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Kathrine Skak Madsen



+45 3862 3323


Senior Researcher, Senior Associate Professor


University College Copenhagen

Research Interests

My research is mainly within the fields of developmental cognitive neuroscience, developmental psychiatry, and pediatric neuroimaging. My research focuses on individual differences in human brain and behavioral development, and on how environmental and hormonal factors modulate such development. I am particularly interested in characterizing typical and atypical brain and behavioral developmental trajectories and in mapping developing brain-behavioral relationships. In my research, I employ multimodal neuroimaging techniques, behavioral and clinical assessments, and sampling of biomarkers in cross-sectional and longitudinal studies of typically developing and at-risk pediatric populations.

Curriculum Vitae



Higher Educational Teaching, University of Copenhagen, Denmark


PhD in Neuroscience, DRCMR & Cimbi, Faculty of Health Sciences, University of Copenhagen, Denmark


MSc in (Neuro)biology, University of Copenhagen, Denmark


2015 - Present

Senior Researcher, DRCMR

2016 - 2023

Senior Associate Professor (Docent), University College Copenhagen

2011 - 2015

Cimbi work package leader: Brain maturation, DRCMR & Cimbi

2011 - 2014

Postdoc, DRCMR & Cimbi

2008 - 2011

PhD Student, DRCMR & Cimbi

2006 - 2008

Research Assistant, DRCMR & Cimbi

2004 - 2006

Research Volunteer and member of the Unit of Cognitive Neuroscience, Department of Psychology, University of Copenhagen


Video Pitch: Presentation

Larsen KM, Madsen KS, Ver Loren van Themaat AH, Thorup AAE, Plessen KJ, Nordentoft M, Siebner HR (2024) Children at familial high risk of schizophrenia and bipolar disorder exhibit altered connectivity patterns during pre-attentive processing of an auditory prediction error. Schizophrenia Bulletin 50(1): 230. https://doi.org/10.1093/schbul/sbad092

Fjell AM, Sørensen Ø, Wang Y, Amlien IK, Baaré WFC, Bartrés-Faz D, Bertram L, Boraxbekk CJ, Brandmaier AM, Demuth I, Drevon CA, Ebmeier KP, Ghisletta P, Kievit R, Kühn S, Madsen KS, Mowinckel AM, Nyberg L, Sexton CE, Solé-Padullés C, Vidal-Piñeiro D, Wagner G, Watne LO, Walhovd KB (2023) No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy. Nature Human Behavior 7:2008-2022. https://doi.org/10.1038/s41562-023-01707-5

Plachti A, Latzman RD, Maleki S, Hoffstaedter F, Skak Madsen K, Baare W, Siebner HR, Eickhoff SB, Genon S (2023) Progress in Neurobiology Hippocampal anterior- posterior shift in childhood and adolescence. Progress in Neurobiology 225:102447. https://doi.org/10.1016/j.pneurobio.2023.102447

Plachti A, Baaré WFC, Johansen LB, Thompson WK, Siebner HR, Madsen KS (2023) Stability of associations between neuroticism and microstructural asymmetry of the cingulum during late childhood and adolescence: Insights from a longitudinal study with up to 11 waves. Human Brain Mapping 44:1548–1564. https://doi.org/10.1002/hbm.26157

Fuhrman D*, Madsen KS*, Johansen LB, Baaré WFC, Kievit RA (2022) The midpoint of cortical thinning between late childhood and early adulthood differs across individuals and regions: Evidence from longitudinal modelling in a 12-wave sample. Neuroimage 261, 119507. https://doi.org/10.1016/j.neuroimage.2022.119507

