Bigger axons conduct signals faster. That’s neuroscience 101.

But axons don’t have one diameter — they have a distribution. So when we measure conduction delays, which axons are we actually capturing?

In our new paper, we ask a simple but uncomfortable question: Does the measurement method shape the structure–function relationship we infer?

By comparing optogenetic stimulation, MRI, electron microscopy, and electrophysiology, we show that these methodologies all capture different portions of the axon diameter distribution.

A reminder that how we measure the brain matters for what we conclude about it.

Read the paper:
https://lnkd.in/e3tSKNS5

This is the result of great teamwork with Christian Stald Skoven, Mariam Andersson, Miren Lur Barquin Torre, Marco Pizzolato and Hartwig Siebner.