| Education, Training, Clinical appointments
1989-1995 Residency in Internal Medicine (Trier, Germany), Neurosurgery (Koblenz, Germany) and Neurology (Paderborn, Germany)
1995-2002 Clinical Research Fellow, Dept. of Neurology, Munich University of Technology, Germany
2002 - Aug. 2008 Consultant, Department of Neurology, Christian-Albrechts-Univ. Kiel, Germany
Since Sept. 2008 Consultant (Overlæge), DRCMR/MR-Department, Hvidovre University Hospital, Hvidovre, Denmark
Since Feb. 2009 Head of Research, DRCMR/MR-Department, Hvidovre University Hospital, Hvidovre, Denmark Research Experience / Academic Appointments
1991 MD (Dr. med.), Medical faculty, Saarland University, Germany
2000-2002 Postdoc Positions at Sobell Department, Institute of Neurologie London,UK and the Department of Brain Pathophysiology, Kyoto University, Japan
2002-2008 Principle Invstigator for Neuroimmaging of Motor Control and Movement Disorders, Brain Imaging Center “NeuroImage-Nord”, Hamburg-Kiel-Lübeck 2003 Privatdozent (Lecturer) at the Department of Neurology of the Medical Faculty of the Christian-Albrechts-University Kiel
2004-2008 Full professor for „Functional Immaging and Movement Disorders“ at the Christian-Albrechts-University Kiel
Feb. 2009 Full professor for "Functional brain imaging", Dept. of Neurology, Psychiatry and Senses, Faculty of Health Sciences, University of Copenhagen Current areas of research
• Sensorimotor control and movement disorders
• Linking functional neuroimaging with trait markersof serotonergic neurotransmission (CIMBI Project 4)
• Functional neuroimaging of neuropsychiatic disorders
• Multimodal in vivo mapping (fMRI, EEG, TMS, PET) of human brain networks
• Characterization of functional brain states with non-invasive brain mapping techniques
• Probing cortico-cortical and cortico-subcortical connectivity (DTI, multi-site TMS, fMRI)
• Modifying brain states with transcranial neurostimulation (TMS, TDCS)
• Genetically informed neuroimaging
Research tools
Functional (fMRI, PET and EEG) and structural brain mapping (VBM of T1w-MRI, DWI) with a focus on multimodal integration (EEG-fMRI, TMS-fMRI)
Psychophysical measurements in conjunction with neuronavigated TMS (virtual lesion technique)
Multi-site TMS to probe cortico-cortical connectivity
Inducing brain reorganizatiaon with rTMS and TDCS
Grants and Awards
Grant support (2000-2009): Deutsche Forschungsgemeinschaft (DFG: Si 738/1; DE 438/7; Project A6 - SFB 654 Plasticity and Sleep,VE 110/14, MU 1692/2), Bundesministerium für Bildung und Forschung Germany (01 GO 0511, 01 GW 0562, 01 GW 0663), Volkswagen-Foundation (I / 78-553; I / 79-932), Benign Essential Blepharospasm Research Foundation, Det Frie Forskningsråd - Sundhed & Sygdom (Grant 271-08-0669). Jeppe Juhl og Hustru Ovita Juhl’s Mindelegat 2008, Dansk Scleroseforeningen, Henry Hansen og Hustrus Legat 2009.
Editorial board member of NeuroImage and Brain Stimulation, Member of the Scientific advisory Board of the Luria Institut, Konstanz, Germany
2000-2002 Post-doctoral fellow, Institute of Neurology, UCL, London,UK (educational grant)
2002 Visiting Professor, Kyoto University, Japan
2003 Oppenheim-Prize, German Dystonia Research Foundation
2009 Richard Jung Prize, German Society for Clinical Neurophysiology
Publications
162 peer-reviewed publications (154 publications in English)
142 original papers and 20 reviews, 35 papers have been cited 35 times or more (Hirsch index: 35)
Cumulative impact factor (IF): 726, Mean IF: 4.78 (based on publications in English)
Cumulative sum of scientific citations: 3341
20 selected publications (2003-2009)
1. Siebner HR, Tormos JM, Ceballos-Baumann AO, Auer C, Catala MD, Conrad B, Pascual-Leone A (1999) Reinforcement of intracortical inhibitory circuitry by low-frequency repetitive transcranial magnetic stimulation in patients with writer´s cramp. Neurology 52:529-537.
2. Siebner HR, Peller M, Bartenstein P, Willoch F, Boecker H, Auer C, Schwaiger M, Conrad B (2001) Suprathreshold electromagnetic stimulation of the left primary motor hand area activates remote frontal motor output areas: a 18FDG-PET study. Human Brain Mapp 12:157-167.
