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Tim Dyrby



+45 3862 6542




Image Analysis and Computer Graphics section, DTU Compute

Research Interests

My main interest is microstructure plasticity imaging in normal and diseased conditions. How to non-invasively map microstructural features of brain tissue i.e. to statistically model measures of axon diameter and density, as well as general anisotropic measures. To understand the architecture of the microstructural environment and its connectivity that impact microstructural imaging and modeling. Key imaging technology is diffusion MRI where we design and combine acquisitions to reflect specific microstructural features. Diffusion MRI is translational so I work with powerful preclinical MRI scanners to develop, test and validate new diffusion MRI acquisitions and apply them to human patient studies.

Curriculum Vitae



PhD: DTU informatics, Technical Uni. Denmark (DTU), DK


MSc: DTU informatics, Technical Uni. Denmark (DTU), DK


BSc.E.E: Dep. of Electronic, Engineering College of Copenhagen, DK


Elektroniktekniker, Frederiksberg Tekniske Skole, DK


2015 - Present

Associate Professor in multi-modal imaging, Image Analysis and Computer Graphics section, DTU compute

2014 - Present

Head of Preclinical research, DRCMR , Cph. Uni. Hosp.,Hvidovre, DK

2010 - Present

Senior Researcher, DRCMR, Cph. Uni. Hosp.,Hvidovre, DK

2009 - Present

Group leader of the Diffusion Imaging Group (DIG), DRCMR, Cph. Uni. Hosp.,Hvidovre, DK

