Raffaele Dubbioso



+45 4274 0033


PhD Student

Personal webpage


Research Interests

I'm a Neurologist and Clinical Neurophysiologist. 
My main research field is brain plasticity. I'm also interested in understanding the mechanisms of sensory-motor integration in healthy subjects and in patients affected by neurological diseases (focal hand dystonia, Parkinson’s disease). 
I mainly employ non invasive brain stimulation techniques in combination with neuroimaging studies (functional and structural MRI)

Research Groups


Curriculum Vitae



Neurology degree- 50/50 (cum laude) – University of Naples “Federico II”


Graduate cum laude Medical Doctor – University of Naples “Federico II”


2014 -

PhD student in Neuroscience at University of Naples “Federico II”

2014 -

PhD Student at DRCMR


Manganelli F, Pisciotta C, Iodice R, Calandro S, Dubbioso R, Ranieri A, Santoro L. Case of acute motor conduction block neuropathy (AMCBN). Muscle Nerve 2009;39:224-226.

Manganelli F, Vitale C, Santangelo G, Pisciotta C, Iodice R, Cozzolino A, Dubbioso R, Picillo M, Barone P, Santoro L. Functional involvement of central cholinergic circuits and visual hallucinations in Parkinson's disease. Brain 2009;132:2350-2355.

Manganelli F, Pisciotta C, Iodice I, Dubbioso R, Santoro L. Reply. Muscle Nerve 2010;41:285.

Pisciotta C, Manganelli F, Dubbioso R, Ruggiero L, Iodice R, Santoro L. Thermosensitive hereditary neuropathy with liability to pressure palsy. Muscle Nerve 2011;43:448-449.

Manganelli F, Pisciotta C, Dubbioso R, Iodice R, Criscuolo C, Ruggiero L, De Michele G, Santoro L. Electrophysiological characterisation in hereditary spastic paraplegia type 5. Clin Neurophysiol 2011;122:819-822.

Manganelli F, Dubbioso R, Nolano M, Iodice R, Pisciotta C, Provitera V, Ruggiero L, Serlenga L, Barbieri F, Santoro L. Autoimmune autonomic ganglionopathy: a possible postganglionic neuropathy. Arch Neurol 2011;68:504-507.

Dubbioso R, Moretta P, Manganelli F, Fiorillo C, Iodice R, Trojano L, Santoro L. Executive functions are impaired in heterozygote patients with oculopharyngeal muscular dystrophy. J Neurol 2012;259:833-837. 

Di Lazzaro V, Manganelli F, Dileone M, Notturno F, Esposito M, Capasso M, Dubbioso R, Pace M, Ranieri F, Minicuci G, Santoro L, Uncini A. The effects of prolonged cathodal direct current stimulation on the excitatory and inhibitory circuits of the ipsilateral and contralateral motor cortex. J Neural Transm 2012;119:1499-1506.

Manganelli F, Pisciotta C, Dubbioso R, Maruotti V, Iodice R, Notturno F, Ruggiero L, Vitale C, Nolano M, Uncini A, Santoro L. Electrophysiological comparison between males and females in HNPP. Neurol Sci. 2013;34:1429-1432.

Manganelli F, Dubbioso R, Pisciotta C, Antenora A, Nolano M, De Michele G, Filla A, Berardelli A, Santoro L. Somatosensory temporal discrimination threshold is increased in patients with cerebellar atrophy. Cerebellum 2013;12:456-459.

Manganelli F, Dubbioso R, Esposito M, Marinò C, Pisciotta C, Pignatelli S, Santoro L. A case of congenital cataracts, facial dysmorphisms, neuropathy and hyperkinetic movement disorder. Mov Disord 2013;28:559-560.

Dubbioso R, Nolano M, Mazzarella R, Rivellese AA, Manganelli F. Mutilating fingertip ulcers in uncontrolled type 1 diabetes mellitus. Neurol Sci. 2014;35:123-124.

