Relaxation time contrast T1- and T2-weighted imaging The work horses of clinical imaging: Always available, reliable and require little post-processing Sensitive to pathology T1- and T2-weighted sequences. Transversal T2-relaxation Loss of signal due to dephasing of spins Reversible loss caused by inhomogeneity Irreversible loss caused by spin-spin interactions, elastic and inelastic Longitudinal T1-relaxation Return of Mz to equilibrium caused by inelastic spin-spin interactions only (so T2