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Christopher Madelung has done it again...
and shown the powerful insights to be gained from using…
Latest News
MD Joyce P. M. van der Vegt has together with colleagues and collaborators at the DRCMR, in Holland, and in Germany reported remarkable brain responses in patients with Parkinson's disease during a gambling task. In this study of newly diagnosed and untreated patients, attenuated brain activation compared to normal volunteers, was measured with functional MRI during reward processing. This effect likely influences the behavior of patients, and their well-known tendency to develop gambling addictions.
The scientific paper is published in the high-impact journal Brain, February 2013. It was conducted in the context of the ContAct research project.
A popular account of the study is available in Danish.
Full reference and link to the published article:
Attenuated neural response to gamble outcomes in drug-naive patients with Parkinson's disease
Joyce P. M. van der Vegt; Oliver J. Hulme; Simone Zittel; Kristoffer H. Madsen; Michael M. Weiss; Carsten Buhmann; Bastiaan R. Bloem; Alexander Munchau; Hartwig R. Siebner
Brain 2013; doi: 10.1093/brain/awt027. PDF
The cover page of the February issue of Journal of Magnetic Resonance features work performed at the preclinical MR scanner at DRCMR. The accompanying paper "Dynamic nuclear polarization and optimal control spatial-selective 13C MRI and MRS" describes the study in which Mads Sloth Vinding (Aarhus University) and Christoffer Laustsen (DRCMR and Aarhus University) used optimal control theory to design 2D spatially selective RF pulses. The method uses cleverly designed RF pulses that are applied together with modulated gradient waveforms to excite the magnetization only within a certain spatial area. As the front page image illustrates it was possible with this method to excite the letters "dnp" in a phantom containing hyperpolarized pyruvate. The method may provide means to establish highly sensitive and highly volume specific experiments for 13C metabolomic profiling in arbitrary detailed spatial regions.
Link to the JMR cover page
Link to the paper
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