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Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding
Frøkjær V, Erritzøe D, Juul A, Nielsen FÅ, Holst K, Svarer C, Madsen J, Paulson OB and Knudsen GM2010
ccccSex-hormones influence brain function and are likely to play a role in the gender predisposition to mood and anxiety disorders. Acute fluctuations of sex-hormone levels including hormonal replacement therapy appear to affect serotonergic neurotransmission, but it is unknown if baseline levels affect serotonergic neurotransmission. This study was undertaken to examine if baseline levels of endogenous sex hormones are associated with cerebral serotonin 2A (5-HT(2A)) receptor binding in men.