+45 2339 1399
Senior Researcher
I have wide interests within computational biology, spanning from evolutionary theory, computational neuroscience, and neuroeconomics, through to physiology, ecology, and ethology.
The questions that preoccupy me pertain to the origins of reward value. Where do reward values come from? How are they configured evolutionarily, physiologically, and neurobiologically?
I employ a range of approaches from computational modelling, functional neuroimaging, behavioral and physiological experiments.
Research area "Cognitive and Computational Neuroscience" (Coordinator)
Reward and Homeostasis (Group Leader)
2006
PhD in Neuroimaging, University College London
2002
Special Student, Harvard University
2001
MA in Physiological Sciences, Oxford University
2011 - Present
Senior Researcher, Reward & Homeostasis Group, DRCMR
2008 - Present
Honorary Fellow, Department of Anatomy and Developmental Biology, UCL
2010 - 2011
Visiting Researcher, Psychology Department, University of British Columbia
2010 - 2011
Lecturer, Zoology Department & Psychology Department, University of British Columbia
2009 - 2009
Visiting Scholar, Welsh Institute of Cognitive Neuroscience
2007 - 2008
Wellcome Trust Postdoctoral Fellow in Cognitive Neuroscience, UCL
Larsen, K. M., Mørup, M., Birknow, M. R., Fischer, E., Hulme, O., Vangkilde, A., Schmock, H., Baaré, W. F. C., Didriksen, M., Olsen, L., Werge, T., Siebner, H. R. & Garrido, M. I. Altered auditory processing and effective connectivity in 22q11.2 deletion syndrome. Schizophrenia Research. 2020.
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Hulme, O. J. & Kvitsiani, D. Extending models of "How Foraging Works": Uncertainty, controllability, and survivability. Behavioral and Brain Sciences. 42, e43. 2019.
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Hulme, O. J., Morville, T. & Gutkin, B. Neurocomputational theories of homeostatic control. Physics of Life Reviews. 31, p. 214-232, 2019.
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Larsen, K. M., Mørup, M., Birknow, M. R., Fischer, E., Hulme, O., Vangkilde, A., Schmock, H., Baaré, W. F. C., Didriksen, M., Olsen, L., Werge, T., Siebner, H. R. & Garrido, M. I. (2018), Altered auditory processing and effective connectivity in 22q11.2 deletion syndrome. Schizophrenia research.
Hallsson, B. G., Siebner, H. R. & Hulme, O. J. (2018), Fairness, fast and slow: A review of dual process models of fairness. Neuroscience & Biobehavioral Reviews.
Morville, T., Siebner, H. R. & Hulme, O. J. (2017), Reward Prediction Errors and the Marginal Utility of Glucose under Fluctuating Glycemic States.
Meder, D., Kolling, N., Verhagen, L., Wittmann, M. K., Scholl, J., Madsen, K. H., Hulme, O. J., Behrens, T. E. J. & Rushworth, M. F. S. (2017), Simultaneous Representation of a Spectrum of Dynamically Changing Value Estimates during Decision Making. 2 p.
Meder, D., Kolling, N., Verhagen, L., Wittmann, M. K., Madsen, K. H., Hulme, O. J., Behrens, T. E. J., Siebner, H. R. & Rushworth, M. F. (2017), Simultaneous Representation of a Spectrum of Dynamically Changing Value Estimates. 2017.
Meder, D., Kolling, N., Verhagen, L., Wittmann, M. K., Scholl, J., Madsen, K. H., Hulme, O. J., Behrens, T. E. J. & Rushworth, M. F. S. (2017), Simultaneous representation of a spectrum of dynamically changing value estimates during decision making. Nature Communications. 8, 1942 2017.
Friis-Olivarius, M., Hulme, O. J., Skov, M., Ramsøy, T. Z. & Siebner, H. R. (2017), Imaging the Creative Unconscious: Reflexive Neural Responses to Objects in the Visual and Parahippocampal Region Predicts State and Trait Creativity. Scientific Reports. 7, p. 1-8, 14420.
Morville, T. & Hulme, O. J. (2016), Dynamics of Death and Decision making.
Meder, D., Kolling, N., Verhagen, L., Wittmann, M. K., Madsen, K. H., Hulme, O. J., Behrens, T. E. J. & Rushworth, M. F. (2016), Simultaneous and Dynamic Representations of Learning Rates in the Human Brain. 1 p.