2009 - 2010

Postdoc, DRCMR, Cph. Uni. Hosp.,Hvidovre, DK


Ambrosen, K. S., Eskildsen, S. F., Hinne, M., Krug, K., Lundell, H., Schmidt, M. N., van Gerven, M. A. J., Mørup, M. & Dyrby, T. B.
Validation of structural brain connectivity networks: The impact of scanning parameters.
NeuroImage. 204, p. 1-13, 116207. 2020.
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Nath, V., Schilling, K. G., Parvathaneni, P., Huo, Y., Blaber, J. A., Hainline, A. E., Barakovic, M., Rafael-Patino, J., Frigo, M., Girard, G., Thiran, J-P., Daducci, A., Rowe, M., Rodrigues, P., Prčkovska, V., Aydogan, D. B., Sun, W., Shi, Y., Parker, W. A., Ould Ismail, A. A., Verma, R., Cabeen, R. P., Toga, A. W., Newton, A. T., Wasserthal, J., Neher, P., Maier-Hein, K., Savini, G., Palesi, F., Kaden, E., Wu, Y., He, J., Feng, Y., Paquette, M., Rheault, F., Sidhu, J., Lebel, C., Leemans, A., Descoteaux, M., Dyrby, T. B., Kang, H. & Landman, B. A.
Tractography reproducibility challenge with empirical data (TraCED): The 2017 ISMRM diffusion study group challenge.
Journal of magnetic resonance imaging : JMRI. 51, 1, p. 234-249, 2020.
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Andreasen, S. H., Andersen, K. W., Conde, V., Dyrby, T. B., Puonti, O. T., Kammersgaard, L. P., Madsen, C. G., Madsen, K. H., Poulsen, I. & Siebner, H. R.
Limited co-localization of microbleeds and microstructural changes after severe traumatic brain injury.
Journal of Neurotrauma. 2020.
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Barrett, R. L. C., Dawson, M., Dyrby, T. B., Krug, K., Ptito, M., D'Arceuil, H., Croxson, P. L., Johnson, P., Howells, H., Forkel, S. J., Dell'Acqua, F. & Catani, M.
Differences in frontal network anatomy across primate species.
The Journal of Neuroscience. 25 p., 1650-18. 2020
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Postans, M., Parker, G. D., Lundell, H., Ptito, M., Hamandi, K., Gray, W. P., Aggleton, J. P., Dyrby, T. B., Jones, D. K. & Winter, M.
Uncovering a Role for the Dorsal Hippocampal Commissure in Recognition Memory.
Cerebral Cortex. 15 p., bhz143. 2020.
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Romascano, D., Barakovic, M., Rafael-Patino, J., Dyrby, T. B., Thiran, J-P. & Daducci, A.
ActiveAxADD: Toward non-parametric and orientationally invariant axon diameter distribution mapping using PGSE.
Magnetic Resonance in Medicine. 2020.
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Alexander, D. C., Dyrby, T. B., Nilsson, M. & Zhang, H.
Imaging brain microstructure with diffusion MRI: practicality and applications.
N M R in Biomedicine. 32, 4, p. 1-26, e3841. 2019.
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Borg, L., Sporring, J., Dam, E. B., Dahl, V. A., Dyrby, T. B., Feidenhans'l, R., Dahl, A. B. & Pingel, J.
Muscle fibre morphology and microarchitecture in cerebral palsy patients obtained by 3D synchrotron X-ray computed tomography.
Computers in Biology and Medicine. 107, p. 265-269, 2019.
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Innocenti, G. M., Caminiti, R., Rouiller, E. M., Knott, G., Dyrby, T. B., Descoteaux, M. & Thiran, J-P.
Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey.
Cerebral Cortex. 29, 2, p. 788-801, 2019.
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Innocenti, G. M., Dyrby, T. B., Girard, G., St-Onge, E., Thiran, J-P., Daducci, A. & Descoteaux, M.
Topological principles and developmental algorithms might refine diffusion tractography.
Brain structure & function. 224, 1, p. 1-8, 2019.
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Lundell, H., Nilsson, M., Dyrby, T. B., Parker, G. J. M., Cristinacce, P. L. H., Zhou, F-L., Topgaard, D. & Lasič, S.
Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail.
Scientific Reports. 9, 1, p. 1-12, 9026. 2019.
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Sarubbo, S., Petit, L., De Benedictis, A., Chioffi, F., Ptito, M. & Dyrby, T. B.
Uncovering the inferior fronto-occipital fascicle and its topological organization in non-human primates: the missing connection for language evolution.
Brain structure & function. 224, 4, p. 1553-1567, 2019.
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Schilling, K. G., Nath, V., Hansen, C., Parvathaneni, P., Blaber, J., Gao, Y., Neher, P., Aydogan, D. B., Shi, Y., Ocampo-Pineda, M., Schiavi, S., Daducci, A., Girard, G., Barakovic, M., Rafael-Patino, J., Romascano, D., Rensonnet, G., Pizzolato, M., Bates, A., Fischi, E., Thiran, J-P., Canales-Rodríguez, E. J., Huang, C., Zhu, H., Zhong, L., Cabeen, R., Toga, A. W., Rheault, F., Theaud, G., Houde, J-C., Sidhu, J., Chamberland, M., Westin, C-F., Dyrby, T. B., Verma, R., Rathi, Y., Irfanoglu, M. O., Thomas, C., Pierpaoli, C., Descoteaux, M., Anderson, A. W. & Landman, B. A.
Limits to anatomical accuracy of diffusion tractography using modern approaches.
NeuroImage. 185, p. 1-11, 2019.
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Innocenti, G. M., Caminiti, R., Rouiller, E. M., Knott, G., Dyrby, T. B., Descoteaux, M. & Thiran, J-P. Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey. Cerebral Cortex. 2018.

Alexander, D. C., Dyrby, T. B., Nilsson, M. & Zhang, H. Imaging brain microstructure with diffusion MRI: practicality and applications. N M R in Biomedicine. 2018.

Sickmann, H. M., Skoven, C., Bastlund, J. F., Dyrby, T. B., Plath, N., Kohlmeier, K. A. & Kristensen, M. P. Sleep patterning changes in a prenatal stress model of depression. Journal of Developmental Origins of Health and Disease. 9, 1, p. 102-111, 2018.

Nielsen, J. S., Dyrby, T. B. & Lundell, H. Magnetic resonance temporal diffusion tensor spectroscopy of disordered anisotropic tissue. Scientific Reports. 8, 2930 2018.

