DRCMR Logo 300px Color
 
Mattias Rickhag

Email

Tel.

Position

Assistant Professor

Affiliations

Molecular Neuropharmacology Laboratory, Department of Neuroscience, University of Copenhagen

Research Interests

I have a genuine research background in experimental animal models of neurodegenerative diseases. I wish to bridge molecular and system neuroscience and investigate aberrant circuit adaptations in models of Parkinson’s disease (PD). I will combine a chemogenetic platform and lesion models with neuroimaging to capture network changes and use pathway-selective manipulations of BG cell populations to restore motor function in rodent models of PD. In parallel, G-protein coupled receptor (GPCR) mapping/functional analysis in key target BG cell populations (striatal projection neurons) is performed to identify putative novel non-dopaminergic targets for PD pharmacotherapy

Research Groups

Preclinical Research group

Curriculum Vitae

Education

2007

PhD in Experimental Brain Research, Medical Faculty, Lund University

2002

MSc in Biomedicine, Lund University

Employments

2015 - Present

Assistant Professor, Department of Neuroscience, University of Copenhagen

2011 - 2015

Post-doctoral fellow (grant from the Lundbeck Foundation), Department fo Neuroscience, University of Copenhagen

2008 - 2010

Post-doctoral fellow (grant from the Danish Research Council), Department of Neuroscience, University of Copenhagen

2003 - 2007

PhD Student, Medical Faculty, Lund University, Sweden

Full CV

Publications

1. Ciriachi C, Svane-Petersen D and Rickhag M (2019). Genetic Tools to Study Complexity of Striatal Function. Journal of Neuroscience Research. 2019 Oct;97(10):1181-1193.

2. DiCarlo GE, Aguilar JI, Matthies HJ, Harrison FE, Bundschuh KE, West A, Hashemi P, Herborg F, Rickhag M, Chen H, Gether U, Wallace MT, Galli A (2019). Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors.  Journal of Clinical Investigation. 2019 May 16;129(8):3407-3419.

3. Bay Kønig A, Ciriachi C, Gether U and Rickhag M (2019). Chemogenetic Targeting of Dorsomedial Direct-Pathway Striatal Projection Neurons Selectively Elicits Rotational Behavior in Mice. Neuroscience. 2019 Mar 1; 401:106-116.

4. Runegaard A, Sørensen AT, Fitzpatrick C, Jørgensen S, Petersen A, Hansen N, Weikop P, Andreasen J, Mikkelsen J, Perrier JF, Woldbye D, Rickhag M, Wörtwein G and Gether U (2018). Locomotor- and reward-enhancing effects of cocaine are differentially regulated by chemogenetic stimulation of Gi-signaling in dopaminergic neurons. eNeuro: 0345-17.2018 

5. Jensen K, Sørensen G, Dencker D, Owens W, Rahbek-Clemmensen T, Brett Lever M, Runegaard A, Riis Christensen N, Weikop P, Wörtwein G, Fink-Jensen A, Madsen K, Daws L, Gether U and Rickhag M. (2018). PICK1-deficient mice exhibit impaired response to cocaine and dysregulated dopamine homeostasis. eNeuro:0422-17.2018

6. Jensen KL, Runegaard AH, Weikop P, Gether U and Rickhag M (2017). Assessment of Dopaminergic Homeostasis in Mice by Use of High-Performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake. Journal of Visualized Experiments, 127, e56093, doi:10.3791/56093

7. Runegaard AH, Jensen KL, Fitzpatrick CM, Dencker D, Weikop P, Gether U and Rickhag M (2017). Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice. European Journal of Neuroscience, 45(1):121-128

8. Apuschkin M, Stilling S, Rahbek-Clemmensen T, Sørensen G, Fortin G, Herborg Hansen F, Eriksen J, Trudeau LE, Egerod K, Gether U and Rickhag M (2015). A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity. European Journal of Neuroscience 42: 2438-2454

9. Steinkellner T, Montgomery TR, Hofmaier T, Kudlacek O, Yang JW, Rickhag M, Jung G, Lubec G, Gether U, Freissmuth M, Sitte HH (2015). Amphetamine action at the cocaine- and antidepressant sensitive serotonin transporter is modulated by αCaMKII. Journal of Neuroscience 27;35(21):8258-71

