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Oliver Hulme




Senior Researcher

Research Interests

I have broad interests in the physical, social, and biological sciences. My main interest is in the brain’s reward system. Put simply: how does it work, and why? I explore mathematical and computational theories that constrain how it should work, and then test the predictions of these theories against behavioral and neuroimaging data. There are two strands to this agenda. The first asks, how do reward computations help shape behaviour to regulate the physiological systems of the body. The second strand draws on physics. I am interested in the constraints that ergodicity imposes on decision-making, and whether such considerations can also offer a unified explanatory account of a number of disparate decision-making phenomena.

Curriculum Vitae



PhD in Neuroimaging, University College London


Special Student, Harvard University


MA in Physiological Sciences, Oxford University


2020 - Present

Honorary Fellow, Max-Planck UCL Centre for Computational Psychiatry & Aging

2019 - Present

External Fellow, London Mathematical Laboratory, UK

2015 - Present

Senior Researcher, Computational Neuroscience of Reward, DRCMR

2011 - 2015

Postdoctoral Researcher, DRCMR

2010 - 2011

Sessional Lecturer, University of British Columbia

2009 - 2009

Visiting Scholar, Welsh Institute of Cognitive Neuroscience

2007 - 2008

Postdoctoral Fellow in Cognitive Neuroscience, UCL

Full CV


H-index: 14  Researchgate score: 29.55  Citations (Google scholar): 1083 
Total peer-reviewed publications & pre-prints: 37 
First author publications & pre-prints: 10
Corresponding authorships: 14
Orcid number: 0000-0003-3139-4324. Full list of publications available at https://scholar.google.dk/citations?user=fhkJIuIAAAAJ&hl=en

Hulme, OJ, Wagenmakers EJ, Damkier P, Madelung CF, Siebner HR, Helweg-Larsen J, Gronau Q, Benfield TL, Madsen KH. (2021) A Bayesian reanalysis of the effects of hydroxychloroquine and azithromycin on viral carriage in patients with COVID-19. PloS One. doi.org/10.1371/journal.pone.0245048

Lopez-Yepez JS, Martin J, Hulme OJ, Kvitsiani D. (Pre-print) A normative account of choice history effects in mice and humans.  bioRxiv 2020.07.22.216234; doi: https://doi.org/10.1101/2020.07.22.216234

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizau J, Hulme OJ, Billig AJ., Litvak V, Price CJ., Moran RJ., Costello A, Pillay D, Lambert C. (Pre-print)
Effective immunity and second waves: a dynamic causal modelling study

Meder D, Rabe F, Morville T, Madsen KH, Koudahl MT, Dolan RJ, Siebner HR, Hulme OJ. (Pre-print) Ergodicity-breaking reveals time optimal economic behavior in humans

Morville T, Friston KJ, Burdakov D, Siebner HR, Hulme OJ. (Pre-print) The Homeostatic Logic of Reward. bioRxiv, doi.org/10.1101/242974. 

Morville T, Madsen K, Siebner HR, Hulme OJ. (Pre-print) Reward signaling in brainstem nuclei under glycemic flux. bioRxiv, doi.org/10.1101/243006.

van der Vegt JPM, Hulme OJ, Madsen KH, Buhmann C, Bloem BR, Münchau A, Helmich RC, Siebner HR (2020). Dopamine agonist treatment increases sensitivity to gamble outcomes in the hippocampus in de novo Parkinson’s disease. NeuroImage Clinical. IF 3.9 

Faranda D, Castillo IP, Hulme OJ, Jezequel A, Lamb J, Sato Y, Thompson E, (2020) Asymptotic estimates of SARS-CoV-2 infection counts and their sensitivity to stochastic perturbation
Chaos. 2020;30(5):051107. doi:10.1063/5.0008834. IF 2.6

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizau J, Hulme OJ, Billig AJ, Litvak V, Price CJ, Moran RJ., Lambert C. (2020) Second waves, social distancing, and the spread of COVID-19 across America. Wellcome Open Res 2020, 5:103 (doi.org/10.12688/wellcomeopenres.15986.1). IF 1.9

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizau J, Hulme OJ, Billig AJ, Litvak V, Price CJ, Moran RJ, Lambert C. (2020) Dynamic causal modelling of COVID-19. Wellcome Open Res 2020, 5:89. IF 1.9