Lasič, S., Lundell, H., Topgaard, D. & Dyrby, T. B. Effects of imaging gradients in sequences with varying longitudinal storage time-Case of diffusion exchange imaging. Magnetic Resonance in Medicine. 79, p. 2228-2235, 2018.

Teh, I., Schneider, J. E., Whittington, H. J., Dyrby, T. B. & Lundell, H. M. H. Temporal Diffusion Spectroscopy in the Heart with Oscillating Gradients. 2017.

Skoven, C., Kvitsiani, D., Pakkenberg, B., Siebner, H. R. & Dyrby, T. B. Illuminating the Neurobiological Mechanisms of Non-invasive Transcranial Brain Stimulation (NTBS) Techniques. 2017.

Romascano, D., Barakovic, M., Auria, A., Dyrby, T. B., Thiran, J-P. & Daducci, A. Orientation-invariant and non-parametric Axon Diameter Distribution mapping using PGSE and regularized discrete linear modeling. 2017.

Lundell, H. M. H., Nilsson, M., Dyrby, T. B., Parker, G. J. M., Cristinacce, P. L. H., Zhou, F., Topgaard, D. & Lasic, S. Microscopic anisotropy with spectrally modulated q-space trajectory encoding. 2017.

Lundell, H. M. H., Ingo, C., Dyrby, T. B. & Ronen, I. Accurate estimation of intra-axonal diffusivity and anisotropy of NAA in humans at 7T. 2017.

Boer, V. O., Lundell, H. M. H., Dyrby, T. B., Ronen, I. & Petersen, E. T. Dual Voxel Diffusion Weighted MR-Spectroscopy. 2017.

Reislev, N. H., Dyrby, T. B., Siebner, H. R., Lundell, H., Ptito, M. & Kupers, R. Thalamocortical Connectivity and Microstructural Changes in Congenital and Late Blindness. Neural Plasticity. 2017, p. 9807512, 2017.

Maier-Hein, K. H., Neher, P. F., Houde, J-C., Côté, M-A., Garyfallidis, E., Zhong, J., Chamberland, M., Yeh, F-C., Lin, Y-C., Ji, Q., Reddick, W. E., Glass, J. O., Chen, D. Q., Feng, Y., Gao, C., Wu, Y., Ma, J., Renjie, H., Li, Q., Westin, C-F., Deslauriers-Gauthier, S., González, J. O. O., Paquette, M., St-Jean, S., Girard, G., Rheault, F., Sidhu, J., Tax, C. M. W., Guo, F., Mesri, H. Y., Dávid, S., Froeling, M., Heemskerk, A. M., Leemans, A., Boré, A., Pinsard, B., Bedetti, C., Desrosiers, M., Brambati, S., Doyon, J., Sarica, A., Vasta, R., Cerasa, A., Quattrone, A., Yeatman, J., Khan, A. R., Hodges, W., Alexander, S., Romascano, D., Barakovic, M., Auría, A., Esteban, O., Lemkaddem, A., Thiran, J-P., Cetingul, H. E., Odry, B. L., Mailhe, B., Nadar, M. S., Pizzagalli, F., Prasad, G., Villalon-Reina, J. E., Galvis, J., Thompson, P. M., Requejo, F. D. S., Laguna, P. L., Lacerda, L. M., Barrett, R., Dell'Acqua, F., Catani, M., Petit, L., Caruyer, E., Daducci, A., Dyrby, T. B., Holland-Letz, T., Hilgetag, C. C., Stieltjes, B. & Descoteaux, M. The challenge of mapping the human connectome based on diffusion tractography.
Nature Communications. 8, 1349 2017.

Innocenti, G. M., Dyrby, T. B., Andersen, K. W., Rouiller, E. M. & Caminiti, RThe Crossed Projection to the Striatum in Two Species of Monkey and in Humans: Behavioral and Evolutionary Significance. Cerebral Cortex. 27, 6, p. 3217-3230, 2017.

Catani, M., Robertsson, N., Beyh, A., Huynh, V., de Santiago Requejo, F., Howells, H., Barrett, R. L. C., Aiello, M., Cavaliere, C., Dyrby, T. B., Krug, K., Ptito, M., D'Arceuil, H., Forkel, S. J. & Dell'Acqua, F. Short parietal lobe connections of the human and monkey brain. Cortex. 97, p. 339-357, 2017.

