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[EXPIRED] The Capital Region of Copenhagen is looking for a 2-years Research Assistant in transcranial stimulation-based brain circuit therapy

Are you eager to contribute to new forms of treatments for depression using personalized transcranial magnetic stimulation? Do you wish to pursue cutting-edge research at the intersection of clinical neuroscience and non-invasive brain stimulation? Then you should join us at DRCMR as we scale up our efforts to develop novel treatments for Major depressive disorder (MDD) based on brain mapping (magnetic resonance imaging [MRI] and electroencephalography [EEG]) and state-of-the-art personalized transcranial magnetic stimulation (TMS).

The position:

You will be employed as research assistant for 2 years at the Danish Research Centre for Magnetic Resonance (DRCMR). The employment period may lay the foundation for an extension into a PhD position. You will join the Brain network modulation group (https://www.drcmr.dk/brain-network-modulation) led by Prof. Hartwig Siebner and contributing to Precision brain circuit therapy (Precision-BCT) project (https://www.drcmr.dk/precision-bct), a multidisciplinary project involving Region H (Hvidovre Hospital and CNDR Psychiatric Center Glostrup), DTU Health Technology, and industrial partners.

Your role:

As our new research assistant, you will primarily be involved in carrying out an interventional study with TMS and neuro-navigated circuit stimulation, but also in other brain imaging experiments. You will have the opportunity to collaborate with an interdisciplinary team consisting of M.D.’s, psychologists, physiologists, engineers, and basic- and clinical neuroscientists.

Your daily tasks will vary according to the flow of the project, but will mainly center around:

  • Contributing to practical experimental routine, including subject recruitment, data collection, and analysis.
  • Conducting interventional brain stimulation studies in healthy volunteers and patients with MDD, involving the combination of EEG and TMS.
  • Assisting in acquiring and analyzing behavioral, and brain mapping data (e.g., EEG, fMRI) for assessing TMS efficacy.
  • Assisting in activities related to other Precision-BCT groups.
  • Engaging in teaching, knowledge dissemination, and publication of results in international, recognized scientific journals.                                                                         

Qualification Requirements

  • You hold a master’s degree in Neuroscience, Medicine, Biomedical engineering, Psychology, or related fields.
  • You enjoy being part of a multidisciplinary and international research team and integrating technological innovations into your neuroscience research.
  • You enjoy active involvement in the experimental procedures in the lab.
  • You possess strong interpersonal communication skills.
  • Experience in any of the following areas is advantageous:
    • Working with brain stimulation modalities and its integration with brain mapping methods (e.g., TMS/EEG)
    • Programming skills (preferably in Matlab or Python).
    • Processing and analyzing EEG/functional MRI data.
    • Conducting experiments with human subjects—preferably including patients.

The project will be led by Prof. Hartwig Siebner with this position under the daily supervision of Postdoc Armita Faghani.

About us:

The Danish Research Centre for Magnetic Resonance (DRCMR) is one of the leading research centers for biomedical MRI in Europe (www.drcmr.dk). Our mission is to triangulate MR physics, basic physiology, and clinical research. Approximately 75 researchers from a diverse range of disciplines are currently pursuing basic and clinical research using MR, electrophysiology, and brain stimulation to improve our understanding of the human brain and its disorders. The DRCMR is embedded in the Department of Radiology and Nuclear Medicine, a large diagnostic imaging department including all biomedical imaging modalities at Copenhagen University Hospital Hvidovre.

Selected Publications

Dunås T, Wåhlin A, Nyberg L, Boraxbekk C-J. 2021. Multimodal Image Analysis of Apparent Brain Age Identifies Physical Fitness as Predictor of Brain Maintenance. Cerebral Cortex. 31(7):3393-3407. https://doi.org/10.1093/cercor/bhab019

Hansen AL, Boraxbekk C-J, Petersen ET, Paulson OB, Andersen O, Siebner HR, Marsman A. 2021. Do glia provide the link between low-grade systemic inflammation and normal cognitive ageing? A 1H magnetic resonance spectroscopy study at 7 tesla. Journal of Neurochemistry. 159(1):185-196.