Friston KJ, Parr T, Zeidman P, Razi A, Flandin G, Daunizau J, Hulme OJ, Billig AJ., Litvak V, Price CJ., Moran RJ., Costello A, Pillay D, Lambert C. (2020) Testing and tracking in the UK: A dynamic causal modelling study. Wellcome Open Research 5 (144), 144. IF 1.9 

Hulme OJ, Morville T, Gutkin B. (2019) Neurocomputational Theories of Homeostatic Control. Physics of Life Reviews, Jul 19. pii: S1571-0645(19)30100-9. doi: 10.1016/j.plrev.2019.07.005. IF 13.8

Hulme OJ, Webb EJ, Sebald A. (2019) An Introduction to Physiological Economics. Handbook of Research Methods and Applications in Experimental Economics, Edward Elgar Publishing.

Hulme OJ, Kvitsiani D. (2019) Extending Models of How Foraging Works: Uncertainty, Controllability, and Survivability. Behavioral and Brain Sciences 2019 Jan;42:e43. doi: 10.1017/S0140525X18002017. IF 20.7 

Hallsson BG, Siebner HR, Hulme OJ. (2018) Fairness, fast and slow: A review of dual process models of fairness. Neuroscience and Biobehavioral Reviews. Jun;89:49-60. doi: 10.1016/j.neubiorev.2018.02.016. IF 10.0

Christensen BJ, Schmidt JB, Nielsen MS, Tækkerd L, Holm L, Lunn S, Brediee WLP, Ritz C, Holst JJ, Hansenf T, Hilbert A, le Roux CW, Hulme OJ, Siebner HR, Morville T, Naver L, Floyd, AK, Sjödin A. (2018) Patient profiling for success after weight loss surgery: An interdisciplinary study protocol. Contemporary Clinical Trials Communications. Feb 17;10:121-130. doi: 10.1016/j.conctc.2018.02.002. IF 2.1

Larsen KM, Mørup M,  Birknow MR, Fischer E, Hulme OJ,  Vangkilde A, Schmock H, Baaré WF, Didriksen M, Olsen L, Werge T, Siebner HR, Garrido MI. (2018) Altered auditory processing and top-down connectivity in 22q11.2 Deletion Syndrome. Schizophrenia Research. Jan 30. pii: S0920-9964(18)30048-3. doi: 10.1016/j.schres.2018.01.026. IF 3.9

Meder D, Kolling N, Verhagen L, Wittmann MK, Scholl J, Madsen KH, Hulme OJ, Behrens TEJ, Rushworth MFS. (2017) Simultaneous representation of a spectrum of dynamically changing value estimates during decision making. Nature Communications. Dec 5;8(1):1942. doi: 10.1038/s41467-017-02169-w. IF 12.4

Friis-Olivarius M, Hulme OJ, Skov M, Ramsøy TZ, Siebner HR. (2017) Imaging the Creative Unconscious: Reflexive Neural Responses to Objects in the Visual and Parahippocampal Region Predicts State and Trait Creativity. Scientific Reports. Oct 31;7(1):14420. doi: 10.1038/s41598-017-14729-7. IF 4.1

Hulme OJ, & Madsen KM. (2016) Reward and the Predictive Brain. The Predictive Brain (in Danish "Hjerne Forum"). IF n/a

*Meder D, *Haagensen B, Hulme OJ, Morville TM, Gelskov S, Herz D, Diomsina B, Christensen M, Madsen KM, Siebner HR. (2016) Tuning the Brake While Raising the Stake: Network Dynamics During Sequential Decision-Making. Journal of Neuroscience. May 11;36(19):5417-26. doi: 10.1523/jneurosci.3191-15.2016. IF 5.9

Meder D, Madsen KM, Hulme OJ, Siebner HR, (2016) Chasing Probabilities: Signaling negative and positive prediction errors across domains. Neuroimage. Jul 1;134:180-191. doi: 10.1016/j.neuroimage.2016.04.019. IF 6.5

Schmock H, Vangkilde A, Larsen KM, Fischer E, Birknow MR, Jepsen JR, Olesen C, Skovby F, Plessen KJ, Mørup M, Hulme O.J., Baaré WF, Didriksen M, Siebner HR, Werge T, Olsen L. (2015) The Danish 22q11 research initiative. BMC Psychiatry. Sep 17;15:220. doi: 10.1186/s12888-015-0594-7. IF 2.4