Ammitzbøll, C., Dyrby, T. B., Lyksborg, M., Schreiber, K., Ratzer, R., Romme Christensen, J., Iversen, P., Magyari, M., Garde, E., Sørensen, P. S., Siebner, H. R. & Sellebjerg, F. Disability in progressive MS is associated with T2 lesion changes. Multiple Sclerosis and Related Disorders. 20, p. 73-77, 2017.

Alexander, D. C., Zikic, D., Ghosh, A., Tanno, R., Wottschel, V., Zhang, J., Kaden, E., Dyrby, T. B., Sotiropoulos, S. N., Zhang, H. & Criminisi, A. Image quality transfer and applications in diffusion MRI. NeuroImage. 152, 5, p. 283-298, 2017.

Teh, I., Lundell, H. M. H., Whittington, H. J., Dyrby, T. B. & Scneider, J. E., Resolving Microscopic Fractional Anisotropy in the Heart. 1 p., 2016.

Skoven, C., Sickman, H. M., Bastlund, J. F., Dyrby, T. B., Plath, N., Kohlmeier, K. A. & Kristensen, M. P. Sleep Changes in a Rat Prenatal Stress Model of Depression. 2016.

Magnusson, O. P., Jensen, P. R., Dyrby, T. B., Karlsson, M., Lerche, M. H. & Hanson, L. G., Single- Shot-RARE for rapid 3D hyperpolarized metabolic ex vivo tissue imaging: RF-pulse design for semi-dense spectra. 1 p., 2016.

Lasic, S., Jespersen, S. N., Lundell, H. M. H., Nilsson, M., Dyrby, T. B. & Topgaard, D., Apparent Exchange Rate in Multi-compartment Anisotropic Tissue. 1 p., 2016.

Bauer, C., Andersen, K. W., Svolgaard, O. M. R., Sellebjerg, F. T., Madsen, K. S., Madsen, K. H., Dyrby, T. B. & Siebner, H. R., Microstructural white matter correlates of motor fatigue in multiple sclerosis: a diffusion weighted imaging study. 2016.

Bauer, C., Andersen, K. W., Svolgaard, O. M. R., Madsen, K. H., Dyrby, T. B., Sellebjerg, F. T. & Siebner, H. R., Is there a regional structural correlate of motor fatigue in multiple sclerosis?: a Magnetic Resonance Imaging study.

Andersen, K. W., Madsen, K. H., Dyrby, T. B. & Siebner, H. R., Multi Voxel Pattern Analysis (MVPA) classification reveals distributed neural presentations of specific finger movement sequences in the human striatum: a task-based functional MRI study. 2016.

Andersen, K. W., Madsen, K. H., Dyrby, T. B. & Siebner, H. R., Shift of finger sequence representations in the human basal ganglia during motor learning. 2016.

Innocenti, G. M., Carlén, M. & Dyrby, T. B., Axons and Brain Architecture: The Diameters of Cortical Axons and Their Relevance to Neural Computing. Axons and Brain Architecture. Elsevier, p. 319-337, 2016.

Large I, Bridge H, Ahmed B, Clare S, Kolasinski J, Lam WW, Miller KL, Dyrby TB, Parker AJ, Smith JET, Daubney G, Sallet J Bell AH, Krug K, Individual differences in the alignment of structural and functional markers of the V5/MT complex in primates, Cerebral Cortex, 2016, Accepted

Donahue C, Sotiropoulos S, Jbabdi S, Hernandez-Fernandez M, Beherens T, Dyrby TB, Kennedy H, Knoblauch K, Coalson T, Glasser M, Van Essen D, Using Diffusion Tractography to Predict Cortical Connection Strength and Distance: A Quantitative Comparison with Tracers in the Monkey, Journal Neuroscience, 2016, Accepted 

Innocenti GM, Dyrby TB, Winther-Andersen K , Rouillier EM, Caminiti R, The crossed projection to the striatum in two species of monkey and in humans: Behavioral and evolutionary significance, Cerebral Cortex accepted

Reislev, N. L., Dyrby, T. B., Siebner, H. R., Kupers, R. & Ptito, M.Simultaneous assessment of white matter changes in microstructure and connectedness in the blind brain.
Neural Plasticity. 2016, p. 1-12, Article ID 6029241 2016.