Nyberg L, Magnussen F, Lundquist A, Baaré W, Bartrés-Faz D, Bertram L, Boraxbekk CJ, Brandmaier AM, Drevon CA, Ebmeier K, Ghisletta P, Henson RN, Junqué C, Kievit R, Kleemeyer M, Knights E, Kühn S, Lindenberger U, Penninx BWJH, Pudas S, Sørensen Ø, Vaqué-Alcázar L, Walhovd KB, Fjell AM. 2021. Educational attainment does not influence brain aging. Proceedings of the National Academy of Sciences of the United States of America. 118(18):1-3. https://doi.org/10.1073/pnas.2101644118

Sandberg P, Boraxbekk C-J, Zogaj I, Nyberg L. 2021. Ancient Mnemonic in New Format-Episodic Memory Training With the Method of Loci in a Smart Phone Application. Journals of Gerontology - Series B Psychological Sciences and Social Sciences. 76(4):681-691. https://doi.org/10.1093/geronb/gbaa216

Vidal-Pineiro D, Wang Y, Krogsrud SK, Amlien IK, Baaré WF, Bartres-Faz D, Bertram L, Brandmaier AM, Drevon CA, Düzel S, Ebmeier K, Henson RN, Junqué C, Kievit RA, Kühn S, Leonardsen E, Lindenberger U, Madsen KS, Magnussen F, Mowinckel AM, Nyberg L, Roe JM, Segura B, Smith SM, Sørensen Ø, Suri S, Westerhausen R, Zalesky A, Zsoldos E, Walhovd KB, Fjell A. 2021. Individual variations in 'brain age' relate to early-life factors more than to longitudinal brain change. eLife. 10:1-19. https://doi.org/10.7554/eLife.69995

Lind, A., Boraxbekk, C.J., Petersen, E.T., Paulsson, O., Siebner, H., & Marsman, A. (2020). Regional myo-inositol, creatine and choline levels are higher at older age and scale negatively with visuo-spatial working memory: A cross-sectional proton MR spectroscopy study at 7 tesla on normal cognitive ageing. Journal of Neuroscience, 40(42), 8149-8159.

Nyberg, L., Boraxbekk, C.J., Eriksson Sörman, D., Hansson, P., Herlitz, A., Kauppi, K., Ljungberg, J.K., Lövheim, H., Lundquist, A., Nordin Adolfsson, A., Oudin, A., Pudas, S., Rönnlund, M., Stiernstedt, M., Sundström, A., & Adolfsson, R. (2020). Biological and environmental predictors of heterogeneity in neurocognitive ageing: Evidence from Betula and other longitudinal studies. Ageing Research Reviews.

Gylling AT, Bloch-Ibenfeldt M, Eriksen CS, Ziegler AK, Wimmelmann CL, Baekgaard M, Boraxbekk CJ, Siebner HR, Mortensen EL, & Kjaer M. (2020). Maintenance of muscle strength following a one-year resistance training program in older adults. Experimental Gerontology, 139.

Eskilsson, T., Fjellman-Wiklund, A., Ek Malmer, E., Stigsdotter Neely, A., Malmberg Gavelin, H., Slunga Järvholm, L., Boraxbekk, C-J. & Nordin, M.(2020). Hopeful struggling for health: Experiences of participating in computerized cognitive training and aerobic training for persons with stress-related exhaustion disorder. Scandinavian Journal of Psychology.

Friedman, B. B., Suri, S., Solé-Padullés, C., Düzel, S., Drevon, C. A., Baaré, W. F. C., Bartrés-Faz, D., Fjell, A. M., Johansen-Berg, H., Madsen, K. S., Nyberg, L., Penninx, B. W. J. H., Sexton, C., Walhovd, K. B., Zsoldos, E. & Budin-Ljøsne, I. (2020). Are People Ready for Personalized Brain Health? Perspectives of Research Participants in the Lifebrain Consortium. The Gerontologist.

Hansen, A. L., Boraxbekk, C-J., Petersen, E. T., Paulson, O. B., Siebner, H. R. & Marsman, A. (2020). Regional glia-related metabolite levels are higher at older age and scale negatively with visuo-spatial working memory: A cross-sectional proton MR spectroscopy study at 7 tesla on normal cognitive ageing. Cold Spring Harbor Protocols. 36 p., 864496.

Karalija, N., Jonassson, L., Johansson, J., Papenberg, G., Salami, A., Andersson, M., Riklund, K., Nyberg, L. & Boraxbekk, C-J. (2020). High long-term test-retest reliability for extrastriatal 11C-raclopride binding in healthy older adults.
Journal of cerebral blood flow and metabolism.

