.021036

Boer VO, Pedersen JO, Arango N, Kuang I, Stockmann J, Petersen ET. 2022. Improving brain B0 shimming using an easy and accessible multi-coil shim array at ultra-high field. MAGMA. 35(6): 943-951. https://doi.org/10.1007/s10334-022-01014-6

Andersen M, Laustsen M, Boer V. Accuracy investigations for volumetric head-motion navigators with and without EPI at 7 T. 2022. Magn Reson Med. 88(3): 1198-1211. https://doi.org/10.1002/mrm.29296

Madsen MAJ, Wiggermann V, Marques MFM, Lundell H, Cerri S, Puonti O, Blinkenberg M, Romme Christensen J, Sellebjerg F, Siebner HR. 2022. Linking lesions in sensorimotor cortex to contralateral hand function in multiple sclerosis: a 7 T MRI study. Brain. 145(10): 3522-3535. https://doi.org/10.1093/brain/awac203

Sandström KO, Baltzersen OB, Marsman A, Lemvigh CK, Boer VO, Bojesen KB, Nielsen MØ, Lundell H, Sulaiman DK, Sørensen ME, Fagerlund B, Lahti AC, Syeda WT, Pantelis C, Petersen ET, Glenthøj BY, Siebner HR, Ebdrup BH. 2022. Add-on memantine to dopamine antagonism to improve negative symptoms at first psychosis – the AMEND trial protocol. Front Psychiatry. 13: 889572. https://doi.org/10.3389/fpsyt.2022.889572

Madelung CF, Meder D, Fuglsang SA, Marques MM, Boer VO, Madsen KH, Petersen ET, Hejl A-M, Løkkegaard A, Siebner HR. 2022. Locus coeruleus shows a spatial pattern of structural disintegration in Parkinson’s disease. Movement Disord. 37(3): 479-489. https://doi.org/10.1002/mds.28945

 

Selected Recent Conference Abstracts

Engel K, Wiggermann V, Ronen I, Lundell H. Correction of phase fluctuations in diffusion-weighted MRS at high b-values with external phantom reference. ISMRM annual meeting. 05/2025,

Madsen MAJ, Christiansen L, Povazan M, Wiggermann V, Siebner HR. Regional glutamate but not GABA concentration scales with TMS-based measures of cortical excitability – a combined 7T MR spectroscopy and TMS study of the human primary motor hand area. Brain Stimulation, Kyoto, Japan, 02/2025 [Brain Stimulation 18(1) 576, 2025]

Madsen MAJ, Wiggermann V, Lundell H, Christiansen L, Romme Christensen J, Blinkenberg M, Sellebjerg F, Siebner HR. The impact of pathway-specific cortical and white matter pathology on trans-callosal conduction and inhibition in multiple sclerosis, ECTRIMS, Copemhagen, Denmark, 09/2024

Madsen MAJ, Wiggermann V, Christiansen L, Povazan M, Lundell H, Puonti O, Romme Christensen J, Sellebjerg F, Siebner HR. The ipsilateral silent period and its link to cortical lesions in multiple sclerosis, Brain Stimulation, Lisbon, Portugal, 02/2023, [Brain Stimulation 14(6) 1628, 2023]

Stemmerik M, Beha G, Boer V, Marsman A, Jacobsen L, Petersen E, Vissing J. 2022. Using high-field magnetic resonance spectroscopy to measure muscle glycogen in patients with McArdle disease. Neuromuscular Disorders. 32. S73-S74.

Beha G, Stemmerik M, Boer V, Marsman A, Jacobsen L, Petersen E, Vissing J. 2022. Quantification of glycogen distribution in late-onset Pompe patients using 7 Tesla C13 NMR spectroscopy. Neuromuscular Disorders. 32. S73.

Madsen MAJ, Wiggermann V, Povazan M, Lundell H, Boer VO, Marsman A, Blinkenberg MB, Romme Christensen J, Sellebjerg FT, Siebner HR. 2022. Linking cortical demyelination to changes in brain metabolism in multiple sclerosis: a 7T MR spectroscopy study. ECTRIMS annual (virtual) meeting.

Güler S, Costa G, Boer V, Paulides M, Baltus P, Petersen E, Zivkovic I. 2022. Shielded coaxial cable coils: the array configuration for maximized central SNR at 7T MRI. Joint Annual Meeting ISMRM-ESMRMB, 31st annual ISMRM meeting.

Güler S, Zhurbenko V, Zivkovic I, Boer V, Petersen ET. 2022. Second resonance mode ensure intrinsic low coupling between elements on shielded-coaxial-cable coil designs. Joint Annual Meeting ISMRM-ESMRMB, 31st annual ISMRM meeting.

Group Members

Vanessa Wiggermann

Group Leader

Henrik Lundell

Group Leader

Lars G. Hanson

Jesús Díaz Pereira

Beatriz Neto de Jesus

Sara Godfrey

Show all group members (23)

External Collaborators

Jeroen Hendrikse

Department of Radiology, University Medical Center Utrecht, The Netherlands


Dennis Klomp

Department of Radiology, University Medical Center Utrecht, The Netherlands


Andrew Webb

Department of Radiology, Leiden University Medical Center, The Netherlands


Matthias van Osch

Department of Radiology, Leiden University Medical Center, The Netherlands


Itamar Ronen

Department of Radiology, Leiden University Medical Center, The Netherlands


Karin Markenroth Bloch

Swedish National 7T facility, Lund, Sweden


Gunther Helms

Swedish National 7T MRI Facility, Medical Radiation Physics, Lund, Sweden


Kirsten Borup Bojesen

Center for Neuropsychiatric Schizophrenia Research, Mental Health Services, Capital Region of Denmark, Denmark