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Shape Abnormalities of the Caudate Nucleus Correlate with Poorer Gait and Balance: Results from a Subset of the LADIS Study

Macfarlane MD, Looi JCL, Walterfang M, Spulber G, Velakoulis D, Styner M, Crisby M, Orndahl E, Erkinjuntti T, Waldemar G, Garde E, Hennerici MG, Bäzner H, Blahak C, Wallin A and Wahlund L

2015

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Functional deficits seen in several neurodegenerative disorders have been linked with dysfunction in frontostriatal circuits and with associated shape alterations in striatal structures. The severity of visible white matter hyperintensities (WMHs) on magnetic resonance imaging has been found to correlate with poorer performance on measures of gait and balance. This study aimed to determine whether striatal volume and shape changes were correlated with gait dysfunction.
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