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Anouk Marsman



+45 3862 6678


Research Fellow

Personal webpage


Research Interests

I am leading MR spectroscopy research at DRCMR and as such I initiated several neuroscientific studies on brain chemistry in health and disease. I am heading studies on normal ageing and neurodegenerative diseases, schizophrenia, and development of novel techniques. I am also a key player in collaborative and international consortium studies on e.g. migraine, diabetes and ultra-high field MRI method standardisation, where I am responsible for MR spectroscopy.

Curriculum Vitae



PhD Neuroscience, Utrecht University, The Netherlands


MSc Biology (Cum Laude), University of Groningen, The Netherlands


2019 - Present

Research Fellow, DRCMR

2015 - 2019

Postdoc, DRCMR

2013 - 2015

Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA

2008 - 2013

Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands

Full CV


Video Pitch: Presentation 

Younis S, Hougaard A, Christensen CE, Vestergaard MB, Petersen ET, Boer VO, Paulson OB, Ashina M, Larsson HBW*, Marsman A*. Feasibility of pharmacokinetic mapping using 1H-MRS at 3T and 7T. Front Neurosci, 2020;14:559314. doi: 10.3389/fnins.2020.559314

Coughlin JM, Yang K*, Marsman A*, Pradhan S*, Wang M, Ward RE, Bonekamp S, Ambinder EB, Higgs CP, Kim PK, Edwards JA, Varvaris M, Wang H, Posporelis S, Ma S, Tsujimura T, Edden RAE, Pomper MG, Sedlak TW, Fournier M, Schretlen DJ, Cascella NG, Barker PB, Sawa A. A multimodal approach to studying the relationship between peripheral glutathione, brain glutamate, and cognition in health and in schizophrenia. Mol Psychiatry, 2020;online ahead of print. doi: 10.1038/s41380-020-00901-5

Lind A, Boraxbekk CJ, Petersen ET, Paulson OB, Siebner HR, Marsman A. Regional myo-inositol, creatine and choline levels are higher at older age and scale negatively with visuo-spatial working memory: A cross-sectional proton MR spectroscopy study at 7 tesla on normal cognitive ageing. J Neurosci, 2020;40(42):8149-8159. doi: 10.1523/JNEUROSCI.2883-19.2020

Cuypers K, Marsman A. Transcranial magnetic stimulation and magnetic resonance spectroscopy: opportunities for a bimodal approach in human neuroscience (invited review). Neuroimage, 2020;online ahead of print. doi: 10.1016/j.neuroimage.2020.117394

Boer VO, Andersen M, Lind A, Lee NG, Petersen ET*, Marsman A*. MR spectroscopy using static higher-order shimming with dynamic linear terms (HOS-DLT) for improved water suppression, interleaved MRS-fMRI, and navigator-based motion correction at 7T. Magn Reson Med, 2020;84(3):1101-1112. doi: 10.1002/mrm.28202

Andersen M, Björkmann-Burtscher IM, Marsman A, Petersen ET, Boer VO. Improvement in diagnostic quality of structural and angiographic MRI of the brain using motion correction with interleaved, volumetric navigators. PLoS One, 2019;14(5):e0217145. doi: 10.1371/journal.pone.0217145

Magnusson PO, Boer VO, Marsman A, Paulson OB, Hanson LG, Petersen ET. Gamma-aminobutyric acid edited echo-planar spectroscopic imaging (EPSI) with MEGA-sLASER at 7T. Magn Reson Med, 2019;81(2):773-780. doi: 10.1002/mrm.27450

Marsman A, Hulshoff Pol HE. Glutamatergic neurotransmission in schizophrenia. In: Cahn W, Krabbendam L, Myin-Germeys I, Bruggeman R, De Haan L (eds.), Handbook Schizophrenia, 2nd ed. (Dutch); Utrecht, The Netherlands, 2019:371-385. ISBN 9789058983251

Egerton A, Marsman A, Broberg BV, Hulshoff Pol HE. Editorial: MR spectroscopy in neuropsychiatry. Front Psychiatry, 2018;9:197. doi: 10.3389/fpsyt.2018.00197

