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Education, Training, Clinical appointments
1989-1995
Residency in Internal Medicine (Trier, Germany), Neurosurgery (Koblenz, Germany) and Neurology (Paderborn, Germany)
1995-2002
Clinical Research Fellow, Dept. of Neurology, Munich University of Technology, Germany
2002 - Aug. 2008
Consultant, Department of Neurology, Christian-Albrechts-Univ. Kiel, Germany
Sept. 2008-Now
Consultant (Overlæge), DRCMR/MR-Department, Hvidovre University Hospital, Hvidovre, Denmark
Feb. 2009-Now
Head of Research, DRCMR/MR-Department, Hvidovre University Hospital, Hvidovre, Denmark
Oct. 2010-Now
Head of DRCMR/MR-Department, Hvidovre University Hospital, Hvidovre, Denmark
Research Experience / Academic Appointments
1991
MD (Dr. med.), Medical faculty, Saarland University, Germany
2000-2002
Postdoc Positions at Sobell Department, Institute of Neurologie London,UK and the Department of Brain Pathophysiology, Kyoto University, Japan
2002-2008
Principle Invstigator for Neuroimmaging of Motor Control and Movement Disorders, Brain Imaging Center “NeuroImage-Nord”, Hamburg-Kiel-Lübeck 2003 Privatdozent (Lecturer) at the Department of Neurology of the Medical Faculty of the Christian-Albrechts-University Kiel
2004-2008
Full professor for „Functional Immaging and Movement Disorders“ at the Christian-Albrechts-University Kiel
Feb. 2009-Now
Full professor for "Functional brain imaging", Dept. of Neurology, Psychiatry and Senses, Faculty of Health Sciences, University of Copenhagen
Current areas of research
• Sensorimotor control of actions and movement disorders (ContAct)
• Linking functional neuroimaging with trait markers of serotonergic neurotransmission
• Functional neuroimaging of neuropsychiatic disorders
• Multimodal in vivo mapping (fMRI, EEG, TMS, PET) of human brain networks
• Characterization of functional brain states with non-invasive brain mapping techniques
• Probing cortico-cortical and cortico-subcortical connectivity (DTI, multi-site TMS, fMRI)
• Modifying brain states with transcranial neurostimulation (TMS, TDCS)
• Genetically informed neuroimaging
Research tools
Functional (fMRI, PET and EEG) and structural brain mapping (VBM of T1w-MRI, DWI) with a
focus on multimodal integration (EEG-fMRI, TMS-fMRI)
Psychophysical measurements in conjunction with neuronavigated TMS (virtual lesion technique)
Multi-site TMS to probe cortico-cortical connectivity
Inducing brain reorganizatiaon with rTMS and TDCS
Research management
Head of the ContAct (Control of Action) research group supported by an Excellence Grant of
Lundbeckfonden (3 Mill. Euro; 2011-2015)
Steering group member of the Center for Integrated Molecular Brain Imaging (CIMBI) (2009-)
Head of Research, Danish Research Centre for Magnetic Resonance (~ 25 Phd students, ~ 15
PostDocs)
Research principal in the field of “Neuroimaging of Motor Control and Movement Disorders” at the
Brain Imaging Center “NeuroImage-Nord”, Hamburg-Kiel-Lübeck, Germany (2002-2008)
Research funding
22 research grants from various funding sources from 1997-2010 (total funding: > 10 Mill. €)
including project grants from the German Research Council (DFG, 4 grants), Danish Research
Council for Heath and Disease (FSS, 2 grants), German Ministery for Education and Research
(BMBF, 3 grants), VolkswagenStiftung (2 grants) and Lundbeckfonden (2 grants)
Benign Essential Blepharospasm Research Foundation, Jeppe Juhl og Hustru Ovita Juhl’s
Mindelegat 2008, Dansk Scleroseforeningen, Henry Hansen og Hustrus Legat 2009
Donation from The John and Birthe Meyer Foundation (~ 5.2 million €) for an ultra-high field
MRI facility at DRCMR, Hvidovre Hospital (Recipients: T. Mogensen, H.R. Siebner). This
donation follows a donation of 3.6 million € from the Danish Research Councils. Together they
provide the funding needed for establishing the 7T MRI facility, which will be the first in the Nordic
countries.
