Hyperpolarized MRI Research Group

Overall research areas Cardiac metabolism using Hyperpolarized 13C (HP13C) Metabolism of breast cancer disease using HP13 Metabolism of diabetic kidneys using HP13C Rapid metabolic imaging of HP13C Lung structure and function using HP3He

Jan Henrik Ardenkjær-Larsen Group leader DTU/GE/DRCMR Metabolic imaging using HP13C Hyperpolarization physics Formulation of compounds for hyperpolarization	Lise Vejby Søgaard Group leader DRCMR Rapid metabolic imaging of HP13C Cardiac metabolism using HP13C Lung function and structure using HP3He	Peter Magnusson DRCMR Rapid metabolic imaging of HP13C Cardiac metabolism using HP13C Lung function and structure using HP3He


Mette Hauge Lauritzen DRCMR Cardiac metabolism using HP13C	Christoffer Laustsen DRCMR, Aarhus University Kidney metabolism in diabetes using HP13C	Sascha Gude DRCMR Laboratory


Torsten Dorniok DRCMR, EU-PHeLINet Lung function and structure using HP3He	Frederik Hengstenberg DRCMR/Dept. of Cardiology and Respiratory Medicine Lung function and structure using HP3He




Objectives: The Hyperpolarization group aim for better understanding and diagnosis of major chronic diseases by means of hyperpolarization techniques. The group branches into two main areas of interest: 1. The use of hyperpolarized 3He-gas based techniques (HP3He) for studying chronic lung disease and 2. The use of hyperpolarized 13C-based MR techniques (HP13C) for studying the cell metabolism characteristics of chronic diseases. Ongoing projects evaluate the use of hyperpolarized 3He-gas (HP3He) for studying progression of emphysema for patients with chronic obstructive pulmonary disease (COPD) and explore new HP3He-based techniques for differentiating between COPD subgroups and for assessment of regional lung ventilation. Other projects based on the HP13C-technique focus on in vivo studies of altered cell metabolism in ischemic heart disease and on quantification of altered lactate metabolism in breast cancer. The group has further a strong interest in methods for rapid metabolic imaging of hyperpolarized compounds as well as in formulation of new metabolically active compounds that can be hyperpolarized and followed in vivo for studies of metabolic pathways currently not detectable. Resources: For HP3He-research the group has access to a multinuclear 1.5 T clinical Siemens MR-scanner with a 3He torso coil (Fraunhofer institute) and a gas delivery applicator from Mainz University. Hyperpolarized 3He-gas is delivered from Mainz University. For HP13C-research the hyperpolarization group has access to a 4.7 T pre-clinical Varian MR-scanner with dedicated RF-coils for the 13C-nucleus and with physiological monitoring equipment. For hyperpolarizing 13C the group has access to a HyperSense (Oxford Instruments) and a prototype (GE Healthcare) DNP polarizer. Publications (2006-2009): Stavngaard T, Søgaard LV, Batz M, Schreiber WG, Dirksen A Progression of emphysema evaluated by MRI using hyperpolarized 3He (HP 3He) measurements in patients with alpha-1 antitrypsin deficiency (A1AT), compared with CT and lung function tests Acta Radiol. 50(9):1019-26, 2009 Diaz S, Casselbrant I, Piitulainen E, Magnusson P, Peterson B, Pickering E, Tuthill T, Ekberg O, Akeson P Progression of emphysema in a 12-month hyperpolarized 3He-MRI study: lacunarity analysis provided a more sensitive measure than standard ADC analysis Acad Radiol. 16(6):700-7, 2009 van Beek EJ, Dahmen AM, Stavngaard T, Gast KK, Heussel CP, Krummenauer F, Schmiedeskamp J, Wild JM, Søgaard LV, Morbach AE, Schreiber LM, Kauczor HU Hyperpolarised 3-He MRI vs HRCT in COPD and normal volunteers - PHIL trial Eur Respir J. Jun 18. [Epub ahead of print], 2009 Diaz S, Casselbrant I, Piitulainen E, Magnusson P, Peterson B, Wollmer P, Leander P, Ekberg O, Akeson P Validity of the Apparent Diffusion Coefficient Hyperpolarized 3He MRI Using MSCT and Pulmonary Function Test as References Eur J Radiol. 71(2):257-63, 2009 Diaz S, Casselbrant I, Piitulainen E, Pettersson G, Magnusson P, Peterson B, Wollmer P, Leander P, Ekberg O, Akeson P Hyperpolarized 3He apparent diffusion coefficient MRI of the lung: Reproducibility and volume dependency in healthy volunteers and patients with emphysema J. Magn. Reson. Imaging. 27:763-770, 2008 Golman K, Petersson JS, Magnusson P, Johansson E, Åkeson P, Chai CM, Hansson G, Månsson S Cardiac metabolism measured noninvasively by hyperpolarized 13C MRI Magn. Reson. Med. 59: 1005-1013, 2008 Magnusson P, Johansson E, Månsson S, Petersson JS, Chai CM, Hansson G, Golman K Passive catheter tracking during interventional MRI using hyperpolarized 13C Magn. Reson. Med. 57(6):1140-1147, 2007 Mansson S, Johansson E, Magnusson P, Chai CM, Hansson G, Petersson JS, Stahlberg F, Golman K 13C imaging – a new diagnostic platform Eur. Radiol. 16(1), 57-67, 2006 Collaborators: HP3He Institute of Physics, University of Mainz, Germany Dep. Of Cardiology and Respiratory Medicine, Copenhagen University Hospital Hvidovre HP13C Bartholin Institute, Copenhagen Biocenter Department of Pathology, Copenhagen University Hospital Hvidovre Niels Bohr Institute, University of Copenhagen GE Healthcare

DRCMR

Danish Research Centre for Magnetic Resonance

Hyperpolarized MRI Research Group