3. Lee L, Siebner HR, Rowe JB, Rizzo V, Rothwell JC, Frackowiak RS, Friston KJ. (2003) Acute remapping within the motor system induced by low-frequency repetitive transcranial magnetic stimulation. J Neurosci 23:5308-5318.
4. Siebner HR, Lang N, Rizzo V, Nitsche MA, Paulus W, Lemon RN, Rothwell JC (2004) Preconditioning of low-frequency repetitive transcranial magnetic stimulation with transcranial direct current stimulation: evidence for homeostatic plasticity in the human motor cortex. J Neurosci 24:3379-3385.
5. Buhmann C, Binkofski F, Klein C, Büchel C, van Eimeren T, Erdmann C, Hedrich K, Kasten M, Hagenah J, Deuschl G, Pramstaller PP, Siebner HR (2005) Motor reorganization in asymptomatic carriers of a single mutant Parkin allele: a human model for presymptomatic parkinsonism. Brain 128: 2732-2746.
6. Quartarone A, Rizzo V, Bagnato S, Morgante F, Sant’Angelo A, Romano M, Crupi D, Girlanda P, Rothwell JC, Siebner HR (2005) Homeostatic-like plasticity of the primary motor hand area is impaired in focal hand dystonia. Brain 128:1943-1950.
7. Bäumer T, Bock F, Koch J, Lange R, Rothwell JC, Siebner HR, Münchau A (2006) Magnetic stimulation of human premotor or motor cortex produces interhemispheric facilitation through distinct pathways. J Physiol 572:857-868.
8. Peller M, Zeuner KE, Munchau A, Quartarone A, Weiss M, Knutzen A, Hallett M, Deuschl G, Siebner HR (2006) The basal ganglia are hyperactive during the discrimination of tactile stimuli in writer´s cramp. Brain 129:2697-2708.
9. Ponseti J, Bosinski HA, Wolff S, Peller M, Jansen O, Mehdorn HM, Büchel C, Siebner HR (2006) A functional endophenotype for sexual orientation in humans. NeuroImage 33:825-833.
10. van Eimeren T, Wolbers T, Münchau A, Büchel C, Weiller C, Siebner HR (2006) Implementation of visuospatial cues in response selection. NeuroImage 29:286-294.
11. Klöppel S, Vongerichten A, van Eimeren T, Frackowiak RSJ, Siebner HR (2007) Can left-handedness be switched? – insights from an early switch of handwriting. J Neurosci 27:7847-7853.
12. Bergmann TO, Mölle M, Marshall L, Kaya-Yildiz L, Born J, Siebner HR (2008) A local signature of LTP- and LTD-like plasticity in human NREM sleep. Eur J Neurosci 27:2241-2249.
13. Kloeppel S, Bäumer T, Kroeger J, Koch MA, Büchel C, Münchau A, Siebner HR (2008) The cortical motor threshold reflects microstructural properties of cerebral white matter. NeuroImage 40:1782-1791.
14. Moeller F, Siebner HR, Wolff S, Muhle H, Boor R, Granert O, Jansen O, Stephani U, Siniatchkin M (2008) Changes in activity of striato-thalamo-cortical network precede generalized spike wave discharges. NeuroImage 39:1839-1849.
15. Kirov R, Weiss C, Siebner HR, Born J, Marshall L (2009) Wake slow oscillation electrical brain stimulation promotes EEG theta activity and memory encoding. Proc Natl Acad Sci U S A 106:15460-15465.
16. Moeller F, Siebner HR, Ahlgrimm N, Wolff S, Muhle H, Granert O, Boor R, Jansen O, Gotman J, Stephani U, Siniatchkin M (2009) fMRI activation during spike and wave discharges evoked by photic stimulation. Neuroimage 48:682-695.
17. Ponseti J, Granert O, Jansen O, Wolff S, Mehdorn HM, Bosinski HA, Siebner HR (2009) Assessment of sexual orientation using the hemodynamic brain re-sponse to visual sexual stimuli. J Sex Med 6:1628-1634.
18. Thomalla G, Siebner HR, Jonas M, Bäumer T, Biermann-Ruben K, Hummel F, Gerloff Müller-Vahl C, Schnitzler A, Orth M, Münchau A (2009) Structural changes in the somatosensory system correlate with tic severity in Gilles de la Tourette syndrome. Brain 132:765-777.
19. Van Nuenen BFL, Weiss MM, Bloem BR, Reetz K, van Eimeren T, Lohmann K, Hagenah J, Pramstaller PP, Binkofski F, Klein C, Siebner HR (2009) Heterozygous carriers of a Parkin or PINK1 mutation share a common functional endophenotype. Neurology 72:1041-1047.
20. Weiss MM, Wolbers T, Peller M, Witt K, Marshall L, Buchel C, Siebner HR (2009) Rotated alphanumeric characters do not automatically activate frontoparietal areas subserving mental rotation. NeuroImage 44:1063-1073. |