Editorial board member of
NeuroImage and Brain Stimulation, Member of the Scientific advisory
Board of the Luria Institut, Konstanz, Germany and Skleroseforeningen, Danmark
2000-2002 Post-doctoral fellow, Institute of Neurology, UCL, London,UK (educational grant)
2002 Visiting Professor, Kyoto University, Japan
2003 Oppenheim-Prize, German Dystonia Research Foundation
2009 Richard Jung Prize, German Society for Clinical Neurophysiology
2010 Lundbeck Foundation Grant of Excellence: Mapping, modulation and modelling the CONTrol of ACTions (ContAct)
Publications
196 peer-reviewed publications (186 publications in English)
168 original papers and 28 reviews, 37 papers have been cited 37 times or more (Hirsch index: 37)
Cumulative impact factor (IF): 933, Mean IF: 5.02 (based on publications in English)
Cumulative sum of scientific citations: 4250t)
25 selected publications (2003-2011)
1. Lee L, Siebner HR, Rowe JB, Rizzo V, Rothwell JC, Frackowiak RS, Friston KJ. (2003)
Acute remapping within the motor system induced by low-frequency repetitive transcranial
magnetic stimulation. J Neurosci 23:5308-5318.
2. Siebner HR, Lang N, Rizzo V, Nitsche MA, Paulus W, Lemon RN, Rothwell JC (2004)
Preconditioning of low-frequency repetitive transcranial magnetic stimulation with transcranial
direct current stimulation: evidence for homeostatic plasticity in the human motor cortex. J Neurosci 24:3379-3385.
3. Buhmann C, Binkofski F, Klein C, Büchel C, van Eimeren T, Erdmann C, Hedrich K,
Kasten M, Hagenah J, Deuschl G, Pramstaller PP, Siebner HR (2005) Motor reorganization in
asymptomatic carriers of a single mutant Parkin allele: a human model for presymptomatic
parkinsonism. Brain 128: 2732-2746.
4. Quartarone A, Rizzo V, Bagnato S, Morgante F, Sant’Angelo A, Romano M, Crupi D,
Girlanda P, Rothwell JC, Siebner HR (2005) Homeostatic-like plasticity of the primary motor hand
area is impaired in focal hand dystonia. Brain 128:1943-1950.
5. Bäumer T, Bock F, Koch J, Lange R, Rothwell JC, Siebner HR, Münchau A (2006)
Magnetic stimulation of human premotor or motor cortex produces interhemispheric facilitation
through distinct pathways. J Physiol 572:857-868.
6. Peller M, Zeuner KE, Munchau A, Quartarone A, Weiss M, Knutzen A, Hallett M, Deuschl
G, Siebner HR (2006) The basal ganglia are hyperactive during the discrimination of tactile stimuli in writer´s cramp. Brain 129:2697-2708.
7. Ponseti J, Bosinski HA, Wolff S, Peller M, Jansen O, Mehdorn HM, Büchel C, Siebner HR
(2006) A functional endophenotype for sexual orientation in humans. NeuroImage 33:825-833.
8. van Eimeren T, Wolbers T, Münchau A, Büchel C, Weiller C, Siebner HR (2006)
Implementation of visuospatial cues in response selection. NeuroImage 29:286-294.
9. Klöppel S, Vongerichten A, van Eimeren T, Frackowiak RSJ, Siebner HR (2007) Can lefthandedness be switched? – insights from an early switch of handwriting. J Neurosci 27:7847-7853.
10. Bergmann TO, Mölle M, Marshall L, Kaya-Yildiz L, Born J, Siebner HR (2008) A local
signature of LTP- and LTD-like plasticity in human NREM sleep. Eur J Neurosci 27:2241-2249.
