Precision Neuromodulation & Therapy

A range of non-invasive transcranial brain stimulation (NTBS) techniques are available to evoke brain activity or to modulate the brain´s ongoing activity.

neurophys2   neurophys3


The ability of NTBS to shape brain function has enormous scientific and therapeutic potential. However, the underlying mechanisms of NTBS are still poorly understood. The Precision Neuromodulation and Therapy Group has two main goals: (i) to advance NTBS as interventional tool to modify brain activity, and (ii) to use NTBS to uncover and optimize causal interactions in functional brain networks.  

The Precision Neuromodulation and Therapy group studies the effects of NTBS in the human brain, both the local effects of NTBS on the stimulated brain region and remote effects in interconnected brain regions. The group has published several landmark papers showing that NTBS can trigger a homeostatic plasticity-like effect in the human motor cortex. We have also shown that NTBS can produce lasting effects on sensorimotor processing and action selection by changing effective connectivity in sensorimotor networks.

  • To better understand how NTBS acts on the brain, we capture the neurophysiological effects of NTBS using electrophysiological (MEP, EEG) and advanced brain mapping techniques (MRI, MRS) and relate these changes to NTBS effects at the behavioral level. We use computational modelling at the behavioral and neurophysiological level to test our research hypotheses about how NTBS changes the functional integration in the targeted brain networks.
  • To enhance the efficacy and reliability of NTBS, we develop new, biologically informed stimulation protocols.  Here we draw inspiration from the natural activity patterns (motifs) which are generated by the brain itself. 
  • To closely interact with the brain´s ongoing activity, we monitor the ongoing expression of functional brain states with neurophysiological methods. We use this information to inform the timing and pattern of NTBS in open-loop and closed-loop NTBS set-ups. 

 
The Precision Neuromodulation and Therapy group is headed by Prof. Hartwig Siebner and is a main contributor to the ongoing PRECISION-BCT project funded by Innovation and led by Hartwig Siebner. We closely collaborate with the “Neurophysics” research group, the “Control of Movement (CoMo)” research group, and the “Computational Neuroimaging” group.

Key projects

  1. Linear shape-based mapping of the primary motor hand area (M1-HAND) to study representational plasticity of intrinsic hand muscles in human M1-HAND 
  2. Targeting the phase of intrinsic brain oscillations with EEG-guided TMS
  3. Optimizing patterned NTBS of the human motor cortex

neurophys1 1  

Selected Publications

Siebner HR. Does TMS of the precentral motor hand knob primarily stimulate the dorsal premotor cortex or the primary motor hand area?  Brain Stimul 2020. Published online.

Madsen KH, Karabanov AN , Krohne LG , Safeldt MG , Tomasevic L , Siebner HR. No Trace of Phase: Corticomotor Excitability Is Not Tuned by Phase of Pericentral Mu-Rhythm. Brain Stimul. 2019,12:1261-1270.

Karabanov AN, Saturnino GB, Thielscher A, Siebner HR. Can Transcranial Electrical Stimulation Localize Brain Function? Front Psychol. 2019,10:213.

Raffin E, Siebner HR. Human Primary Motor Hand Area: Synergistic Interplay Between Training and Immobilization. Cereb. Cortex 2019,29:356-371.
Conde V, Tomasevic L, Akopian I, Stanek K, Saturnino GB, Thielscher A, Bergmann TO*, Siebner HR.* The non-transcranial TMS-evoked potential is an inherent source of ambiguity in TMS-EEG Studies. Neuroimage 2019,185:300-312. * shared last authors

Dubbioso R, Raffin E, Karabanov A, Thielscher A, Siebner HR. Centre-surround organization of fast sensorimotor integration in human motor hand area. Neuroimage 2017,158:37-47. 

Bergmann TO, Karabanov A, Hartwigsen G, Thielscher A, Siebner HR. Combining non-invasive transcranial brain stimulation with neuroimaging and electrophysiology: Current approaches and future perspectives.  Neuroimage. 2016,140:4-19.

Raffin E*, Pellegrino G*, Di Lazzaro V, Thielscher A, Siebner HR. Bringing transcranial mapping into shape: Sulcus-aligned mapping captures motor somatotopy in human primary motor hand area. NeuroImage 2015, 120:164–175. * Shared first authors.

Group Members

Hartwig R. Siebner

Group Leader

Lasse Christiansen

Leo Tomasevic

Angela Mastropasqua

Marie Louise Liu

Show all group members (8)

External Collaborators

 

Institut for Idræt og Ernæring, KU

Lektor Anke Karabanov