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Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS

Sørensen PS, Tscherning M, Kahr Mathiesen H, Langkilde A, Ross C, Ravnborg M and Bendtzen K

2006

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We measured neutralizing antibodies (NABs) and the in vivo biologic response to interferon-beta on neopterin and beta(2)-microglobulin blood levels. All NAB-negative patients had an in vivo biologic response (full or partial), whereas all high-level positive patients had no response. High-level NAB patients had more MRI activity than NAB-negative patients (p = 0.031). Patients with a full response had less MRI activity than patients without biologic response (p = 0.032).
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