10. Steinkellner T, Mus L, Eisenrauch B, Constantinescu A, Leo D, Konrad L, Rickhag M, Sørensen G, Efimova EV, Kong E, Willeit M, Sotnikova TD, Kudlacek O, Gether U, Freissmuth M, Pollak DD, Gainetdinov RR, Sitte HH (2014). In vivo amphetamine action is contingent on -CaMKII. Neuropsychopharmacology 39(11): 2681-93

11. Rickhag M, Owens WA, Winkler MT, Strandfelt KN, Rathje M, Andresen B, Sørensen G, Madsen KL, Jørgensen TN, Wörtwein G, Woldbye DP, Sitte H, Daws LC and Gether U (2013).  Membrane permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release. Journal of Biological Chemistry 20;288(38): 27534-44

12. Rickhag M, Hansen FH, Sørensen G, Strandfelt KN, Andresen B, Gotfryd K, Madsen KL, Vestergaard-Klewe I, Ammendrup-Johnsen I, Eriksen J, Newman AH, Füchtbauer EM, Gomeza J, Woldbye DP, Wörtwein G and Gether U (2013). A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter. Nature Communications 4:1580;

13. Holst B, Madsen KL, Jansen AM, Jin C, Rickhag M, Lund VK, Jensen M, Bhatia V, Sørensen G, Madsen AN, Xue Z, Møller SK, Woldbye DP, Qvortrup K, Huganir R, Stamou D, Kjærulff O and Gether U. (2013). PICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose Tolerance. PLoS Biology 11(4):e1001542

14. Ruscher K, Shamloo M, Rickhag M, Ladunga I, Soriano L, Gisselsson L, Toresson H, Ruslim-Litrus L, Oksenberg D, Urfer R, Johansson BB, Nikolich K and Wieloch T  (2011). The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke. Brain 134(3): 732-46

15. Ruscher K, Johannesson E, Brugiere E, Erickson A, Rickhag M and Wieloch T (2009). Enriched enviroment reduces apolipoprotein E (ApoE) in reactive astrocytes and attenuates inflammation of the peri-infarct tissue after experimental stroke. Journal of Cerebral Blood Flow and Metabolism 29(11): 1796-805

16. Rickhag M, Deierborg T, Patel S, Ruscher K and Wieloch T (2008). Apolipoprotein D is elevated in oligodendrocytes in the peri-infarct region after experimental stroke – Influence of enriched environment. Journal of Cerebral Blood Flow and Metabolism 28(3): 551-62

17. Rickhag M, Teilum M and Wieloch T (2007). Rapid and long-term induction of effector immediate-early genes (BDNF, Neuritin and Arc) in peri-infarct cortex and dentate gyrus after ischemic injury in rat brain. Brain Research. 1151: 203-210

18. Shamloo M, Soriano L, von Schack D, Rickhag M, Chin DJ, Gonzalez-Zulueta M, Gido G, Urfer R, Wieloch T and Nikolich K (2006). Npas4, a novel helix-loop-helix PAS domain protein, is regulated in response to cerebral ischemia. European Journal of Neuroscience. 24(10): 2705-2720

19. Takao K, Rickhag M, Hegardt C, Oredsson S and Persson L (2006). Induction of apoptotic cell death by putrescine. Int J Biochem Cell Biol. 38(4): 621-8

20. Rickhag M, Wieloch T, Gidö G, Elmer E, Krogh M, Murray J, Lohr S, Bitter H, Chin DJ, von Schack D, Shamloo M and Nikolich K (2006). Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia-induced gene expression patterns, and reveals a biphasic activation of genes in surviving tissue. Journal of Neurochemistry. 96(1): 14-29

21. Urfer R, Rickhag M, Oksenberg D, Shamloo M, Lohr S, Murray J, Krogh M, Johansson B, Nikolich K, Wieloch T (2005). A new approach to enhancement of functional recovery after stroke by genomics analysis of the enriched environment model. Stroke. 36(2): 427-428