Thorup AAE, Hemager N, Bliksted VF, Greve AN, Ohland J, Wilms M, Rohd SB, Merete Birk, Bundgaard AF, Laursen AF, Jefsen OH, Steffensen NL, Andreassen AK, Veddum L, Knudsen CB, Enevoldsen M, Nymand M, Brandt JM, Søndergaard A, Carmichael L, Gregersen M, Falkenberg MK, Burton HBK, Dietz D, Nudel R, Johnsen LK, Larsen KM, Meder D, Hulme OJ, Barré WFC, Madsen KS, Lund TE, Østergaard L, Juul A, Kjær T, Hjorthøj C, Siebner HR, Mors O, Nordentoft M (2022) The Danish High Risk and Resilience Study – VIA 15 – a study protocol for the third clinical assessment of a cohort of 522 children born to parents diagnosed with schizophrenia, bipolar disorder or none of these disorders. Frontiers in Psychiatry 13, 809807. https://doi.org/10.3389/fpsyt.2022.809807

Marybel Robledo Gonzalez , William F.C. Baaré, Donald J. Hagler Jr., Sarah Archibald, Martin Vestergaard, Kathrine Skak Madsen. Brain structure associations with phonemic and semantic fluency in typically-developing children. Developmental Cognitive Neuroscience. 2021. https://doi.org/10.1016/j.dcn.2021.100982

Vestergaard M, Baaré WFC, Holm SK, Madsen CG, Paulson OB, Born AP, Uldall P, Siebner HR, Madsen KS (2021) Glucocorticoid treatment for non-cerebral diseases in children and adolescents is associated with differences in uncinate fasciculus microstructure. Pediatric Research

Budin-Ljøsne I, Friedman BB, Suri S, Solé-Padullés C, Düzel S, Drevon CA, Baaré WFC, Mowinckel AM, Zsoldos E, Madsen KS, Carver RB, Ghisletta P, Arnesen MR, Faz DB, Brandmaier AM, Fjell AM, Kvalbein A, Henson RN, Kievit RA, Nawijn L, Pochet R, Schnitzler A, Walhovd KB, Zasiekina L (2020). The Global Brain Health Survey: Development of a Multi-Language Survey of Public Views on Brain Health. Frontiers in Public Health. DOI:10.3389/fpubh.2020.00387.

Johnsen LK, Ver Loren van Themaat AH, Larsen KM, Burton BK, Baaré WFC, Madsen KS, Nordentoft M, Siebner HR, Plessen KJ (2020). Alterations in Task-Related Brain Activation in Children, Adolescents and Young Adults at Familial High-Risk for Schizophrenia or Bipolar Disorder - A Systematic Review. Frontiers in Psychiatry. DOI:10.3389/fpsyt.2020.00632.

Madsen KS, Johansen LB, Thompson WK, Siebner HS, Jernigan TL, Baaré WFC (2020). Maturational trajectories of white matter microstructure underlying the right presupplementary motor area reflect individual improvements in motor response cancellation in children and adolescents. Neuroimage 220: 117105. DOI: 10.1016/j.neuroimage.2020.117105

Bachmann R, Ingebrigtsen RL, Madsen KS, Holm O, Christensen AF, Lauridsen CA (2020). CO-score; a new method for quality assessment of radiology reports. Radiography 26(3): E152-E157. DOI: 10.1016/j.radi.2020.01.003.

Bauer C, Dyrby TB, Sellebjerg F, Madsen KS, Svolgaard O, Blinkenberg M, Siebner HR, Andersen KW (2020). Motor fatigue is associated with asymmetric connectivity properties of the corticospinal tract in multiple sclerosis. Neuroimage: Clinical 28: 102393. DOI:10.1016/j.nicl.2020.102393.

Friedman, B. B., Suri, S., Solé-Padullés, C., Düzel, S., Drevon, C. A., Baaré, W. F. C., Bartrés-Faz, D., Fjell, A. M., Johansen-Berg, H., Madsen, K. S., Nyberg, L., Penninx, B. W. J. H., Sexton, C., Walhovd, K. B., Zsoldos, E. & Budin-Ljøsne, I. Are People Ready for Personalized Brain Health? Perspectives of Research Participants in the Lifebrain Consortium. The Gerontologist.
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Holm, K.S., Madsen, K.S., Vestergaard, M., Born, A.P., Paulson, O.B., Siebner, H.R., Uldall, P., Baaré, W.F.C. Previous glucocorticoid treatment in childhood and adolescence is associated with long-term differences in subcortical grey matter volume and microstructure. Neuroimage Clinical. 2019. https://www.ncbi.nlm.nih.gov/pubmed/31004915

