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Influence of waveform and current direction on short-interval intracortical facilitation: a paired-pulse TMS study

Delvendahl I, Lindemann H, Jung NH, Pechmann A, Siebner HR and Mall V

2014

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Transcranial magnetic stimulation (TMS) of the human primary motor hand area (M1-HAND) can produce multiple descending volleys in fast-conducting corticospinal neurons, especially so-called indirect waves (I-waves) resulting from trans-synaptic excitation. Facilitatory interaction between these I-waves can be studied non-invasively using a paired-pulse paradigm referred to as short-interval intracortical facilitation (SICF).
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