Laursen HR, Siebner HR, Haren T, Madsen K, Grønlund R, Hulme OJ, Henningsson S. (2014) Variation in the oxytocin receptor gene is associated with behavioral and neural correlates of empathic accuracy. Frontiers in Behavioural Neuroscience. Dec 5;8:423. doi: 10.3389/fnbeh.2014.00423. eCollection 2014. IF 3.1

Hulme OJ, Skov M, Chadwick M, Siebner HR, Ramsøy TZ.(2014) Sparse encoding of Associative Density in the Hippocampus. Neuroimage. Nov 15;102 Pt 2:458-64. doi: 10.1016/j.neuroimage.2014.07.020. IF 6.5

Chumbley, Köchli,  Hulme OJ, Stan Van Uum, Evan Russel, Koren, Engelman, Pizzagalli & Fehr (2014). Stress and reward: long term cortisol exposure predicts the strength of sexual preference. Physiology and Behavior. May 28;131:33-40. doi: 10.1016/j.physbeh.2014.04.013. IF 2.5

Herz DM, Christensen MS, Bruggemann N, Hulme OJ,  Ridderinkhof RK,  Madsen KH, Siebner HR.(2014) Motivational tuning of fronto-subthalamic connectivity facilitates control of action impulses. Journal of Neuroscience. Feb 26;34(9):3210-7. doi: 10.1523/jneurosci.4081-13.2014. IF 5.9

Herz DM, Hulme OJ, Florin E, Christensen, MS, Timmermann L, Siebner HR. (2013) Levodopa reinstates connectivity from prefrontal to premotor cortex during externally paced movement in Parkinson's disease. Neuroimage. Apr 15;90:15-23. doi: 10.1016/j.neuroimage.2013.11.023. IF 5.9

van der Vegt JPM., Hulme OJ, Zittel S, Madsen KH,  Weiss MM, Buhmann C, Bloem BR., Münchau A, Siebner HR. (2013) Attenuated neural response to gamble outcomes in drug-naive patients with Parkinson’s Disease. Brain. Apr;136(Pt 4):1192-203. doi: 10.1093/brain/awt027. IF 10.3

Bach D, Hulme OJ, Penny W, Dolan R. (2011) The Known Unknowns: Neural Representation of Second-order Uncertainty and Ambiguity. Journal of Neuroscience. Mar 30;31(13):4811-20. doi: 10.1523/JNEUROSCI.1452-10.2011. IF 5.9

Hulme OJ, Whiteley LE, Shipp S. (2010) Spatially Distributed Encoding of Covert Attentional Shifts in Human Thalamus. Journal of Neurophysiology.Dec;104(6):3644-56. doi: 10.1152/jn.00303.2010. IF 2.5 

Fleming S, Whiteley LE, Hulme OJ, Sahani MS, Dolan R. (2010) Effects of Category-specific Costs on Neural Systems for Perceptual Decision-making. Journal of Neurophysiology Jun;103(6):3238-47. doi: 10.1152/jn.01084.2009. IF 2.5

Kirk U, Hulme OJ, Skov M, Christensen MS. (2009) Modulation of aesthetic value by semantic context: an fMRI study. Neuroimage. Feb 1;44(3):1125-32. doi: 10.1016/j.neuroimage.2008.10.009. IF 6.5 

Hulme OJ, Friston KJ, Zeki S. (2009) Neural Correlates of Stimulus Reportability. Journal of Cognitive Neuroscience. Aug;21(8):1602-10. doi: 10.1162/jocn.2009.21119. IF 3.1 

Zeki S, Hulme OJ, Roulston B, Atiyah M. (2008) The encoding of temporally irregular and regular visual patterns in the human brain. PloS One. May 14;3(5):e2180. doi: 10.1371/journal.pone.0002180. 

Friston KJ, Chu C, Mourão-Miranda J, Hulme OJ, Rees G, Penny W, Ashburner J. (2008) Bayesian Decoding of Brain Images. Neuroimage. Jan 1;39(1):181-205. IF 6.5 

Hulme OJ, Whiteley LE. (2007) The “Mesh” as Evidence - Model Comparison and Alternative Interpretations of Feedback. Behavioural and Brain Sciences. Commentary on Block, Dec;30(5-6):481-99; discussion 499-548. doi: 10.1017/S0140525X07002786. IF 20.7

Hulme OJ, Zeki S. (2006) The Sightless View: Neural Correlates of Occluded Objects. Cerebral Cortex. May;17(5):1197-205. IF 8.3

Hulme OJ (2006). Visibility, invisibility and reportability. PhD thesis, University of London, University College London (United Kingdom)