Hulme, O. J., Baladi Nejad, A., Haren, T., Henningsson, S., Madsen, K. H. & Siebner, H. R. (2016), Psycho-Psychophysics: The Superior Temporal Sulcus and the Reflexive Decoding of Pain.
Hulme, O.J, & Madsen, K.M. Reward and the Predictive Brain, in “ The Predictive Brain”
*Meder, D., *Haagensen, B., Hulme, O.J., Morville, T.M., Gelskov, S., Herz, D., Diomsina, B., Christensen, M., Madsen, K.M., Siebner, H.R., (Forthcoming) Tuning the Brake While Raising the Stake: Network Dynamics During Sequential Decision-Making Journal of Neuroscience.
Meder, D., Madsen, K.M., Hulme, O.J., Siebner, H.R., (Forthcoming) Chasing probabilities – Signaling negative and positive prediction errors across domains. Neuroimage
Schmock H, Vangkilde A, Larsen KM, Fischer E, Birknow MR, Jepsen JR, Olesen C, Skovby F, Plessen KJ, Mørup M, Hulme O, Baaré WF, Didriksen M, Siebner HR, Werge T, Olsen L. (2015) The Danish 22q11 research initiative. BMC Psychiatry
Laursen, H.R., Siebner, H.R, Haren, T., Madsen, K., Grønlund, R., Hulme, O.J., Henningsson, S., (2014) Variation in the OXTR gene is associated with behavioral and neural correlates of empathic accuracy. Frontiers in Behavioural Neuroscience
Hulme,O.J., Skov, M., Chadwick M., Siebner, H.R., Ramsøy, T.Z.(2014) Sparse encoding of Associative Density in the Hippocampus Neuroimage
Chumbley, Köchli, Hulme, Stan Van Uum, Evan Russel, Koren, Engelman, Pizzagalli & Fehr (2014) Stress and reward: long term cortisol exposure predicts the strength of sexual preference Physiology and Behavior
Herz, D.M., Christensen, M.S., Bruggemann, N., Hulme, O. J., Ridderinkhof, R.K., Madsen, K.H., Siebner, H.R.,(2014) Motivational tuning of fronto-subthalamic connectivity facilitates control of action impulses. Journal of Neuroscience
Herz, D.M., Hulme, O.J., Florin, E., Christensen, M.S., Timmermann, L., Siebner, H.R., (2013) Levodopa reinstates connectivity from prefrontal to premotor cortex during externally paced movement in Parkinson's disease. Neuroimage
van der Vegt, J.P.M., Hulme, O.J., Zittel, S., Madsen, K.H., Weiss, M.M., Buhmann, C., Bloem, B.R., Münchau, A., Siebner (2013) Attenuated neural response to gamble outcomes in drug-naive patients with Parkinson’s Disease. Brain
Bach, D., Hulme, O., Penny, W., and Dolan, R. (2011). The Known Unknowns: Neural Representation of Second-order Uncertainty and Ambiguity. Journal of Neuroscience.
Hulme, O.J., Whiteley, L.E., and Shipp, S. (2010). Spatially Distributed Encoding of Covert Attentional Shifts in Human Thalamus. Journal of Neurophysiology.
Fleming, S., Whiteley, L.E., Hulme, O., Sahani, S., and Dolan, R., (2010). Effects of Category-specific Costs on Neural Systems for Perceptual Decision-making. Journal of Neurophysiology.
Kirk, U., Hulme, O.J., Skov, M., and Christensen, M.S. (2009). Modulation of aesthetic value by semantic context: an fMRI study.. Neuroimage.
Hulme, O.J. Friston, K. and Zeki, S. (2009). Neural Correlates of Stimulus Reportability. Journal of Cognitive Neuroscience.
Zeki, S., Hulme, O.J., Roulston, B., and Atiyah, M. (2008). The encoding of temporally irregular and regular visual patterns in the human brain.. Plos One.
Friston, K., Chu, C., Mourão-Miranda, J., Hulme, O.J, Rees, G., Penny, W., and Ashburner, J. (2008). Bayesian Decoding of Brain Images. Neuroimage.
Hulme, O.J., and Whiteley, L. (2007). The “Mesh” as Evidence - Model Comparison and Alternative Interpretations of Feedback. Behavioural and Brain Sciences.
Hulme, O.J. and Zeki, S. (2006). The Sightless View: Neural Correlates of Occluded Objects. Cerebral Cortex.