Wheeler, M. J., Green, D. J., Ellis, K. A., Cerin, E., Heinonen, I., Naylor, L. H., Larsen, R., Wennberg, P., Boraxbekk, C-J., Lewis, J., Eikelis, N., Lautenschlager, N. T., Kingwell, B. A., Lambert, G., Owen, N. & Dunstan, D. W. (2020).
Distinct effects of acute exercise and breaks in sitting on working memory and executive function in older adults: a three-arm, randomised cross-over trial to evaluate the effects of exercise with and without breaks in sitting on cognition.
British Journal of Sports Medicine.

Bangsbo, J., Blackwell, J., Boraxbekk, C-J., Caserotti, P., Dela, F., Evans, A. B., Jespersen, A. P., Gliemann, L., Kramer, A. F., Lundbye-Jensen, J., Mortensen, E. L., Lassen, A. J., Gow, A. J., Harridge, S. D. R., Hellsten, Y., Kjaer, M., Kujala, U. M., Rhodes, R. E., Pike, E. C. J., Skinner, T., Skovgaard, T., Troelsen, J., Tulle, E., Tully, M. A., van Uffelen, J. G. Z. & Viña, J. (2019). Copenhagen Consensus statement 2019: physical activity and ageing. British Journal of Sports Medicine. 53, 14, p. 856-858.

Bojsen-Møller, E., Boraxbekk, C-J., Ekblom, Ö., Blom, V. & Ekblom, M. M. (2019). Relationships between Physical Activity, Sedentary Behaviour and Cognitive Functions in Office Workers.
International Journal of Environmental Research and Public Health. 16, 23, p. 1-15, 4721.

Düzel, E., Acosta-Cabronero, J., Berron, D., Biessels, G. J., Björkman-Burtscher, I., Bottlaender, M., Bowtell, R., Buchem, M. V., Cardenas-Blanco, A., Boumezbeur, F., Chan, D., Clare, S., Costagli, M., de Rochefort, L., Fillmer, A., Gowland, P., Hansson, O., Hendrikse, J., Kraff, O., Ladd, M. E., Ronen, I., Petersen, E., Rowe, J. B., Siebner, H., Stoecker, T., Straub, S., Tosetti, M., Uludag, K., Vignaud, A., Zwanenburg, J. & Speck, O. (2019). European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND). Alzheimer's & dementia (Amsterdam, Netherlands). 11, p. 538-549.

Hedlund, M., Lindelöf, N., Johansson, B., Boraxbekk, C-J. & Rosendahl, E. (2019). Development and Feasibility of a Regulated, Supramaximal High-Intensity Training Program Adapted for Older Individuals. Frontiers in physiology. 10, p. 1-12, 590.

Holm, S. K., Madsen, K. S., Vestergaard, M., Born, A. P., Paulson, O. B., Siebner, H. R., Uldall, P. & Baaré, W. F. C. (2019). Previous glucocorticoid treatment in childhood and adolescence is associated with long-term differences in subcortical grey matter volume and microstructure. NeuroImage. Clinical. 23, p. 1-11, 101825. 

Jonasson, L. S., Nyberg, L., Axelsson, J., Kramer, A. F., Riklund, K. & Boraxbekk, C-J. (2019). Higher striatal D2-receptor availability in aerobically fit older adults but non-selective intervention effects after aerobic versus resistance training. NeuroImage. 202, p. 1-10, 116044.

Magnusson, P. O., Boer, V. O., Marsman, A., Paulson, O. B., Hanson, L. G. & Petersen, E. T. (2019). Gamma-aminobutyric acid edited echo-planar spectroscopic imaging (EPSI) with MEGA-sLASER at 7T.
Magnetic Resonance in Medicine. 81, 2, p. 773-780.

Månsson, K. N. T., Lindqvist, D., Yang, L. L., Svanborg, C., Isung, J., Nilsonne, G., Bergman-Nordgren, L., El Alaoui, S., Hedman-Lagerlöf, E., Kraepelien, M., Högström, J., Andersson, G., Boraxbekk, C-J., Fischer, H., Lavebratt, C., Wolkowitz, O. M. & Furmark, T. (2019). Improvement in indices of cellular protection after psychological treatment for social anxiety disorder. Translational psychiatry. 9, p. 1-10, 340.