Posporelis S*, Coughlin J*, Marsman A, Pradhan S, Tanaka T, Wang H, Varvaris M, Ward R, Higgs C, Edwards JA, Ford CN, Kim PK, Lloyd AM, Edden RA, Schretlen D, Cascella NG, Barker PB, Sawa A. Decoupling of brain temperature and glutamate in recent-onset of schizophrenia: a 7 Tesla 1H-MRS study. Biol Psychiatry CNNI, 2018;3(3):248-254. doi: 10.1016/j.bpsc.2017.04.003

Marsman A, Mandl RCW, Klomp DWJ, Cahn W, Kahn RS, Luijten PR, Hulshoff Pol HE. Intelligence and brain efficiency: investigating the association between working memory performance, glutamate and GABA. Front Psychiatry, 2017;8:154. doi: 10.3389/fpsyt.2017.00154

Bhogal AA, Schür RR, Houtepen LC, Van de Bank B, Boer VO, Marsman A, Barker PB, Scheenen T, Wijnen JP, Vinkers CH, Klomp DWJ. 1H-MRS processing parameters affect metabolite quantification: the urgent need for uniform and transparent standardization. NMR Biomed, 2017;30(11):e3804. doi: 10.1002/nbm.3804

De Jonge JC, Vinkers CH, Hulshoff Pol HE, Marsman A. Neurobiological mechanisms of GABA in schizophrenia: a comprehensive review of postmortem and in vivo studies. Front Psychiatry, 2017;8:118. doi: 10.3389/fpsyt.2017.00118

Marsman A, Boer VO, Luijten PR, Hulshoff Pol HE, Klomp DWJ, Mandl RCW. Detection of glutamate alterations in the human brain using 1H-MRS: Comparison of STEAM and sLASER at 7T. Front Psychiatry, 2017;8:60. doi: 10.3389/fpsyt.2017.00060 

Coughlin JM, Tanaka T, Marsman A, Wang H, Bonekamp S, Higgs C, Kim PK, Edwards JA, Varvaris M, Wang H, Posporelis S, Ma S, Tsujimura T, Edden RA, Pomper MG, Sedlak T, Do K, Schretlen D, Cascella NG, Barker PB, Sawa A. Decoupling of N-acetyl aspartate and glutamate within the dorsolateral prefrontal cortex in schizophrenia. Curr Mol Med, 2015;15(2):176-183. doi: 10.2174/1566524015666150303104811

Marsman A. Magnetic resonance spectroscopy, In: Hulshoff Pol HE, Aleman A (eds.), Imaging of the brain (Dutch); Utrecht, The Netherlands, 2015:23-32. ISBN 9789058982629

Marsman A, Mandl RCW, Klomp DWJ, Bohlken MM, Boer VO, Andreychenko A, Cahn W, Kahn RS, Luijten PR, Hulshoff Pol HE. GABA and glutamate in schizophrenia: a 7T 1H-MRS study. Neuroimage Clin, 2014;6:398-407. doi: 10.1016/j.nicl.2014.10.005

Marsman A. Glutamate and GABA in schizophrenia. Utrecht University (dissertation). 2013. ISBN: 978-94-6108-521-4

Marsman A, Mandl RCW, Van den Heuvel MP, Boer VO, Wijnen JP, Klomp DWJ, Luijten PR, Hulshoff Pol HE. Glutamate changes in healthy young adulthood. Eur Neuropsychopharmacol, 2013;23(11):1484-1490. doi: 10.1016/j.euroneuro.2012.11.003

Marsman A, Van den Heuvel MP, Klomp DWJ, Kahn RS, Luijten PR, Hulshoff Pol HE. Glutamate in schizophrenia: a focused review and meta-analysis of 1H-MRS studies. Schizophr Bull, 2013;39(1):120-129. doi: 10.1093/schbul/sbr069

Marsman A, Van den Heuvel MP, Hulshoff Pol HE, Glutamatergic neurotransmission in schizophrenia, In: Cahn W, Krabbendam L, Myin-Germeys I, Bruggeman R, De Haan L (eds.), Handbook Schizophrenia (Dutch); Utrecht, The Netherlands, 2011: 305-312. ISBN 9789058981790