Mark Schram Christensen
Group leader
DRCMR, IFI, INF Cognitive motor control
Sensory-motor integration
Forward models | Hartwig Siebner
Group leader
DRCMR Movement disorders
Plasticity
Multimodal imaging | Jens Bo Nielsen
IFI, INF Spinal cord physiology
Gait
Motor learning |
Anina Rosenbaum
IFI Agency
Sensory-motor integration | Jesper Lundbye-Jensen
IFI, INF Plasticity and motor learning
Immobilisation | Tue Hvass Petersen
IFI, INF Motor coordination
Movement disorders |
Objectives
Here at DRCMR we aim at understanding the complex mechanisms that make humans able to improve and refine movements through motor learning. We have ongoing projects on how to improve methods for neurorehabilitation and studies of motor learning in relation to sport science. The group has a strong interest in examination the reorganization of motor control systems after spinal cord injury, stroke as well as in patients with movement disorders. Humans rely on visual inputs in order to control certain movement. Here we study how sensory stimuli are integrated with motor commands in order to obtain goal directed behaviour and how that can be accomplished both at a conscious and unconscious level. Finally, we are studying the complex integration of motor commands and ongoing evaluation of sensory feedback that gives rise to a feeling of ownership of movements and underlies the conscious experience of movements.
Resources
Besides the MR-facilities at DRCMR, the Sensorimotor Integration Group has acceess to a well equipped
neurophysiology lab located at Hvidovre Hospital with fMRI compatible EEG (BrainProducts), transcranial magnetic stimulation (Medtronic), neuronavigation (Localite), eyetracker (Mag Design & Engineering) and an extensive set of EMG amplifiers (custom build) and AD-converters (Cambridge Electronic Design). Furthermore, we have access to extensive TMS labs and a gait lab at the Panum Institute where detailed electrophysiological and kinematical measurement can be made.
Selected publications
Lundell H, Christensen MS, Barthelemy D, Willerslev-Olsen M, Biering-Sørensen F, Nielsen JB
Cerebral activation is correlated to regional atrophy of the spinal cord and functional motor disability in spinal cord injured individuals.
NeuroImage (In press)
Lundell H, Barthelemy D, Skimminge A, Dyrby TB, Biering-Sørensen F, Nielsen JB
Independent spinal cord atrophy measures correlate to motor and sensory deficits in individuals with spinal cord injury
Spinal Cord (In press)
Klöppel S, Mangin JF, Vongerichten A, Frackowiak RS, Siebner HR
Nurture versus nature: Long-term impact of forced right-handedness on structure of pericentral cortex and basal ganglia.
J Neurosci. 2010 30(9):3271-5.
Siebner HR;Bergmann TO;Bestmann S;Massimini M;Johansen-Berg H;Mochizuki H;Bohning DE;Boorman ED;Groppa S;Miniussi C;Pascual-Leone A;Huber R;Taylor PCJ;Ilmoniemi RJ;De Gennaro L;Strafella AP;Kähkönen S;Klöppel S;Frisoni GB;George MS;Hallett M;Brandt SA;Rushworth MF;Ziemann U;Rothwell JC;Ward N;Cohen LG;Baudewig J;Paus T;Ugawa Y;Rossini PM.
Consensus paper: Combining transcranial stimulation with neuroimaging.
Brain Stimulation 2009 2(2) 58-80
Christensen MS
Bevægelse og bevidsthed: Hvordan ved vi, at vi bevæger os?
(in: Hjernen i bevægelse (red: Bøgeskov J, Ellemann K, Nielsen JB))
HjerneForum 2009, p. 114-121
Zuur AT;Christensen MS;Sinkjaer T;Grey MJ;Nielsen JB.
Tibialis anterior stretch reflex in early stance is suppressed by repetitive TMS.
J Physiol 2009 587.8, 1669-1672
Christensen MS;Kristiansen L;Rowe JB;Nielsen JB.
Action-blindsight in healthy subjects after transcranial magnetic stimulation.
Proc Natl Acad Sci U S A 2008, 105(4), 1353-1357.
Balslev D;Braet W;McAllister C;Miall RC.
Inter-individual variability in optimal current direction for transcranial magnetic stimulation of the motor cortex.
J Neurosci Methods 2007, 162(1-2), 309-313.
Balslev D;Cole J;Miall RC.
Proprioception contributes to the sense of agency during visual observation of hand movements: evidence from
temporal judgments of action.
J Cogn Neurosci 2007, 19(9), 1535-1541.
Balslev D;Miall RC;Cole J.
Proprioceptive deafferentation slows down the processing of visual hand feedback.
J Vis 2007, 7(5), 12-17.
Christensen MS;Lundbye-Jensen J;Geertsen SS;Petersen TH;Paulson OB;Nielsen JB.
Premotor cortex modulates somatosensory cortex during voluntary movements without proprioceptive feedback.
Nat Neurosci 2007, 10(4), 417-419.
Christensen MS;Lundbye-Jensen J;Petersen N;Geertsen SS;Paulson OB;Nielsen JB.
Watching Your Foot Move--An fMRI Study of Visuomotor Interactions during Foot Movement.
Cereb Cortex 2007, 17(8), 1906-1917. Collaborators
Copenhagen Neural control of movement , University of Copenhagen (CPH-NCM)
Department of Neuroscience and pharmachology , University of Copenhagen (INF)
Department of Excercise and Sport Sciences , University of Copenhagen (IFI)
Center for research in spasticity and neurorehabilitation (CFSN)
Division of Cognitive Neuroscience , Karolinska Insituttet, Stockholm, Sweden.
Helene Elsass Center, Charlottenlund, Denmark |