Marsman, A. & Pol, H. H. (2019). Glutamaterge neurotransmissie. Handboek schizofreniespectrumstoornissen. 2nd udg. De Tijdstroom/Boom, Bind 2019. p. 370-385..

Malmberg Gavelin, H., Eskilsson, T., Boraxbekk, C.J., Josefsson, M., Stigsdotter Neely, A., & Slunga Järvholm L. (2018). Rehabilitation for improved cognition in patients with stress-related exhaustion disorder: RECO – a randomized clinical trial. Stress.

Boraxbekk, C.-J. (2018). Non-invasive brain stimulation and neuro-enhancement in aging. Clinical Neurophysiology, 129, 464-65.

Baruël Johansen, L., Madsen, K. S., Andersen, K. W., Madsen, K. H., Siebner, H. R. & Baaré, W. F. C. (2017) Reduced orbitofrontal functional network centrality characterizes high neuroticism across childhood and adolescence.

Stomby, A., Otten, J., Ryberg, M., Nyberg, L., Olsson, T. & Boraxbekk, C-J. (2017). A Paleolithic Diet with and without Combined Aerobic and Resistance Exercise Increases Functional Brain Responses and Hippocampal Volume in Subjects with Type 2 Diabetes. Frontiers in Aging Neuroscience. 9, 391.

Jonasson, L. S., Axelsson, J., Riklund, K. & Boraxbekk, C.-J. (2017). Simulating effects of brain atrophy in longitudinal PET imaging with an anthropomorphic brain phantom.
Physics in Medicine and Biology. 62, 13, p. 5213-5227.

Gavelin, H. M., Neely, A. S., Andersson, M., Eskilsson, T., Järvholm, L. S. & Boraxbekk, C-J. (2017). Neural activation in stress-related exhaustion: Cross-sectional observations and interventional effects.
Psychiatry Research. 269, p. 17-25.

Flodin, P., Jonasson, L. S., Riklund, K., Nyberg, L. & Boraxbekk, C.-J. (2017). Does Aerobic Exercise Influence Intrinsic Brain Activity?: An Aerobic Exercise Intervention among Healthy Old Adults.Frontiers in Aging Neuroscience. 9, p. 267.

Eskilsson, T., Slunga Järvholm, L., Malmberg Gavelin, H., Stigsdotter Neely, A. & Boraxbekk, C-J. (2017). Aerobic training for improved memory in patients with stress-related exhaustion: a randomized controlled trial. BMC Psychiatry. 17, 322, p. 1-10, 322.

Bas-Hoogendam, J. M., van Steenbergen, H., Nienke Pannekoek, J., Fouche, J. P., Lochner, C., Hattingh, C. J., Cremers, H. R., Furmark, T., Månsson, K. N. T., Frick, A., Engman, J., Boraxbekk, C.-J., Carlbring, P., Andersson, G., Fredrikson, M., Straube, T., Peterburs, J., Klumpp, H., Phan, K. L., Roelofs, K., Veltman, D. J., van Tol, M. J., Stein, D. J. & van der Wee, N. J. A. (2017). Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder. NeuroImage: Clinical. 16, p. 678-688.

Jonasson, L.S., Nyberg, L., Kramer, A.F., Lundquist, A., Riklund, K., & Boraxbekk, C.-J. (2017). Aerobic exercise intervention, cognitive performance, and brain structure: Results from the physical influences on brain in aging (PHIBRA) study. Frontiers in Aging Neuroscience; 8, 336.

Boraxbekk, C.-J., Salami, A., Wåhlin, A., & Nyberg, L. (2016). Physical activity over a decade modifies age-related decline in perfusion, gray matter volume, and functional connectivity of the posterior default mode network - a multimodal approach. NeuroImage; 131, 133-141

Group Members

Naiara Demnitz

Group Leader

Sussi Larsen

External Collaborators

Prof. Erik Lykke Mortensen

Department of Public Health, Copenhagen University

Prof. Michael Kjær

Department of Clinical Medicine, Bispebjerg Hospital, University of Copenhagen

Prof. Gunhild Waldemar

Department of Neurology, Copenhagen University Hospital Rigshospitalet 

Prof. Lars Nyberg

Umeå Center for  Functional Brain Imaging