spacer

spacer

spacer

spacer

Three-Week Bright-Light Intervention Has Dose-Related Effects on Threat-Related Corticolimbic Reactivity and Functional Coupling

Fisher PM, Korsbak Madsen M, McMahon B, Holst KK, Andersen SB, Laursen HR, Hasholt LF, Siebner HR and Knudsen GM

2014

cc
Bright-light intervention is reported to successfully treat depression, in particular seasonal affective disorder, but the neural pathways and molecular mechanisms mediating its effects are unclear. An amygdala-prefrontal cortex corticolimbic circuit regulates responses to salient environmental stimuli (e.g., threat) and may underlie these effects. Serotonin signaling modulates this circuit and is implicated in the pathophysiology of seasonal and other affective disorders.
cc