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Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects

Madsen K, Erritzøe D, Mortensen EL, Gade A, Madsen J, Baaré WFC, Knudsen GM and Hasselbalch SG

2011

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Pharmacological manipulation of serotonergic neurotransmission in healthy volunteers impacts on cognitive test performance. Specifically, markers of serotonin function are associated with attention and executive functioning, long-term memory, and general cognitive ability. The serotonin transporter (SERT) protein is a key regulator in the serotonin system. We hypothesized that higher performance on tests sensitive to serotonin would be associated with higher SERT levels in specific fronto-striatal brain regions.
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