[EXPIRED] The Capital Region of Copenhagen is looking for A Postdoctoral Research Fellow in Multimodal EEG

3-year postdoctoral research fellow position in multimodal EEG at Danish Research Centre for Magnetic Resonance

We are scaling up our research into brain dynamics using electroencephalography combined with advanced Transcranial Brain Stimulation (TBS) and functional Magnetic Resonance Imaging (fMRI). Our goal is to trace stimulation induced brain dynamics with high temporal and spatial resolution to develop next-generation personalized brain stimulation therapies. More specifically, we conduct state-of-the-art neuroimaging-informed brain stimulation therapy in Parkinson’s disease, Multiple Sclerosis, and Major Depressive Disorder. We are a world leading institution in both informing and reading out brain stimulation effects with EEG and fMRI.

We are looking for an experienced postdoc or research fellow, who:

has extensive experience in EEG research and analysis
enjoys working at the intersection of engineering, neurophysiology, neuroimaging, and clinical neuroscience, and
is eager to advance to the use of EEG in combination with TBS and fMRI

Your role:

You will join a transdisciplinary team focusing on developing and analyzing precision brain stimulation therapy by combining transcranial magnetic stimulation with neuroimaging. You will work in our state-of-the-art brain stimulation laboratories equipped with robotic transcranial brain stimulation, neuronavigation, and EEG

Responsibilities:

Design and conduct EEG-informed precision stimulation experiments
Acquire and analyze data and write up results for publication and dissemination
Contribute to developing precision brain stimulation protocols using MRI and EEG read-outs
Lead the education, methods development, and standardization of EEG research at DRCMR, focusing on developing multimodal TBS-EEG, TBS-MRI, and TBS-EEG-MRI methodologies

Essential skills & experience:

Extensive experience with EEG including strong signal processing skills
A PhD degree in neuroscience, biomedical/electrical engineering, clinical medicine, or related field
A strong publication record in peer-reviewed publications
Team-player with strong written and interpersonal communication skills

Advantageous skills & experience:

Experience with the combination of EEG with TMS and/or MRI.
Experience in teaching and supervision of students and technicians

Working at DRCMR: You will join the Brain Circuit Modulation & Therapy group, led by Hartwig Siebner at the DRCMR (www.drcmr.dk) based at Copenhagen University Hospital Hvidovre. You will have the opportunity to collaborate with engineers, neurologists, psychologists, and interact with other groups at DRCMR.

DRCMR is a leading research center for biomedical MRI in Europe. Approximately 75 researchers from a diverse range of disciplines are currently pursuing basic and clinically applied research. The DRCMR is embedded in the Dept. for Radiology and Nuclear Medicine at the Copenhagen University Hospital Hvidovre, Copenhagen, Denmark. DRCMR has a state-of-the-art MR-research infrastructure enabling translational research, which includes a pre-clinical 7T MR scanner, six whole-body MR scanners (one 7T, four 3T and a 1.5T scanner) and a High-Performance Computer cluster. The DRCMR has pre-clinical labs, a neuropsychology laboratory, an EEG laboratory, and five laboratories for precision brain circuit stimulation. It is situated ~25mins cycle ride from central Copenhagen, a city consistently ranked one of the highest in the world for quality of life [link].

Selected Publications

Siebner, Thomas Hartwig, Stefan Fuglsang, Christopher Fugl Madelung, Annemette Løkkegaard, Flemming Bendtsen, Jens Dahlgaard Hove, Morten Damgaard, Jan Lysgård Madsen, and Hartwig Roman Siebner. “Gastric Emptying Is Not Delayed and Does Not Correlate With Attenuated Postprandial Blood Flow Increase in Medicated Patients With Early Parkinson’s Disease.” Frontiers in Neurology 13 (2022). https://www.frontiersin.org/article/10.3389/fneur.2022.828069.

Madelung, Christopher F., David Meder, Søren A. Fuglsang, Marta M. Marques, Vincent O. Boer, Kristoffer H. Madsen, Esben T. Petersen, Anne-Mette Hejl, Annemette Løkkegaard, and Hartwig R. Siebner. “Locus Coeruleus Shows a Spatial Pattern of Structural Disintegration in Parkinson’s Disease.” Movement Disorders 37, no. 3 (2022): 479–89. https://doi.org/10.1002/mds.28945.