Ratzer R, Iversen P, Börnsen L, Dyrby TB, Christensen JR, Ammitzbøll C, Madsen CG, Garde E, Andersen B, Hyldstrup L, Sørensen PS, Siebner HR, Sellebjerg F, Monthly oral methylprednisolone pulse treatment in progressive multiple sclerosis, Multiple Sclerosis Journal, (Accepted)

Shemesh, N., Jespersen, S. N., Alexander, D. C., Cohen, Y., Drobnjak, I., Dyrby, T. B., Finsterbusch, J., Koch, M., Kuder, T., Laun, F., Lawrenz, M., Lundell, H., Mitra, P. P., Nilsson, M., Özarslan, E., Topgaard, D. & Westin, C-F., Conventions and nomenclature for double diffusion encoding NMR and MRI. Magnetic Resonance in Medicine. 75, 1, p. 82-87, 2016.

Knösche TR, Anwander A, Liptrot MG, Dyrby TB, Validation of Tractography – Comparison with Manganese Tracing, Human Brain Mapping (Accepted), 2015

Reislev, N. L., Kupers, R., Siebner, H. R., Ptito, M. & Dyrby, T. B., Blindness alters the microstructure of the ventral but not the dorsal visual stream. Brain structure & function. 221, 6, s. pp 2891-2903 13 p., 2016.

Sickmann HM, Arentzen TS, Dyrby TB, Plath N, Kristensen MP, Prenatal Stress Produces Sex Specific Changes in Depression-like Behavior in Rats: Implications for increased vulnerability in females. Journal of Developmental Origins of Health and Disease, 2015, 6:462-74.

Daducci A, Canales-Rodriguez EJ, Zhang H, Dyrby TB, Alexander DC, Thiran JP, Accelerated Microstructure Imaging via Convex Optimization (AMICO) from diffusion MRI data, Neuroimage, 35, 32-44, 2015

Lundell HM, Sønderby CK, Dyrby TB, Diffusion weighted imaging with circularly polarized oscillating gradients, Magn Reson Med., 73(3), 171:1176, 2015

Dyrby TB, Lundell H, Burke MW, Reislev NL, Paulson OB, Ptito M, Siebner HR, Interpolation of diffusion weighted imaging datasets, NeuroImage,103, 202-213, 2014

Jespersen SN, Lundel H, Sønderby C, Dyrby TB, Commentary on ”Microanisotropy imaging: quantification of microscopic diffusion anisotropy and orientation of order parameter by diffusion MRI with magic-angle spinning of the q-vector”, Frontiers in Physics, doi: 10.3389/fphy.2014.00028, 2014

Lundell HM, Alexander DC, Dyrby TB, High angular resolution diffusion imaging with stimulated echoes: compensation and correction in experiment design and analysis, NMR in Biomedicine, 27 (8), 918-925, 2014

Liptrot MG, Sidaros K, Dyrby TB, Addressing The Path-Length-Dependency Confound In White Matter Tract Segmentation, PlosOne, 9 (5), e96247, 2014

Lyksborg M, Siebner HR, Sørensen PS, Blinkenberg M, Parker GJM, Dogonowski A, Garde E, Larsen R, Dyrby TB, Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity, PlosOne, 9 (4), e95540, 2014

Christensen JR, Ratzer R, Börnsen L, Lyksborg M, Garde E, Dyrby TB, Siebner HR, Sørensen PS, Sellebjerg F, Natalizumab in progressive MS – results of an open-label phase 2A proof-of- concept trial. Neurology, 2014 

Sønderby CK, Lundell HM, Søgaard LV, Dyrby TB, Apparent exchange rate imaging in anisotropic systems, Magn Reson Med., 72 (3), 756:762, 2014

