Ellen Garde

Email

Tel.

+45 3862 2977

Position

Senior Researcher

Research Interests

Assessment of inter-individual brain aging processes, both large-scale cohort and populations studies and international multi-site cohort studies. Investigating structural, hemodynamic, and functional (cognition and physical) aspects of cerebral white matter changes (incl. small vessel disease) in normal ageing, dementia, depression, and migraine using multimodal neuroimaging techniques.

Research Groups

Aging & Dementia Group (Group Leader)
Multiple Sclerosis

Curriculum Vitae

Education

1994

Neurology, Copenhagen University Hospital, Bispebjerg; (Specialist Registrar)

1993

Neurology, Copenhagen University Hospital, Bispebjerg; (Senior House Officer)

1992

Orthopaedic Surgery, Copenhagen University Hospital, Gentofte (Senior House Officer, ATLS)

1992

Orthopaedic Surgery, Copenhagen University Hospital, Gentofte (incl.A&E) (Basic Surgical training, House Officer)

1991

Dept. of Gastroenterology, University Hospital, Herlev (incl. cardiology and A&E) (Basic Medical training, House Officer)

1989

Dept. of Paediatrics, Rigshospitalet (House Officer)

Employments

2015 - Present

Associate professor, Department of Public Health , University of Copenhagen

2009 - Present

Senior Researcher, DRCMR

2006 - 2008

Clinical Research Fellow, NMR Research Unit, Department of Inflammation, Institute of Neurology, University College London

2004 - 2006

Clinical Research Fellow, Dementia Research Centre, Institute of Neurology, University College London, UK

2002 - 2004

Honorary Clinical Research Assistant at Dementia Research Centre, Institute of Neurology, London, UK (MR-imaging, clinical trials)

2001 - 2004

Postdoc, DRCMR, Hvidovre Hospital and Memory Disorders Research Unit, Copenhagen University Hospital, Rigshospitalet (MR-imaging, cohorts)

1996 - 2001

PhD student, DRCMR (maternity leave June 1998-2000)

1994 - 1995

Research Fellow at Copenhagen University; Dept. of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital

Full CV

Publications

Gaist D*, Garde E*, Blaabjerg M, Nielsen HH, Krøigård T, Østergaard K, Møller HS, Hjelmborg J, Madsen CG, Iversen P, Kyvik KO, Siebner HR, Ashina M. Migraine with aura and risk of silent brain infarcts and white matter hyperintensities: an MRI study.  Brain. 2016 Jul;139(Pt 7):2015-23 (*shared)

Devantier TA, Nørgaard BL, Poulsen MK, Garde E, Øvrehus KA, Marwan M, Achenbach S, Dey D, Sørensen LH, Videbech P. White Matter Lesions, Carotid and Coronary Atherosclerosis in Late-Onset Depression and Healthy Controls. Psychosomatics. 2016 Jul-Aug;57(4):369-77

Sørensen PS, Sellebjerg F, Lycke J, Färkkilä M, Créange A, Lund CG, Schluep M, Frederiksen JL, Stenager E, Pfleger C, Garde E, Kinnunen E, Marhardt K; RECYCLINE Study Investigators. Minocycline added to subcutaneous interferon β-1a in multiple sclerosis: randomized RECYCLINE study. Eur J Neurol. 2016 May;23(5):861-70

Kasenburg N, Liptrot M, Reislev NL, Ørting SN, Nielsen M, Garde E, Feragen A. Training shortest-path tractography: Automatic learning of spatial priors. Neuroimage. 2016 Apr 15;130:63-76

Ratzer R, Iversen P, Börnsen L, Dyrby TB, Romme Christensen J, Ammitzbøll C, Madsen CG, Garde E, Lyksborg M, Andersen B, Hyldstrup L, Sørensen PS, Siebner HR, Sellebjerg F. Monthly oral methylprednisolone pulse treatment in progressive multiple sclerosis. Mult Scler. 2016 Jun;22(7):926-34

Voldsgaard A, Bager P, Garde E, Åkeson P, Leffers A, Madsen C, Kapel C, Roepstorff A, Thamsborg S, Melbye M, Siebner H, Søndergaard H, Sellebjerg F, Sørensen PS. Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect. Mult Scler. 2015 Nov;21(13):1723-9.