Siebner, Thomas Hartwig, Christopher Fugl Madelung, Flemming Bendtsen, Annemette Løkkegaard, Jens Dahlgaard Hove, and Hartwig Roman Siebner. “Postprandial Increase in Mesenteric Blood Flow Is Attenuated in Parkinson’s Disease: A Dynamic PC-MRI Study.” Journal of Parkinson’s Disease 11, no. 2 (January 1, 2021): 545–57. https://doi.org/10.3233/JPD-202341.

Herz, Damian M., David Meder, Julia A. Camilleri, Simon B. Eickhoff, and Hartwig R. Siebner. “Brain Motor Network Changes in Parkinson’s Disease: Evidence from Meta-Analytic Modeling.” Movement Disorders 36, no. 5 (2021): 1180–90. https://doi.org/10.1002/mds.28468.

Lohse, Allan, David Meder, Silas Nielsen, Anders Elkjær Lund, Damian M Herz, Annemette Løkkegaard, and Hartwig R Siebner. “Low-Frequency Transcranial Stimulation of Pre-Supplementary Motor Area Alleviates Levodopa-Induced Dyskinesia in Parkinson’s Disease: A Randomized Cross-over Trial.” Brain Communications 2, no. 2 (July 1, 2020): fcaa147. https://doi.org/10.1093/braincomms/fcaa147.

Haagensen, Brian N., Damian M. Herz, David Meder, Kristoffer H. Madsen, Annemette Løkkegaard, and Hartwig R. Siebner. “Linking Brain Activity during Sequential Gambling to Impulse Control in Parkinson’s Disease.” NeuroImage: Clinical 27 (January 1, 2020): 102330. https://doi.org/10.1016/j.nicl.2020.102330.

Betts, Matthew J., Evgeniya Kirilina, Maria C. G. Otaduy, Dimo Ivanov, Julio Acosta-Cabronero, Martina F. Callaghan, Christian Lambert, et al. “Locus Coeruleus Imaging as a Biomarker for Noradrenergic Dysfunction in Neurodegenerative Diseases.” Brain 142, no. 9 (September 1, 2019): 2558–71. https://doi.org/10.1093/brain/awz193.

Meder, David, Damian Marc Herz, James Benedict Rowe, Stéphane Lehéricy, and Hartwig Roman Siebner. “The Role of Dopamine in the Brain - Lessons Learned from Parkinson’s Disease.” NeuroImage, Mapping diseased brains, 190 (April 15, 2019): 79–93. https://doi.org/10.1016/j.neuroimage.2018.11.021.

Irmen, Friederike, Andreas Horn, David Meder, Wolf-Julian Neumann, Philip Plettig, Gerd-Helge Schneider, Hartwig Roman Siebner, and Andrea A. Kühn. “Sensorimotor Subthalamic Stimulation Restores Risk-Reward Trade-off in Parkinson’s Disease.” Movement Disorders 34, no. 3 (2019): 366–76. https://doi.org/10.1002/mds.27576.

Meder, David, and Hartwig Roman Siebner. “Spectral Signatures of Neurodegenerative Diseases: How to Decipher Them?” Brain 141, no. 8 (August 1, 2018): 2241–44. https://doi.org/10.1093/brain/awy195.

Lehericy, Stéphane, David E. Vaillancourt, Klaus Seppi, Oury Monchi, Irena Rektorova, Angelo Antonini, Martin J. McKeown, et al. “The Role of High-Field Magnetic Resonance Imaging in Parkinsonian Disorders: Pushing the Boundaries Forward.” Movement Disorders 32, no. 4 (April 1, 2017): 510–25. https://doi.org/10.1002/mds.26968.

Correia, M. M., Rittman, T., Barnes, C. L., Coyle-Gilchrist, I. T., Ghosh, B., Hughes, L. E. & Rowe, J. B.
Towards accurate and unbiased imaging-based differentiation of Parkinson's disease, progressive supranuclear palsy and corticobasal syndrome.
Brain communications. 2, 1, p. 1-18, fcaa051. 2020.

Kaalund, S. S., Passamonti, L., Allinson, K. S. J., Murley, A. G., Robbins, T. W., Spillantini, M. G. & Rowe, J. B.
Locus coeruleus pathology in progressive supranuclear palsy, and its relation to disease severity.
Acta neuropathologica communications. 8, 1, p. 1-11, 11. 2020.

van der Vegt, J. P. M., Hulme, O. J., Madsen, K. H., Buhmann, C., Bloem, B. R., Münchau, A., Helmich, R. C. & Siebner, H. R.
Dopamine agonist treatment increases sensitivity to gamble outcomes in the hippocampus in de novo Parkinson's disease.
NeuroImage. Clinical. 28, p. 1-8, 102362. 2020.

