Melissa Larsen
Tel.
Position
Senior Researcher
Research Interests
I am interested in the brain mechanisms and the connectivity underpinnings of psychotic symptoms and how these develop in the brain. In particular, I am interested in how predictive processes and oscillatory activity are disturbed in psychiatric disorders and further how this relates to brain structure. I am leading the Developmental Psychiatry group where we use a multimodal approach to elucidate the complex relationships between brain, body, cognition, and mental health and how these relationships are modulated by environmental and biological factors. We have a developmental focus since most mental disorders are rooted in abnormal neurodevelopment.
Research Groups
Developmental Psychiatry (Group Leader)
EEG
VIA
TECTO
REFRESH
Curriculum Vitae
Education
2017
PhD in Engineering, Technical University of Denmark, DRCMR, Sankt Hans
2012
MSc in Biomedical Engineering, Technical University of Denmark
2009
BSc in Biomedical Engineering, Technical University of Denmark
Employments
2019 - Present
Postdoc, DRCMR
2017 - 2019
Postdoc, Queensland Brain Institute, University of Queensland, Australia
2017 - 2017
Postdoc, DRCMR
2012 - 2017
PhD Student, DTU Compute and DRCMR
2012 - 2012
Research Assistant, DRCMR
Publications
Full list of publications available at: https://scholar.google.com/citations?user=nTA8W0oAAAAJ
Anna Hester Ver Loren van Themaat, Bob Oranje, Kit Melissa Larsen, Leo Tomasevic, Line Korsgaard Johnsen, Anne Amalie Elgaard Thorup, Kerstin Jessica Plessen, Hartwig Roman Siebner, Merete Nordentoft. Mismatch negativity and P3a amplitude in children with familial high risk of schizophrenia or bipolar disorder - A Danish register-based EEG study. Schizophr Res. 2022 Jul 5;246:187-194. doi: 10.1016/j.schres.2022.06.035.
Oskar Hougaard Jefsen, Yury Shtyrov, Kit Melissa Larsen, Martin J Dietz. The 40-Hz auditory steady-state response in bipolar disorder: A meta-analysis. Clin Neurophysiol. 2022 Jul 6;141:53-61. doi: 10.1016/j.clinph.2022.06.014.
Taylor JA, Larsen KM, Dzafic I, Garrido MI. Predicting subclinical psychotic-like experiences on a continuum using machine learning. Neuroimage. 2021 Jul 22;241:118329. doi: 10.1016/j.neuroimage.2021.118329. Online ahead of print.PMID: 34302968
Taylor JA, Larsen KM, Garrido MI. Multi-dimensional predictions of psychotic symptoms via machine learning. Hum Brain Mapp. 2020 Dec 15;41(18):5151-5163. doi: 10.1002/hbm.25181. Epub 2020 Sep 1.PMID: 32870535.
Larsen KM, Dzafic I, Darke H, Pertile H, Carter O, Sundram S, Garrido MI. Aberrant connectivity in auditory precision encoding in schizophrenia spectrum disorder and across the continuum of psychotic-like experiences. Schizophr Res. 2020 Aug; 222:185-194. doi: 10.1016/j.schres.2020.05.061. Epub 2020 Jun 25.PMID: 32593736.
Johnsen LK, Ver Loren van Themaat AH, Larsen KM, Burton BK, Baaré WFC, Madsen KS, Nordentoft M, Siebner HR, Plessen KJ. Alterations in Task-Related Brain Activation in Children, Adolescents and Young Adults at Familial High-Risk for Schizophrenia or Bipolar Disorder - A Systematic Review. Front Psychiatry. 2020 Jul 10;11:632. doi: 10.3389/fpsyt.2020.00632. eCollection 2020.PMID: 32754058 Free PMC article.
I Dzafic, KM Larsen, H Darke, H Pertile, O Carter, S Sundram, MI Garrido. Stronger Top-Down and Weaker Bottom-Up Frontotemporal Connections During Sensory Learning Are Associated With Severity of Psychotic Phenomena. Schizophrenia Bulletin
Larsen KM, Mørup M, Birknow MR, Fischer E, Olsen L, Didriksen M, Baaré WFC, Werge TM, Garrido MI, Siebner HR. Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds:10.1016/j.nicl.2019.101721. Epub 2019 Feb 13. PubMed PMID: 30785050; PubMed Central PMCID: PMC6383326.
Pellegrino G, Tomasevic L, Herz DM, Larsen KM, Siebner HR. Theta Activity in the Left Dorsal Premotor Cortex During Action Re-Evaluation and Motor Reprogramming. Front Hum Neurosci. 2018 Sep 21;12:364. doi: 10.3389/fnhum.2018.00364. eCollection 2018. PubMed PMID: 30297991; PubMed Central PMCID: PMC6161550.
Larsen KM, Dzafic I, Siebner HR, Garrido MI. Alteration of functional brain architecture in 22q11.2 deletion syndrome - Insights into susceptibility for psychosis. Neuroimage. 2019 Apr 15;190:154-171. doi: 10.1016/j.neuroimage.2018.09.001. Epub 2018 Sep 5. Review. PubMed PMID: 30195053.
Larsen KM, Mørup M, Birknow MR, Fischer E, Hulme O, Vangkilde A, Schmock H, Baaré WFC, Didriksen M, Olsen L, Werge T, Siebner HR, Garrido MI. Altered auditory processing and effective connectivity in 22q11.2 deletion syndrome. Schizophr Res. 2018 Jul;197:328-336. doi: 10.1016/j.schres.2018.01.026. Epub 2018 Feb 1. PubMed PMID: 29395612.
Larsen KM, Pellegrino G, Birknow MR, Kjær TN, Baaré WFC, Didriksen M, Olsen L, Werge T, Mørup M, Siebner HR. 22q11.2 Deletion Syndrome Is Associated With Impaired Auditory Steady-State Gamma Response. Schizophr Bull. 2018 Feb 15;44(2):388-397. doi: 10.1093/schbul/sbx058. PubMed PMID: 28521049; PubMed Central PMCID: PMC5815132.
Schmock H, Vangkilde A, Larsen KM, Fischer E, Birknow MR, Jepsen JR, Olesen C, Skovby F, Plessen KJ, Mørup M, Hulme O, Baaré WF, Didriksen M, Siebner HR, Werge T, Olsen L. The Danish 22q11 research initiative. BMC Psychiatry. 2015 Sep 17;15:220. doi: 10.1186/s12888-015-0594-7. PubMed PMID: 26384214; PubMed Central PMCID: PMC4574168.