Physical Resources

Friday, 05 January 2007 14:30

Physical Resources

The current equipment of the center includes the following:

Philips Achieva 7.0T	7T scanner installed after generous donations from the John and Birthe Meyer Foundation and the Danish Research Councils

Siemens Verio 3.0T	A wide-bore high-end scanner with multi-nuclear capabilities installed 2010.

Siemens Avanto 1.5T	A classic multi-channel general purpose scanner installed 2010.

Siemens Trio 3.0T	This scanner was installed in 2002 after a generous donation from the Simon Spies Foundation.

Philips Achieva 3.0T	This scanner installed 2013 for research purposes got installed in connection with the 7T project.

Varian Inova 4.7T	This highly flexible experimental scanner is used for animal and "in vitro" work. The system has undergone a number of upgrades and is up-to-date with parallel imaging capability.

Oxford HyperSense hyperpolarisation unit	A generous donation from the Simon Spies Foundation (description in Danish). The department has a research agreement with GE Healthcare and does in vivo studies of metabolism using hyperpolarised 13C-labelled pyruvate, for example.

EEG, neuronavigation, TMS	Excellent facilities for advanced neuroimaging studies.

Animal laboratory	The department has good facilities and skillful staff.

Computer laboratory	The analysis of MR images is very computer intensive and is performed using a cluster of fast computers.

Hardware lab	RF and hardware workshop for coil building and more.

Written by Lise Skjold Andersen

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The current equipment of the center includes the following:

Philips Achieva 7.0T	7T scanner installed after generous donations from the John and Birthe Meyer Foundation and the Danish Research Councils

Siemens Verio 3.0T	A wide-bore high-end scanner with multi-nuclear capabilities installed 2010.

Siemens Avanto 1.5T	A classic multi-channel general purpose scanner installed 2010.

Siemens Trio 3.0T	This scanner was installed in 2002 after a generous donation from the Simon Spies Foundation.

Philips Achieva 3.0T	This scanner installed 2013 for research purposes got installed in connection with the 7T project.

Varian Inova 4.7T	This highly flexible experimental scanner is used for animal and "in vitro" work. The system has undergone a number of upgrades and is up-to-date with parallel imaging capability.

Oxford HyperSense hyperpolarisation unit	A generous donation from the Simon Spies Foundation (description in Danish). The department has a research agreement with GE Healthcare and does in vivo studies of metabolism using hyperpolarised 13C-labelled pyruvate, for example.

EEG, neuronavigation, TMS	Excellent facilities for advanced neuroimaging studies.

Animal laboratory	The department has good facilities and skillful staff.

Computer laboratory	The analysis of MR images is very computer intensive and is performed using a cluster of fast computers.

Hardware lab	RF and hardware workshop for coil building and more.

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Lise Skjold Andersen

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Selected Publications

Madsen MAJ, Wiggermann V, Bramow S, Christensen JR, Sellebjerg F, Siebner HR. 2021. Imaging cortical multiple sclerosis lesions with ultra-high field MRI. NeuroImage. Clinical. 32:1-14. https://doi.org/10.1016/j.nicl.2021.102847

Chow HH, Talbot J, Marstrand L, Lundell H, Roman Siebner H, Bach Søndergaard H, Sellebjerg F. 2021. Smoking, cardiovascular risk factors and LRP2 gene variation: Associations with disease severity, cognitive function and brain structure in primary progressive multiple sclerosis. Multiple Sclerosis and Related Disorders. 56:1-7. https://doi.org/10.1016/j.msard.2021.103296

Ruiu E, Dubbioso R, Madsen KH, Svolgaard O, Raffin E, Andersen KW, Karabanov AN, Siebner HR. 2020. Probing Context-Dependent Modulations of Ipsilateral Premotor-Motor Connectivity in Relapsing-Remitting Multiple Sclerosis. Frontiers in Neurology. 11:1-10. Available from: 10.3389/fneur.2020.00193

Bauer C, Dyrby TB, Sellebjerg F, Madsen KS, Svolgaard O, Blinkenberg M, Siebner HR, Andersen KW. 2020. Motor fatigue is associated with asymmetric connectivity properties of the corticospinal tract in multiple sclerosis. NeuroImage. Clinical. 28:1-12. Available from: 10.1016/j.nicl.2020.102393

Lundell, H., Svolgaard, O., Dogonowski, A-M., Romme Christensen, J., Selleberg, F., Soelberg Sørensen, P., Blinkenberg, M., Siebner, H. R. & Garde, E.
Spinal cord atrophy in anterior-posterior direction reflects impairment in multiple sclerosis.
Acta Neurologica Scandinavica. 136, 4, p. 330-337, 2017.

Schreiber K, Magyari M, Sellebjerg F, Iversen P, Garde E, Gøbel Madsen C, Börnsen L, Christensen JR, Ratzer R, Siebner HR, Laursen B, Soelberg Sorensen P. High-dose erythropoietin in patients with progressive multiple sclerosis: a randomized, placebo controlled, phase 2 trial. Mult Scler 2016: Epub ahead of print.

Dogonowski AM, Blinkenberg M, Paulson OB, Sellebjerg F, Soelberg Sørensen P, Siebner HR, Madsen KH. Recovery from an acute relapse is associated with changes in motor resting-state connectivity in multiple sclerosis. J Neurol Neurosurg Psychiatry 2016;87:912-914.

Ratzer R, Iversen P, Börnsen L, Dyrby T, Romme Christensen J, Ammitzbøll C, Madsen C, Garde E, Lyksborg M, Andersen B, Hyldstrup L, Soelberg Sørensen P, Siebner HR, Sellebjerg F. Monthly oral methylprednisolone pulse treatment in progressive multiple sclerosis. Mult Scler 2016;22:926-934.

Voldsgaard A, Bager P, Garde E, Åkeson P, Leffers AM, Kapel C, Roepstorff A, Thamsborg SM, Melbye M, Siebner H, Søndergaard HB, Sellebjerg F, Soelberg Sørensen P. Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect. Mult Scler 2015;21:1723-1729.

Weier K, Banwell B, Cerasa A, Collins DL, Dogonowski AM, Lassmann H, Quattrone A, Sahraian MA, Siebner HR, Sprenger T. The role of the cerebellum in multiple sclerosis. Cerebellum 2015;14:364-374.

Christensen JR, Ratzer R, Börnsen L, Lyksborg M, Garde E, Dyrby TB, Siebner HR, Sorensen PS, Sellebjerg F. Natalizumab in progressive MS: Results of an open-label, phase 2A, proof-of-concept trial. Neurology 2014;82:1499-1507.

Lyksborg M, Siebner HR, Sørensen PS, Blinkenberg M, Parker GJM, Dogonowski A, Garde E, Larsen R, Dyrby TB. Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity. PLOS ONE 2014;9, e95540.

Christensen JR, Ratzer R, Börnsen L, Lyksborg M, Garde E, Dyrby TB, Siebner HR, Sørensen PS, Sellebjerg F. Natalizumab in progressive MS – results of an open-label phase 2A proof-of- concept trial. Neurology 2014;82:1499-1507.

Dogonowski, A.-M., Andersen, K. W., Madsen, K. H., Sørensen, P. S., Paulson, O. B., Blinkenberg, M., & Siebner, H. R. Multiple sclerosis impairs regional functional connectivity in the cerebellum. NeuroImage: Clinical, 2014, 4:130–138.