Dogonowski, A. M., Andersen, K. W., Sellebjerg, F., Schreiber, K., Madsen, K. H. & Siebner, H. R.
Functional neuroimaging of recovery from motor conversion disorder: A case report.
NeuroImage. 190, p. 269-274, 2019.

Dubbioso, R., Manganelli, F., Siebner, H. R. & Di Lazzaro, V.
Fast Intracortical Sensory-Motor Integration: A Window Into the Pathophysiology of Parkinson's Disease.
Frontiers in Human Neuroscience. 13, p. 1-14, 111. 2019.

van Eimeren, T., Antonini, A., Berg, D., Bohnen, N., Ceravolo, R., Drzezga, A., Höglinger, G. U., Higuchi, M., Lehericy, S., Lewis, S., Monchi, O., Nestor, P., Ondrus, M., Pavese, N., Peralta, M. C., Piccini, P., Pineda-Pardo, J. Á., Rektorová, I., Rodríguez-Oroz, M., Rominger, A., Seppi, K., Stoessl, A. J., Tessitore, A., Thobois, S., Kaasinen, V., Wenning, G., Siebner, H. R., Strafella, A. P. & Rowe, J. B.
Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System.
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 11, p. 301-309, 2019.

Siebner, Hartwig R., David Meder, and Damian M. Herz. “FMRI in Parkinson’s Disease.” In FMRI: Basics and Clinical Applications, edited by Stephan Ulmer and Olav Jansen, 417–31. Cham: Springer International Publishing, 2020. https://doi.org/10.1007/978-3-030-41874-8_26

Thomsen, B. L. C., Herz, D. M., Siebner, H. R. & Løkkegaard, A.
Dyskinesier ved Parkinsons sygdom: opdatering om nye billeddannende metoder og behandlingsmuligheder.
Ugeskrift for Laeger. 12, 2017, p. 2-6, 2017.

Lehéricy, S., Vaillancourt, D. E., Seppi, K., Monchi, O., Rektorova, I., Antonini, A., McKeown, M. J., Masellis, M., Berg, D., Rowe, J. B., Lewis, S. J. G., Williams-Gray, C. H., Tessitore, A., Siebner, H. R. & International Parkinson and Movement Disorder Society -Neuroimaging Study Group.
The role of high-field magnetic resonance imaging in parkinsonian disorders: Pushing the boundaries forward.
Movement disorders. 32, 4, p. 510-525, 2017.

Løkkegaard A, Herz DM, Haagensen BN, Lorentzen AK, Eickhoff SB, Siebner HR (2016) Altered sensorimotor activation patterns in idiopathic dystonia - an activation likelihood estimation meta-analysis of functional brain imaging studies. Hum Brain Mapp 37:547-557.

Herz DM, Haagensen BN, Nielsen SH, Madsen KH, Løkkegaard A, Siebner HR (2016) Resting-state connectivity predicts levodopa-induced dyskinesias in Parkinson’s disease. Mov Disord 31:521-529.

Herz DM, Haagensen BN, Christensen MS, Madsen KH, Rowe JB, Løkkegaard A, Siebner HR (2015) Abnormal dopaminergic modulation of striato-cortical networks underlies levodopa-induced dyskinesias in humans. Brain 138:1658-1666.

Herz DM, Haagensen BN,Christensen MS, Madsen KH, Rowe J, Løkkegaard A, Siebner HR (2014) The acute brain response to levodopa heralds dyskinesias in Parkinson’s disease. Ann Neurol 75:829-836.

Herz DM, Eickhoff SB, Løkkegaard A, Siebner HR (2014) Functional neuroimaging of motor control in Parkinson’s disease: A meta-analysis. Hum Brain Mapp 35:3227-3237.

van der Vegt JPM, Hulme OJ, Zittel S, Madsen KH, Weiss MM, Buhmann C, Bloem BR, Münchau A, Siebner HR (2013) Attenuated neural response to gamble outcomes in drug-naive patients with Parkinson’s disease. Brain 136:1192-1203.