Sorensen PS;Tscherning T;Mathiesen HK;Langkilde AR;Ross C;Ravnborg M;Bendtzen K
Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS
Neurology 2006, 67(9), , 1681-1683

We measured neutralizing antibodies (NABs) and the in vivo biologic response to interferon-beta on neopterin and beta(2)-microglobulin blood levels. All NAB-negative patients had an in vivo biologic response (full or partial), whereas all high-level positive patients had no response. High-level NAB patients had more MRI activity than NAB-negative patients (p = 0.031). Patients with a full response had less MRI activity than patients without biologic response (p = 0.032)