Jespersen SN, Lundell H, Sønderby KS, Dyrby TB, Rotationally invariant sampling of double pulsed field gradient diffusion: estimating apparent compartment eccentricity, NMR in biomedicine, 2013

Assaf Y, Alexander DC, Jones DK, Bizzi A, Behrens T, Clark C, Cohen Y, Dyrby TB, Huppi P, Knoesche T, LeBihan D, Parker GJM, CONNECT Consortium, The CONNECT project: Combining Macro- and Micro-structure, NeuroImage, 2013

Dogonowski AM, Siebner HR, Sørensen PS, Paulson OB, Dyrby TB, Blinkenberg M, Madsen KH, Resting-state connectivity of premotor cortex reflects disability in multiple sclerosis, Acta Neurologica Scandinavica, , 2013 

Dogonowski A, Siebner HR, Sørensen PS, Wu X, Biswal B, Paulson OB, Dyrby TB, Skimminge A, Blinkenberg M, Madsen KH, Expanded functional coupling of subcortical nuclei with the motor resting-state network in multiple sclerosis, Multiple Sclerosis Journal, 19: 559-566, 2013

Dyrby TB, Søgaard LV, Hall MG, Ptito M, Alexander DC, Contrast and stability of the axon diameter index from microstructure imaging with diffusion MRI, Magn Reson Med., 70(3), 711:721, 2013

Lundell H, Barthelemy D, Biering-Sørensen F, Cohen-Adad J, Nielsen JB, Dyrby TB, Fast diffusion tensor imaging and tractography of the whole cervical spinal cord using point spread function corrected echo planar imaging., Magn Reson Med. 69(1):144-9. 2013

Lundell H, Nilsen JB, Ptito M, Dyrby TB, Distribution of collateral fibers in the monkey cervical spinal cord detected with diffusion weighted magnetic resonance imaging, Neuroimage, 2011, 1;56(3):923-9.

Dyrby TB, Baaré WF, Alexander DC, Jelsing J, Garde E, Søgaard LV, An ex vivo imaging pipeline for producing high-quality and high-resolution diffusion weighted imaging datasets, Hum Brain Mapp. 2011;32(4):544-63

Lundell H, Barthelemy D, Skimminge A, Dyrby TB, Biering-Sørensen F, Nielsen JB. Independent spinal cord atrophy measures correlate to motor and sensory deficits in individuals with spinal cord injury. Spinal Cord. 2010

Alexander DC, Hubbard PL, Hall MG, Moore EA, Ptito M, Parker GJ, Dyrby TB. Orientationally invariant indices of axon diameter and density from diffusion MRI Neuroimage. 2010 :1374-89

Dyrby TB, Rostrup E, Baaré WF, van Straaten EC, Barkhof F, Vrenken H, Ropele S, Schmidt R, Erkinjuntti T, Wahlund LO, Pantoni L, Inzitari D, Paulson OB, Hansen LK, Waldemar G; LADIS study group. Segmentation of age-related white matter changes in a clinical multi-center study. Neuroimage, Vol 41, pp. 335-45, 2008 

Dyrby TB, Sogaard LV, Parker GJ, Alexander DC, Lind NM, Baare WF, Hay-Schmidt A, Eriksen N, Pakkenberg B, Paulson OB, Jelsing J., Validation of in vitro probabilistic tractography. Neuroimage, Vol 37, pp. 1267-1277. 2007

Haugbol S, Pinborg LH, Arfan HM, Frokjaer VM, Madsen J, Dyrby TB, Svarer C, Knudsen GM. Reproducibility of 5-HT2A receptor measurements and sample size estimations with [18F]altanserin PET using a bolus/infusion approach. Eur J Nucl Med Mol Imaging, Vol 34, pp. 910-5, 2007

Jelsing J, Hay-Schmidt A, Dyrby T, Hemmingsen R, Uylings HB, Pakkenberg B. The prefrontal cortex in the Gottingen minipig brain defined by neural projection criteria and cytoarchitecture. Brain Res Bull, Vol 70, pp. 322-36, 2006