Acquisition Technology

 Some of the activities in the Acquisition Technology group involves development of hardware. The image shows unique electronics developed by Christian G. Hanson for real-time processing of signals acquired during MRI. This was used in the Ph.D. project of Jan Ole Petersen focused on combining MR and non-MR data (collaboration with Dr. Rong Xue, Institute of Biophysics, Chinese Academy of Sciences).

Focus areas: 

  • Motion and artifacts
  • Multi-modal data acquisition 
  • Spectroscopy and spectroscopic imaging
  • Fundamentals and education

The members of the Acquisition Technology at the DRCMR and DTU do research improving MR scanning, e.g. with respect to speed, robustness, sensitivity or specificity. They also work on separate topics in other research groups. The employed methods range from fundamental physics to advanced data processing techniques needed to extract important physiological parameters from the measurements. The targets of the development include imaging, spectroscopy, and multi-modal acquisition, e.g. for muscle and brain studies. This benefits, for example, the departments highfield research, and studies of multiple sclerosis and aging. 

The group also contributes to research projects, e.g., concerning sequence choices and sensitivity consideration, and provide education in MRI physics and techniques at the DRCMR, the DTU and elsewhere. Educational material and software is made freely available, and is used widely internationally.

Associated Publications

Göksu, C., Hanson, L. G., Siebner, H. R., Ehses, P., Scheffler, K. & Thielscher, A. Human in-vivo brain magnetic resonance current density imaging (MRCDI). NeuroImage. 171, p. 26-39, 2018.

Göksu C, Scheffler K, Ehses P, Hanson L.G, Thielscher A. Sensitivity Analysis of Magnetic Field Measurements for Magnetic Resonance Electrical Impedance Tomography (MREIT), Magnetic Resonance in Medicine. 79, p. 748-760, 2018.

Pedersen J.O., Hanson C.G., Xue R., and Hanson L.G., Encoding of Inductively Measured k-Space Trajectories in MR Raw Data. Proc. of the 25th annual meeting of the ISMRM, 3906, 2017

Pedersen J.O., Hanson C.G., Xue R., and Hanson L.G., Mary had a little Lamb: Scanner-recorded speech during MRI without gradient-induced sound. Oral pitch, Proc. of the 25th annual meeting of the ISMRM, 765, 2017 

Magnusson  P.O., Boer V.O., Marsman A., Hanson L.G., Petersen E.T., GABA-edited echo-planar spectroscopic imaging (EPSI) with MEGA-sLASER at 7T. Oral presentation, Proc. of the 25th annual meeting of the ISMRM, 1255, 2017

Eldirdiri A., Posse S., Hanson L.G, Hansen R.B., Hansen A.E., Ardenkjær-Larsen J.H.,  Echo Planar Spectroscopic Imaging of Hyperpolarized 13C in a Clinical System with Reduced Chemical Shift Artifacts. Proc. of the 25th annual meeting of the ISMRM, 3691, 2017

Göksu C., Hanson L.G., Ehses P., Scheffler K., and Thielscher A., Human In-vivo MR Current Density Imaging (MRCDI) Based on Optimized Multi-echo Spin Echo (MESE). Proc. of the 25th annual meeting of the ISMRM, 4039, 2017

Hanson L.G., Day 1 of MRI and NMR education: Interactive visualization of MR basics. Proc. of the 25th annual meeting of the ISMRM, 3818, 2017

Hanson L.G., Bloch simulation and MR fundamentals visualized, Invited oral presentation. Proc. of Magnetic Moments in Central Europe, 46, 2017

Andersen, M., Hanson, L. G., Madsen, K. H., Wezel, J., Boer, V., van der Velden, T., van Osch, M. J. P., Klomp, D., Webb, A. G. & Versluis, M. J. Measuring motion-induced B0 -fluctuations in the brain using field probes. Magnetic Resonance in Medicine, 75(5):2020-30, 2016.

Andersen, M., Towards Motion-Insensitive Magnetic Resonance Imaging Using Dynamic Field Measurements. PhD thesis, Technical University of Denmark, Electrical Engineering. 109 p., 2016.

Jørgensen, A., Magnusson, P., Hanson, L. G., Kirkegaard, T., Benveniste, H., Lee, H., Svarer, C., Mikkelsen, J. D., Fink-Jensen, A., Knudsen, G. M., Paulson, O. B., Bolwig, T. G. & Jorgensen, M. B. Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression. Acta Psychiatrica Scandinavica. 133, p. 154-164, 2016.

Andersen, M, Madsen, K. H. and Hanson, L. G., Prospective motion correction for MRI using EEG-equipment, Proc. of the 24th ISMRM conference, 4254, 2016.

P. Magnusson, P. R. Jensen, T. Dyrby, M. Karlsson, M. H. Lerche and L. G. Hanson, SingleShot-RARE for rapid 3D hyperpolarized metabolic ex vivo tissue imaging: RF-pulse design for semi-dense spectra. Proc. of the ESMRMB 33th Annual Meeting, 322, 2016.

