Julian Macoveanu



+45 3195 3196


Senior Researcher


Psychiatric Centre Copenhagen

Research Interests

• Systems neuroscience with a focus on risk-related decision-making and reward processing
• Multimodal mapping of the serotonergic system in the human brain
• Neuroimaging of psychiatric disorders

Research Groups

Center for Integrated Molecular Brain Imaging

Curriculum Vitae



PhD in medical sciences (Neuroscience), Karolinska Institutet, Stockholm, Sweden


Licentiate of Engineering (Computational Biology), University of Linköping, Sweden


MSc (Chemistry), Stockholm University, Sweden


2015 -

Psychiatric Centre Copenhagen, Rigshospitalet, Denmark

2006 - 2014

DRCMR Hvidovre Hospital, Denmark


Macoveanu J, Fisher PM, Madsen MK, McMahon B, Knudsen GM, Siebner HR. Bright-light intervention induces a dose-dependent increase in striatal response to risk in healthy volunteers. Neuroimage 2016. In press

Macoveanu J. Can the existing knowledge in depression treatment aid the recovery from the burnout syndrome? Acta Paediatr. 2016 In press

Miskowiak KW, Vinberg M, Glerup L, Paulson OB, Knudsen GM, Ehrenreich H, Harmer CJ, Kessing LV, Siebner HR, Macoveanu J. Neural correlates of improved executive function following erythropoietin treatment in mood disorders. Psychol Med 2016. In press

Macoveanu J, Ramsøy T, Skov M, Siebner HR, Fosgaard TR. The neural bases of framing effects in social dilemmas. J Neurosci Psychol Econ 2016. 9(1):14-28

Macoveanu J, Henningsson S, Pinborg A, Jensen P, Knudsen GM, Frokjaer VG, Siebner HR. Sex-Steroid Hormone Manipulation Reduces Brain Response to Reward. Neuropsychopharmacology 2016 41(4):1057-65

Knudsen GM et al. (2016). The Center for Integrated Molecular Brain Imaging (Cimbi) database. Neuroimage. 2016 Jan 1;124(Pt B):1213-9

Macoveanu J, Miskowiak K, Vinberg M, Kessing LV, Siebner H (2015) Healthy co-twins of patients with affective disorders show reduced risk-related activation of the insula during a monetary gambling task. J Psychiatry and Neurosci. 40(5):140220

Miskowiak KW, Vinberg M, Macoveanu J, Ehrenreich H, Køster N, Inkster B, Paulson OB, Kessing LV, Skimminge A, Siebner HR (2015). Effects of Erythropoietin on Hippocampal Volume and Memory in Mood Disorders. Biol Psychiatry. 78(4):270-7

Miskowiak KW, Glerup L, Vestbo C, Harmer CJ, Reinecke A, Macoveanu J, Siebner HR, Kessing LV, Vinberg M (2015) Different neural and cognitive response to emotional faces in healthy monozygotic twins at risk of depression. Psychol Med. 45(7):1447-58

Ramsøy T, Skov M, Macoveanu J, Siebner HR, Fosgaard TR (2014) Empathy as a neuropsychological heuristic in social decision-making. Soc Neurosci 10(2):179-91

Macoveanu J, Fisher P, Haahr M, Frokjaer V, Knudsen GM, Siebner HR (2014) Effects of selective serotonin reuptake inhibition on neural activity related to risky decisions and monetary rewards in healthy males. NeuroImage 99:434-42

Macoveanu J (2014). Serotonergic modulation of reward and punishment: evidence from pharmacological fMRI studies. Brain Research 1556:19-27

Macoveanu J, Knorr U, Skimminge A, Søndergaard MG, Jørgensen A, Fauerholdt- Jepsen M, Paulson OB, Knudsen GM, Siebner HR, Kessing LV (2013). Altered reward processing in the orbitofrontal cortex and hippocampus in healthy first- degree relatives of patients with depression. Psychol Med 44(6):1183-95

Macoveanu J, Rowe JB, Hornboll B, Elliott R, Paulson OB, Knudsen GM, Siebner HR. Serotonin 2A receptors contribute to the regulation of risk-averse decisions (2013). NeuroImage 83:35-44.

Hornboll B, Macoveanu J, Rowe JB, Elliott R, Paulson OB, Siebner HR Knudsen GM (2013). Acute 5-HT2A receptor blocking alters the processing of fearful faces in orbitofrontal cortex and amygdala. Psychopharmacology 27(10):903-14

Macoveanu J, Hornboll B, Elliott R, Paulson OB, Knudsen GM, Siebner HR. Rowe JB (2013) Serotonin 2A receptors, citalopram and tryptophan-depletion: a multimodal imaging study of their interactions during response inhibition Neuropsychopharmacol 38(6):996-1005

Macoveanu J, Rowe JB, Hornboll B, Elliott R, Paulson OB, Knudsen GM, Siebner HR (2013) Playing it safe but losing anyway - Serotonergic signaling of negative outcomes in dorsomedial prefrontal cortex in the context of risk- aversion. Eur Neuropsychopharmacol 23(8):919-30

Grady CL, Siebner HR, Hornboll B, Macoveanu J, Paulson OB, Knudsen GM (2012) Acute pharmacologically induced shifts in serotonin availability abolish emotion-selective responses to negative face emotions in distinct brain networks. Eur Neuropsychopharmacol. 23(5):368-78

Miskowiak KW, Vinberg M, Harmer CJ, Ehrenreich H, Knudsen GM, Macoveanu J, Hansen AR, Paulson OB, Siebner HR,Kessing LV (2010) Effects of erythropoietin on depressive symptoms and neurocognitive deficits in depression and bipolar disorder. Trials 11:97

Edin F., Macoveanu J., Olesen P., Tegnér J., Klingberg. J (2007) Stronger synaptic connectivity as a mechanism behind development of working memory-related brain activity during childhood. J Cogn Neurosci. 19(5):750-60.

Macoveanu J, Klingberg T, Tegnér J. (2007) Neuronal firing rates account for distractor effects on mnemonic accuracy in a visuo-spatial working memory task. Biol Cybern 96(4):407-19.

Macoveanu J, Klingberg T, Tegnér (2006) A biophysical model of multiple-item working memory: a computational and neuroimaging study. J Neuroscience 141 (3):1611-18.

Olesen P, Macoveanu J, Tegnér J, Klingberg T. (2007) Brain Activity Related to Working Memory and Distraction in Children and Adults. Cereb Cortex. 17(5):1047-54