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BaSiCs (Biophysically adjusted State-informed Cortex stimulation) is a collaboration with the Danish Technical University (DTU) and is supported by a synergy grant from Novo Nordisk Foundation (2015-2018).

  • Funded by: Novo Nordisk Foundation
  • Grant Size: 15.000.000 Kr.


Non-invasive transcranial brain stimulation (NTBS) is used to restore brain function after injury, treat psychiatric disorders, and to boost normal cognitive abilities. The basic mechanisms of NTBS are still poorly understood and people show highly variable responses to NTBS. Trait-related and state-related determinants contribute to this variability.
The BaSiCs project aims at increasing the efficacy of NIBS by adjusting stimulation parameters to individual anatomical and functional differences using 

Our interdisciplinary team pursues two lines of research:

(i) Biophysically adjusted NTBS: We perform advanced modelling of the electrical fields that are induced by NTBS in individual brains. We use this information to adjust intensity and spatial arrangement of NTBS to optimally target the cortical network of interest. 

(ii) State-informed NTBS: We use electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) to identify the spatiotemporal signatures of functional and dysfunctional brain states at an individual level. EEG and fMRI also enable us to trace the dynamic expression of these “state signatures” during NTBS. We use this information to adapt NTBS to these signatures in the healthy and diseased human brain.


The BaSiCs group exploits functional brain mapping, electrical field modelling, and machine learning to push the frontiers of Non-invasive
Transcranial Brain Stimulation (NTBS) as interventional tool to improve the function of human brain networks


Associated Publications

Thut, G., Bergmann, T. O., Fröhlich, F., Soekadar, S. R., Brittain, J-S., Valero-Cabré, A., Sack, A., Miniussi, C., Antal, A., Siebner, H. R., Ziemann, U. & Herrmann, C. S. Guiding transcranial brain stimulation by EEG/MEG to interact with ongoing brain activity and associated functions: A position paper. Clinical neurophysiology. 128, 5, p. 843-857, 2017.

Tia, B., Takemi, M., Kosugi, A., Castagnola, E., Ansaldo, A., Nakamura, T., Ricci, D., Ushiba, J., Fadiga, L. & Iriki, A. Cortical control of object-specific grasp relies on adjustments of both activity and effective connectivity: a common marmoset study. The Journal of physiology. 595, 23, p. 7203-7221, 2017.

Antal, A., Alekseichuk, I., Bikson, M., Brockmöller, J., Brunoni, A. R., Chen, R., Cohen, L. G., Dowthwaite, G., Ellrich, J., Flöel, A., Fregni, F., George, M. S., Hamilton, R., Haueisen, J., Herrmann, C. S., Hummel, F. C., Lefaucheur, J-P., Liebetanz, D., Loo, C. K., McCaig, C. D., Miniussi, C., Miranda, P. C., Moliadze, V., Nitsche, M. A., Nowak, R., Padberg, F., Pascual-Leone, A., Poppendieck, W., Priori, A., Rossi, S., Rossini, P. M., Rothwell, J. C., Rueger, M. A., Ruffini, G., Schellhorn, K., Siebner, H. R., Ugawa, Y., Wexler, A., Ziemann, U., Hallett, M. & Paulus, W. Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines. Clinical neurophysiology. 128, 9, p. 1774-1809, 2017.

Karabanov A, Thielscher A, Siebner H: Transcranial brain stimulation: closing the loop between brain and stimulation. Current Opinion in Neurobiology 2016, EPUB ahead of print

Bergmann TO, Karabanov A, Hartwigsen G, Thielscher A, Siebner HR: Combining non-invasive transcranial brain stimulation with neuroimaging and electrophysiology: Current approaches and future perspectives. Neuroimage 2016. Epub ahead of print.

Hartwigsen G, Bergmann TO, Herz DM, Angstmann S, Karabanov A, Raffin E, Thielscher A, Siebner HS:  Modeling the effects of noninvasive transcranial brain stimulation at the biophysical, network, and cognitive LevelProgress in Brain Research 2015; 222, 261-287. 

Raffin E, Pellegrino G, Di Lazzaro V, Thielscher A, Siebner HR: Bringing transcranial mapping into shape: Sulcus-aligned mapping captures motor somatotopy in human primary motor hand area. Neuroimage. 2015;120:164-75

Project Leader


Hartwig Siebner   Hartwig R. Siebner



DRCMR Members

Kristoffer Hougaard Madsen

Axel Thielscher

Co-Project Leader

Oula Puonti

Leo Tomasevic

Show all group members (5)

External Members


Lars Kai Hansen

Prof. Lars-Kai Hansen

Department of Applied Mathematics and Computer Science, DTU Compute