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Thursday, 13 July 2023 00:40

Postdoc in mapping cortical layers using multi-modal imaging

Are you fascinated by the potential of multi-modal imaging to explore the intricate details of cortical layers across various image resolutions? Are you motivated to develop an imaging approach that not only detects disease-related cortical layer changes but also holds promise for future clinical applications? If so, we have an exciting opportunity for you to join our cross-disciplinary research team as part of the Xtreme-CT project, generously supported by the Novo Nordisk Foundation's synergy program.

As a member of our team, you will contribute to the development of a groundbreaking 3D multiscale tomographic imaging approach at the MAXIV synchrotron facility. Our aim is to collect data at different fields of view and voxel sizes within a single acquisition, including imaging at the cellular level with sub-micrometer voxel sizes. Leveraging your curiosity and expertise, alongside a preclinical MRI scanner, you will work towards establishing a correlation between MRI-based cortical layers fingerprint metrics and 3D multiscale tomographic imaging.

Joining us means becoming part of an inspiring research environment, collaborating with world-class experts. Your contributions will help shape the future of multi-modal imaging and its potential clinical applications, making a lasting impact on the field.

The Danish Research Centre for Magnetic Resonance (DRCMR) at Copenhagen University Hospital Hvidovre (Denmark) is seeking a 3-year postdoc in mapping cortical layers using multi-modal imaging. You will be joining the cross-disciplinary research team of Prof Tim Dyrby in the Xtreme-CT project which is a collaboration with Prof. Anders Dahl, DTU Compute, Technical University of Denmark (DTU), Prof. Henrik Birkedal, iNano, Aarhus University, and Prof. Henning Friis Poulsen, DTU physics. The Xtreme-CT projects include expertise in machine learning, MRI, and X-ray physics applied to bone and brain anatomies.

Your responsibilities:

  • To establish multi-dimensional MRI acquisition using a preclinical MRI scanner and a modeling framework to map fingerprints of cortical layers in the brain.
  • To cross-link cortical layer mapping using MRI with high-resolution x-ray 3D tomographic imaging.
  • To actively collaborate with team members within the cross-disciplinary Xtreme-CT project such as taking part in preparing samples for and participating in synchrotron imaging experiments as well as contributing to the multi-modal image analysis.

Your profile:

You should be a highly motivated internationally minded team player with the following qualifications:

  • Ph.D. degree in MRI physics or relevant field with a strong foundation in MRI.
  • Proficiency in experimental MRI techniques. It is a plus if you have experience with preclinical scanner systems but is not a requirement.
  • Proven expertise in relaxometry MRI, diffusion MRI, and image analysis. Having Machine Learning experience is a plus.
  • Experiences and knowledge about x-ray microCT imaging is a plus but not a requirement as you will be trained for this. 
  • Fluency in English writing and scientific communication.
  • Demonstrated ability to work independently and think critically, while also effectively collaborating and contributing to the research team.

About us:

The project will be carried out at the Danish Research Centre for Magnetic Resonance (DRCMR) which is a leading research centre for biomedical MRI in Europe (www.drcmr.dk). Our mission is to triangulate MR physics and basic physiology from preclinical to clinical research. Approximately 75 researchers from a diverse range of disciplines are currently pursuing basic and clinically applied MR research and its validation with a focus on structural, functional, and metabolic MRI of the human brain and its disorders. The DRCMR is embedded in the Center for Functional and Diagnostic Imaging and Research, a large diagnostic imaging department including all biomedical imaging modalities at the Copenhagen University Hospital Hvidovre.

Our preclinical labs perform basic research in functional, microstructure, and plasticity imaging which is centered around the 7T Bruker BioSpec MRI system. The MRI scanner is fully equipped with powerful gradients and a cryo-coil system for rodent imaging. The preclinical labs include a GMO2-classified virus lab and are fully equipped with stereotaxic surgery equipment and electrophysiology facilities. Our cross-disciplinary research team designs and validates new types of diffusion MRI and quantitative MRI imaging technologies to non-invasively disentangle the microstructure of brain network and function. Here, it is key to have a true interest in how the microanatomy of the normal and diseased brain can look and how it impacts brain function. It is our vision to improve future non-invasive imaging technologies for better patient diagnosis.

Your position:

The candidate will be employed for a period of 36 months at the Danish Research Centre for Magnetic Resonance where he/she will be an active part of the Microstructure and Plasticity Group (drcmr.dk/map) and the Preclinical Method group, both led by Professor Tim B. Dyrby.

Salary and Terms of Employment

Salary, pension, and terms of employment are by the agreement between the Danish Regions (Danske Regioner) and the relevant professional organization. The salary depends on background education and seniority. Further, supplements can be negotiated. Note that candidates coming from abroad may be eligible for tax reductions. The position is open for candidates of all nationalities. We expect you to start on November 1st, 2023, or soon thereafter.

We see diversity as a strength and encourage all persons regardless of gender, age, ethnicity, disabilities, or religion to apply.

Applications should include a cover letter, CV, and list of publications together with the names of three references. Applications must be submitted online through the RegionH job portal.

Application deadline: August 15th, 2023 at 23:59 CET)

For further information regarding the position please contact Professor Tim B. Dyrby