Madsen, K.S., Jernigan, T.J., Vestergaard, M., Mortensen, E.L., Baaré, W.F.C. Neuroticism is linked to microstructural left-right asymmetry of fronts-limbic fibre tracts in adolescents with opposite effects in boys and girls. Neuropsychologia. 2018. https://www.ncbi.nlm.nih.gov/pubmed/29654882

Holm, S. K., Madsen, K. S., Vestergaard, M., Paulson, O. B., Uldall, P., Siebner, H. R., Born, A. P. & Baaré, W. F. C.
Total brain, cortical and white matter volumes in children previously treated with glucocorticoids. Pediatric Research. 2018.

Holm-Skjold, J., Baaré, W. F. C., Mogensen, J., Siebner, H. R., Jernigan, T. L. & Madsen, K. S.
Development of emotional processing is linked to maturational changes in left-right cingulum asymmetry during adolescence. 1 p., 2017.

Ekstrand, A. S., Baaré, W. F. C., Holm-Skjold, J., Siebner, H. R., Jernigan, T. L. & Madsen, K. S.
Maturation of major white matter tracts during childhood and adolescence: A longitudinal study with up to 11 time points. 1 p., 2017.

Baruël Johansen, L., Madsen, K. S., Andersen, K. W., Madsen, K. H., Siebner, H. R. & Baaré, W. F. C.
Reduced orbitofrontal functional network centrality characterizes high neuroticism across childhood and adolescence. 2017.

Vestergaard, M., Krøis Holm, S., Uldall, P., Siebner, H. R., Paulson, O. B., Baaré, W. F. C. & Madsen, K. S.
Glucocorticoid treatment earlier in childhood and adolescence show dose-response associations with diurnal cortisol levels. Developmental Psychobiology. 59, 8, p. 1010-1020, 2017.

Hjordt, L. V., Stenbæk, D. S., Madsen, K. S., Mc Mahon, B., Jensen, C. G., Vestergaard, M., Hageman, I., Meder, D., Hasselbalch, S. G. & Knudsen, G. M.
State-dependent alterations in inhibitory control and emotional face identification in seasonal affective disorder. Journal of Abnormal Child Psychology. 126, 3, p. 291-300, 2017.

Madsen, K. S., Jernigan, T. L., Reuter, C., Thompson, W. K. & Baaré, W. F. C. Developing consistency in reaction time associated with stable individual differences in motor system microstructure: A longitudinal DTI study of children and adolescents. 2016.

Bauer, C., Andersen, K. W., Svolgaard, O. M. R., Sellebjerg, F. T., Madsen, K. S., Madsen, K. H., Dyrby, T. B. & Siebner, H. R. Microstructural white matter correlates of motor fatigue in multiple sclerosis: a diffusion weighted imaging study. 2016.

Baruël Johansen, L., Madsen, K. S., Andersen, K. W., Madsen, K. H., Siebner, H. R. & Baaré, W. F. C. Reduced global efficiency and orbitofrontal centrality of the functional brain network characterizes high neuroticism in adolescence. 2016.

Angstman S, Madsen KS, Skimminge A, Jernigan TL, Baaré WF, Siebner HR. Microstructural asymmetry of the corticospinal tracts predict right-left differences in circle drawing skill in right-handed adolescents. Brain Structure and Function, 2016, Epub ahead of print. 

Knudsen GM, Jensen PS, Erritzoe D, Baaré WF, Ettrup A, Fisher PM, Gillings N, Hansen HD, Hansen LK, Hasselbalch SG, Henningson S, Herth MM, Holst KK, Iversen P, Kessing LV, Macoveanu J, Madsen KS, Mortensen EL, Nielsen FÅ, Paulson OB, Siebner HR, Stenbæk DS, Svarer C, Jernigan TL, Strother SC, Frokjaer VG. The Center for Integrated Molecular Brain Imaging (Cimbi) Database. Neuroimage, 2016, 124(Pt B): 1213-19.