Gauthier CJ, Lefort M, Mekary S, Desjardins-Crépeau L, Skimminge A, Iversen P, Madjar C, Desjardins M, Lesage F, Garde E, Frouin F, Bherer L, Hoge RD. Hearts and minds: linking vascular rigidity and aerobic fitness with cognitive aging. Neurobiol Aging. 2015 Jan;36(1):304-14.

Langevad L, Madsen CG, Siebner H, Garde E. [MRI of the pineal gland.] Ugeskr Laeger. 2014 Nov 10;176(46)

Lyksborg M, Siebner HR, Sørensen PS, Blinkenberg M, Parker GJ, Dogonowski AM, Garde E, Larsen R, Dyrby TB. Secondary progressive and relapsing remitting multiple sclerosis leads to motor-related decreased anatomical connectivity. PLoS One. 2014 Apr 18;9(4)

Romme Christensen J, Ratzer R, Börnsen L, Lyksborg M, Garde E, Dyrby TB, Siebner HR, Sorensen PS, Sellebjerg F. Natalizumab in progressive MS: Results of an open-label, phase 2A, proof-of-concept trial. Neurology. 2014 Mar 28

Anstey KJ, Sargent-Cox K, Garde E, Cherbuin N, Butterworth P. Cognitive Development Over 8 Years in Midlife and Its Association With Cardiovascular Risk Factors. Neuropsychology. 2014 Mar 17.

Simonsen AH, Mattila J, Hejl AM, Garde E, van Gils M, Thomsen C, Lötjönen J, Soininen H, Waldemar G. Application of the PredictAD Decision Support Tool to a Danish Cohort of Patients with Alzheimer's Disease and Other Dementias.Dement Geriatr Cogn Disord. 2013.Oct 26;37(3-4):207-213.

Macfarlane MD, Looi JC, Walterfang M, Spulber G, Velakoulis D, Styner M, Crisby M, Orndahl E, Erkinjuntti T, Waldemar G, Garde E, Hennerici MG, Bäzner H, Blahak C, Wallin A, Wahlund LO; LADIS Study Group. 2013 Shape Abnormalities of the Caudate Nucleus Correlate with Poorer Gait and Balance: Results from a Subset of the LADIS Study. Am J Geriatr Psychiatry S1064-7481(13)00229-7

Macfarlane MD, Looi JC, Walterfang M, Spulber G, Velakoulis D, Crisby M, Orndahl E, Erkinjuntti T, Garde E, Waldemar G, Wallin A, Wahlund LO; LADIS Study Group. 2013. Executive dysfunction correlates with caudate nucleus atrophy in patients with white matter changes on MRI: A subset of LADIS. Psychiatry Res. 30;214(1):16-23

Lund H, Krakauer M, Skimminge A, Sellebjerg F, Garde E, Siebner HR, Paulson OB, Hesse D, Hanson LG. 2013. Blood-brain barrier permeability of normal appearing white matter in relapsing-remitting multiple sclerosis. PLoS One;8(2) [Epub ahead of print]

Habekost T, Vogel A, Rostrup E, Bundesen C, Kyllingsbaek S, Garde E, Ryberg C, Waldemar G 2013 Visual processing speed in old age.Scand J Psychol. 54(2):89-94.

Reinhard H, Garde E, Skimminge A, Akeson P, Ramsøy T, Winther K, Parving HH, Rossing P, Jacobsen PK. 2012. Plasma NT-proBNP and white matter hyperintensities in type 2 diabetic patients. Cardiovasc Diabetol 3;11(1):119.*

Jokinen H, Frederiksen KS, Garde E, Skimminge A, Siebner H, Waldemar G, Ylikoski R, Madureira S, Verdelho A, van Straaten EC, Barkhof F, Fazekas F, Schmidt R, Pantoni L, Inzitari D, Erkinjuntti T. 2012. Callosal tissue loss parallels subtle decline in psychomotor speed. a longitudinal quantitative MRI study. The LADIS Study. Neuropsychologia. Jun;50(7):1650-5. 

Salem LC, Hejl AM, Garde E, Leffers AM, Paulson OB, Waldemar G. 2011. White matter hyperintensities and prepulse inhibition in a mixed elderly population. Psychiatry Res. 30;194(3):314-8.