11. Kloeppel S, Bäumer T, Kroeger J, Koch MA, Büchel C, Münchau A, Siebner HR (2008) The
cortical motor threshold reflects microstructural properties of cerebral white matter. NeuroImage 40:1782-1791.
12. Moeller F, Siebner HR, Wolff S, Muhle H, Boor R, Granert O, Jansen O, Stephani U,
Siniatchkin M (2008) Changes in activity of striato-thalamo-cortical network precede generalized spike wave discharges. NeuroImage 39:1839-1849.
13. Kirov R, Weiss C, Siebner HR, Born J, Marshall L (2009) Wake slow oscillation electrical
brain stimulation promotes EEG theta activity and memory encoding. Proc Natl Acad Sci U S A
106:15460-15465.
14. Moeller F, Siebner HR, Ahlgrimm N, Wolff S, Muhle H, Granert O, Boor R, Jansen O,
Gotman J, Stephani U, Siniatchkin M (2009) fMRI activation during spike and wave discharges
evoked by photic stimulation. Neuroimage 48:682-695.
15. Ponseti J, Granert O, Jansen O, Wolff S, Mehdorn HM, Bosinski HA, Siebner HR (2009)
Assessment of sexual orientation using the hemodynamic brain re-sponse to visual sexual stimuli. J Sex Med 6:1628-1634.
16. Thomalla G, Siebner HR, Jonas M, Bäumer T, Biermann-Ruben K, Hummel F, Gerloff
Müller-Vahl C, Schnitzler A, Orth M, Münchau A (2009) Structural changes in the somatosensory
system correlate with tic severity in Gilles de la Tourette syndrome. Brain 132:765-777.
17. Van Nuenen BFL, Weiss MM, Bloem BR, Reetz K, van Eimeren T, Lohmann K, Hagenah J,
Pramstaller PP, Binkofski F, Klein C, Siebner HR (2009) Heterozygous carriers of a Parkin or
PINK1 mutation share a common functional endophenotype. Neurology 72:1041-1047.
18. Weiss MM, Wolbers T, Peller M, Witt K, Marshall L, Buchel C, Siebner HR (2009) Rotated
alphanumeric characters do not automatically activate frontoparietal areas subserving mental
rotation. NeuroImage 44:1063-1073.
19. Hartwigsen G, Baumgaertner A, Price CJ, Koehnke M, Ulmer S, Siebner HR (2010)
Phonological decisions require both the left and right supramarginal gyri. Proc Natl Acad Sci U S A. 107:16494-16499.
20. Helmich RC, Siebner HR, Giffin N, Bestmann S, Rothwell JC, Bloem BR (2010) The
dynamic regulation of cortical excitability is altered in episodic ataxia type 2 Brain 133:3519-3529.
21. Klöppel S, Mangin JF, Vongerichten A, Frackowiak RSJ, Siebner H (2010) Nurture versus
nature: long-term impact of forced right-handedness on structure of pericentral cortex and basal ganglia. J. Neurosci 30:3271-3275.
22. Ward NS, Bestmann S, Hartwigsen G, Weiss MM, Christensen LOD, Frackowiak RSJ,
Rothwell JC, Siebner HR (2010) Low-frequency transcranial magnetic stimulation over left dorsal
premotor cortex improves the dynamic control of visuospatially cued actions. J Neurosci 30:9216- 9223.
23. Granert O, Peller M, Gaser C, Groppa S, Hallett M, Knutzen A, Deuschl G, Zeuner KE,
Siebner HR (2011) Manual activity shapes structure and function in contralateral human motor hand area. NeuroImage 54:32-41.
24. Lou AR, Madsen KH, Paulson OB, Olsen Julian H, Prause JU, Siebner HR, Kjær TW (2011)
Monocular visual deprivation suppresses excitability in adult human visual cortex. Cereb Cortex in press.
25. Kassuba T, Klinge C, Höling C, Menz MM, Ptito M, Röder B, Siebner HR (2011) The l
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