Madsen KS. Evaluation of continuous formative assessment during lectures. In Improving University Science Teaching and Learning: Pedagogical Projects 2015, vol 8, no. 1-2, chap. 22, pp. 261-274.

Holm SK, Vestergaard M, Madsen KS, Baaré WF, Hammer TB, Born AP, Siebner HR, Paulson OB, Uldall PV. Children and adolescents previously treated with glucocorticoids display lower verbal intellectual abilities. Acta Paediatrica, 2015, 104(8): 784-91.

Frokjaer VG, Erritzoe D, Holst KK, Madsen KS, Fisher PM, Madsen J, Svarer C, Knudsen GM. In abstinent MDMA users the cortisol awakening response is off-set bur associated with prefrontal serotonin transporter binding as in non-users. International Journal of Neuropsychopharmacology, 2014, 17(8): 1119-28.

Aarnink SH, Vos SB, Leemans A, Jernigan TL, Madsen KS, Baaré WFC. Automated Longitudinal Intra-Subject Analysis (ALISA) for diffusion MRI tractography. Neuroimage, 2014, 86:404-416.

Klarborg B*; Madsen KS*; Vestergaard M; Skimminge A; Jernigan TL; Baaré WFC. Sustained attention is associated with right superior longitudinal fasciculus and superior parietal white matter microstructure in children. Human Brain Mapping, 2013, 34(12): 3216-32.

Barüel Johansen L; Siebner HR; Werge T; Madsen KS. Hjernen - genetik og udvikling i billeder. In Hjerneforum's book: Den genetiske hjerne. Tommerup N. (Ed.) 2013, chap. 4, pp. 23-6.

Frokjaer VG; Erritzoe; Holst KK; Jensen PS; Rasmussen PM; Fisher PM; Baaré W; Madsen KS; Madsen J; Svarer C; Knudsen GM. Prefrontal serotonin transporter availability is positively associated with the cortisol awakening response. European Neuropsychopharmacology, 2013, 23(4): 285-94.

Madsen KS; Jernigan TL; Iversen P; Frokjaer VG; Knudsen GM; Siebner HR; Baare WF. Hypothalamic-pituitary-adrenal axis tonus is associated with hippocampal microstructural asymmetry. Neuroimage, 2012, 63(1): 95-103.

Madsen KS; Jernigan TL; Iversen P; Frokjaer VG; Mortensen EL; Knudsen GM; Baare WF. Cortisol awakening response and negative emotionality linked to asymmetry in major limbic fibre bundle architecture. Psychiatry Research: Neuroimaging, 2012, 201(1): 63-72.

Madsen KS; Baaré WF; Skimminge A; Vestergaard M; Siebner HR; Jernigan TL. Brain microstructural correlates of visuospatial choice reaction time in children. Neuroimage, 2011, 58(4): 1090-1100.

Jernigan TL; Baare WF; Stiles J; Madsen KS. Postnatal brain development: Structural imaging of dynamic neurodevelopmental processes. Progress in Brain Research 2011, 189: 77-92.

Vestergaard M*; Madsen KS*; Baare WF; Skimminge A; Ejersbo LR; Ramsoy TZ; Gerlach C; Akeson P; Paulson OB; Jernigan TL. White matter microstructure in superior longitudinal fasciculus associated with spatial working memory performance in children. Journal of Cognitive Neuroscience, 2011, 23(9): 2135-2146.

Madsen KS; Baare WF; Vestergaard M; Skimminge A; Ejersbo LR; Ramsoy TZ; Gerlach C; Akeson P; Paulson OB; Jernigan TL. Response inhibition is associated with white matter microstructure in children. Neuropsychologia, 2010, 48(4): 854-862.

Madsen KS; Holm DA; Sogaard LV; Rowland IJ. Effect of paramagnetic manganese cations on (1)H MRS of the brain. NMR in Biomedicine, 2008, 21(10): 1087-1093.

Mala H; Alsina CG; Madsen KS; Sibbesen EC; Stick H; Mogensen J. Erythropoietin improves place learning in an 8-arm radial maze in fimbria-fornix transected rats. Neural Plasticity, 2005, 12: 329-340.