Frederiksen KS, Garde E, Skimminge A, Barkhof F, Scheltens P, van Straaten E, Fazekas F, Baezner H, Verdelho A, Ferro JM, Erkinjuntti T, Jokinen H,  Wahlund L-O, O’Brien J, Basile AM, Pantoni L, Inzitari D,  Waldemar G on behalf of the LADIS study group. 2011. Corpus Callosum Tissue Loss and Development of Motor and Global Cognitive Impairment: The LADIS Study Dement Geriatr Cogn Disord, 32(4):279-86

Frederiksen KS, Garde E, Skimminge A, Ryberg C, Rostrup E, Baaré WF, Siebner HR, Hejl AM, Leffers AM, Waldemar G. 2011. Corpus callosum atrophy in patients with mild Alzheimer's disease. Neurodegener Dis.;8(6):476-82.*

Ravnborg M, Sørensen PS, Andersson M, Celius EG, Jongen PJ, Elovaara I, Bartholomé E, Constantinescu CS, Beer K, Garde E, Sperling B. Methylprednisolone in combination with interferon beta-1a for relapsing-remitting multiple sclerosis (MECOMBIN study): a multicentre, double-blind, randomised, palcebo-controlled, parallel-group trial 2010 Lancet Neurol ;9(7):672-80.

Dyrby TB, Baaré WF, Alexander DC, Jelsing J, Garde E, Søgaard LV. 2010. An ex vivo imaging pipeline for producing high-quality and high-resolution diffusion-weighted imaging datasets. Hum Brain Mapp. 32(4):544-63.

Barnes J, Mitchell LA, Kennedy J, Bastos-Leite AJ, Barker S, Lehmann M, Nordstrom RC, Frost C, Smith JR, Garde E, Rossor MN, Fox NC. 2010 Does registration of serial MRI improve diagnosis of dementia? Neuroradiology. Feb 27. 52(11):987-95.*

Høgh P, Garde E, Mortensen EL,  Jørgensen OS, Krabbe K, Waldemar G. 2007. The apolipoprotein E 4-allele and arterial hypertension are associated with increased risk of cerebral MRI white matter hyperintensities. Acta Neurol Scand:115(4);248-53*

Sneller BI , Garde E , Atkinson D, Batchelor P, Fox NC, Hill DLG 2006. Flow artifacts in MR imaging for Alzheimer’s detection and progression. Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2(3) (Suppl.): S322-S323

Camara-Rey O, Sneller BI, Ridgway GR, Garde E, Fox NC, Hill DL.  2006 Simulation of acquisition artifacts in MR scans: effect on automatic measures of brain atrophy Med Image Comput Assist Interv (9):272-80.

Garde E, Mortensen EL, Rostrup E, Paulson OB. 2005. Decline in intelligence is associated with progression in white matter hyperintensities. JNNP;76(9):1289-91*

Marstrand JR, Garde E, Rostrup E, Ring P, Rosenbaum S, Mortensen EL, Larsson HBW. 2002. Cerebral Perfusion and Cerebrovascular Reactivity is Reduced in White Matter Hyperintensities Stroke; 33(4):972-6*

Marstrand JR, Rostrup E, Rosenbaum S, Garde E, Larsson HBW. 2001. Cerebral Hemodynamic changes measured by Gradient-Echo or Spin-Echo bolus tracking and its correlation to changes in ICA blood flow measured by Phase-Mapping MRI. J Magn Reson Imaging;14(4): 391-400*

Garde E, Mortensen EL, Krabbe K, Rostrup E, Larsson HBW. 2000. Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study. The Lancet; 356: 628-33*

Garde E, Iversen L. 1997 Prevention of Brain Diseases (Invited review). Ugeskr Læger; 159: 7475-78

Garde E, Lassen NA 1995. Stroke-in-Progression. Ugeskr Læger; 157: 4234-9*

Olsen TS, Jørgensen HS, Garde E, Lassen NA 1995. Treatment of High Blood Pressure in Patients with Acute Stroke. Ugeskr Læger ; 157: 3623-5

Garde E, Jørgensen HS, Olsen TS, Lassen NA 1995. Reducing Hypertension may Worsen Symptoms in Acute Stroke. Ugeskr Læger; 157: 3630-1

Garde E, Micic S, Knudsen K, Angelo HR, Wulf  HC.1994. 8-Methoxypsoralen Increases Daytime Plasma Melatonin Levels in Humans through Inhibition of Metabolism. Photochemistry and Photobiology 5:475-80

Helweg-Larsen K, Garde E 1993. Sudden Natural Death in Childhood. Acta Paediatrica Scandinavia; 82:975-8

Illum N, Møller M, Garde E 1993 Physiopathologic Mechanisms behind Eye Symptoms in Primary Tumors of the Pineal Body. Ugeskr Læger; 155:212-5