MRI is an important tool for the diagnosis and monitoring of multiple sclerosis (MS). However, there is a generally weak correlation between conventional MRI-based measures of MS lesion burden and clinical disability. DRCMR MS-group employs advanced MRI techniques with improved specificity and sensitivity to investigate the diffused lesions and pathophysiological mechanisms of MS. The newer MRI methods include: functional MRI (fMRI), functional connectivity MRI (fcMRI), magnetic resonance spectroscopy (MRS), and diffusion weighted imaging (DWI). The research projects are performed in collaboration with the Danish Multiple Sclerosis Research Center (DMSC), and supported by the Danish MS foundation.