Esposito M, Fasano A, Crisci C, Dubbioso R, Iodice R, Santoro L. The combined treatment with orbital and pretarsal botulinum toxin injections in the management of poorly responsive blepharospasm. Neurol Sci. 2014;35:397-400.

Dubbioso R, Pappatà S, Quarantelli M, D’Arco F, Manganelli F, Esposito M, Santoro L. Atypical clinical and radiological presentation of cryptococcal choroid plexitis in an immunocompetent woman. J Neurol Sci. 2013;334:180-182.

Dubbioso R, Marcelli V, Manganelli F, Iodice R, Esposito M, Santoro L. Anti-GAD antibody ocular flutter: expanding the spectrum of autoimmune ocular motor disorders. J Neurol. 2013;260:2675-2677.

Dubbioso R *, Manganelli F*, Iodice R, Topa A, Dardis A, Russo CV, Ruggiero L, Tozza S, Filla A, Santoro L. Central cholinergic dysfunction in the adult form of Niemann Pick disease type C: a further link with Alzheimer's disease? J Neurol. 2014;26:804-808.

Iodice R, Manganelli F, Dubbioso R, Ruggiero L, Santoro L. Teaching video neuroimages: clonus of the lower jaw: an old sign that comes back. Neurology. 2014 Mar 18;82(11):e96.

Ruggiero L, Fiorillo C, Tessa A, Manganelli F, Iodice R, Dubbioso R, Vitale F, Storti E, Soscia E, Santorelli F, Santoro L. Muscle fiber type disproportion (FTD) in a family with mutations in the LMNA gene. Muscle Nerve. 2015;51:604-608.

Iodice R, Dubbioso R, Topa A, Ruggiero L, Pisciotta C, Esposito M, Tozza S, Santoro L, Manganelli F. Electrophysiological characterization of adult-onset Niemann-Pick type C disease.  J Neurol Sci. 2015;348:262-265. 

Dubbioso R, Cerillo I, D'Arco F, D'Amico A, Pettinato G, Boldorini R, Santoro L, Manganelli F. Isolated intracranial Mycobacterium avium complex granulomas in an immune-competent man. J Neurol Sci. 2015;349:264-265.

Topa A, Dubbioso R, Iodice R, Santoro L, Manganelli F. Chronic inflammatory demyelinating polyneuropathy mimicking an acute painful diabetic neuropathy. Neurol Sci. 2015 Feb 28.

Esposito M, Dubbioso R, Apisa P, Allocca R, Santoro L, Cesari U. Spasmodic dysphonia follow-up with videolaryngoscopy and voice spectrography during treatment with botulinum toxin. Neurol Sci. 2015 May 13.

Dubbioso R, Picillo M*, Iodice R, Iavarone A, Pisciotta C, Spina E, Santoro L,  Barone P, Amboni M, Manganelli F. Short-latency afferent inhibition in patients with Parkinson's disease and freezing of gait. J Neural Transm. 2015 Jul 31.

Dubbioso R, Pellegrino G, Antenora A, De Michele G, Filla A, Santoro L, Manganelli F. The Effect of Cerebellar Degeneration on Human Sensori-motor Plasticity. Brain Stimul. 2015;8:1144-1150. 

Iodice R, Dubbioso R, Ruggiero L, Santoro L, Manganelli F. Anodal transcranial direct current stimulation of motor cortex does not ameliorate spasticity in multiple sclerosis. Restor Neurol Neurosci. 2015;33:487-492.

Dubbioso R, Ranucci G, Marcello E, Di Dato F, Topa A, Quarantelli M, Matarazzo M, Santoro L, Manganelli F, Iorio R. Subclinical neurological involvement does not develop if Wilson’s disease is treated early. Parkinsonism Relat Disord. 2016;24:15-19

Iodice R,  Carotenuto A, Dubbioso R, Cerillo I,  Santoro L, Manganelli F. Multimodal evoked potentials follow up in multiple sclerosis patients under fingolimod therapy. J Neurol Sci. 2016.