C. Göksu, L. G. Hanson, P. Ehses, K. Scheffler, and A. Thielscher, Efficiency Analysis of Magnetic Field Measurement for MR Electrical Impedance Tomography (MREIT). Proc. of the ESMRMB 33th Annual Meeting, 162, 2016.

L. G. Hanson, Educational simulator app and web page for exploring Nuclear and Compass Magnetic Resonance. Proc. of the ESMRMB 33th Annual Meeting. 534, 2016.

Magnusson, P.O, Jensen, P.R, Dyrby, T.B., Karlsson, M., Lerche, M.H. and L.G. Hanson. 3D Metabolic ex vivo sample imaging of hyperpolarized compounds using a 3D Single-Shot RARE (3D SS-RARE) sequence, combining spectral RF selectivity with undersampled spectral encoding at signal read-out. Proceedings of the 5th International DNP Symposium, 2015.

Hanson, L. G. The Ups and Downs of Classical and Quantum Formulations of Magnetic Resonance. Book chapter in Anthropic Awareness: The Human Aspects of Scientific Thinking in NMR Spectroscopy and Mass Spectrometry. Edited by: C Szantay, Jr. Elsevier, Chap. 3, p. 141-171, 2015.

Andersen, M., Madsen, K. H., Hanson, L. G., Boer, V., van der Velden, T., Klomp, D., Wezel, J., Osch, M. J. V., Webb, A. G. & Versluis, M. J. Placement of field probes for stabilization of breathing-induced B0-fluctuations in the brain. Proceedings of the ISMRM conference, p. 1015, 2015.

Andersen M, Madsen KH, Hanson LG, Boer V, van der Velden T, Klomp D, Wezel J, van Osch M, Versluis MJ. Mapping and correcting respiration-induced field changes in the brain using fluorine field probes. Proceedings of the ISMRM/ESMRMB conference, 2014.

Lund, H., Krakauer, M., Skimminge, A., Sellebjerg, F., Garde, E., Siebner, H. R., Paulson, O. B., Hesse, D. & Hanson, L. G. Blood-brain barrier permeability of normal appearing white matter in relapsing-remitting multiple sclerosis. P L o S One. 8, 2, s. e56375, 2013.

Andersen, M; Hanson LG. A phatom-based validation framework for EEG-fMRI acquisition methods, Proceedings of the ESMRMB, 2012.

Vestergaard, M; Schulz J; Turner, R; Hanson LG. Motion tracking from gradient induced signals in electrode recordings. Proceedings of the ESMRMB, 368, 2011.

de Nijs, R., Miranda, MJ., Hansen, LK., Hanson, LG. Motion correction of single-voxel spectroscopy by independent component analysis applied to spectra from nonanesthetized pediatric subjects. Magn Reson Med 2009, 62(5), 1147-1154.

Søgaard, LV., Dorniok, T., Hengstenberg, F., Karpuk, S., Vestbo, J., Åkeson, P., Magnusson, P. Compressed Sensing for Hyperpolarized 3He 3D ADC Measurements. Oral presentation. Proc Intl Soc Magn Reson Med 2009, 7.

Hanson, LG. Is quantum mechanics necessary for understanding magnetic resonance? Concepts in Magnetic Resonance Part A 2008, 32A(5), 329-340.

Hanson, LG. A graphical simulator for teaching basic and advanced MR imaging techniques. Radiographics 2007, 27(6), e27.

Hanson, LG., Lund, TE., Hanson, CG. Encoding of electrophysiology and other signals in MR images. J. Magn Reson Imaging 2007, 25(5), 1059-1066. 

Hanson, LG., Lund, TE., Hanson, CG. Encoding and transmission of signals as RF signals for detection using an MR apparatus. WO/2005/116676, PCT/DK2005/000343 2005.

Andersen, IK., Szymkowiak, A., Rasmussen, CE., Hanson, LG., Marstrand, JR., Larsson, HB., Hansen, LK. Perfusion quantification using Gaussian process deconvolution. Magn Reson Med 2002, 48(2), 351-361.

Hanson, LG., Adalsteinsson, E., Pfefferbaum, A., Spielman, DM. Optimal voxel size for measuring global gray and white matter proton metabolite concentrations using chemical shift imaging. Magn Reson Med 2000, 44(1), 10-18.

Hanson, LG., Schaumburg, K., Paulson, OB. Reconstruction strategy for echo planar spectroscopy and its application to partially undersampled imaging. Magn Reson Med 2000, 44(3), 412-417.

News & Events

Group Members

Lars G. Hanson

Group Leader

Malte Laustsen

PhD student

Kristoffer Hougaard Madsen

Senior Researcher

Jakob Sørensen

MSc student

Patrick Lehmann

MSc student

External Collaborators

DTU Center for Magnetic Resonance

Technical University of Denmark, Lyngby (DTU Elektro) 

 Institute  of Biophysics

Chinese Academy of Sciences, Beijing, China

Max Planck Institute for Biological Cybernetics

Tübingen, Germany

DTU Biomedical Engineering

Technical University of Denmark, Lyngby (DTU Elektro) 

Lund University Bioimaging Centre

Lund, Sweden