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Lise Vejby Søgaard
Research group leader
DRCMR
Disease progression
Cell metabolism using HP13C
Rapid metabolic imaging of HP13C
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Brian Villumsen Broberg
DRCMR
Pharmacological brain activation in schizophrenia
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Sadia Asghar Butt
DRCMR
Metabolism of breast cancer
disease using HP13C
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Henrik Lundell
DRCMR, IFI
Spinal cord imaging
Diffusion MRI acquisistion
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Peter Magnusson
DRCMR
Cell metabolism using HP13C
Rapid metabolic imaging of HP13C
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Anders Skjolding
DRCMR
Aquaporins and hydrocephalus
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Objectives:
The preclinical research group aim for better understanding and characterization of disease progression. Models of common major diseases are used for longitudinal investigations, including effects of treatment.
Focus areas are in vivo studies of cell metabolism using hyperpolarized 13C enriched substances in mammary cancer and ischemic heart disease, and ex vivo studies of brain tissue microstructure and connectivity using diffusion imaging. In addition pharmacologically induced brain activation in a schizophrenia model is investigated to provide basis for development of new drugs for this disabling disorder. Finally, the possible correlation between aquaporin expression and periventricular diffusion in hydrocephalus is investigated.
Resources:
The group uses a 4.7 T pre-clinical Varian MR-scanner with newly installed strong gradients for the studies. A range of RF coils are available including special coils for 13C and other special nuclei. For preparation the group has a well equipped laboratory and MR compatible physiological monitoring equipment is available.
Selected publications:
Madsen KS, Holm DA, Søgaard LV, Rowland IJ. Effect of paramagnetic manganese cations on (1)H MRS of the
brain. NMR Biomed. 2008 Nov;21(10):1087-93.
Brandt CT, Simonsen H, Liptrot M, Søgaard LV, Lundgren JD, Østergaard C, Frimodt-Møller N, Rowland IJ. In vivo study of experimental pneumococcal meningitis using magnetic resonance imaging. BMC MEDICAL IMAGING 2008, 8:1. doi:10.1186/1471-2342-8-1
Golman K, Petersson JS, Magnusson P, Johansson E, Åkeson P, Chai CM, Hansson G, Månsson S
Cardiac metabolism measured noninvasively by hyperpolarized 13C MRI
Magn. Reson. Med. 59: 1005-1013, 2008
Dyrby TB, Søgaard LV, Parker GJ, Alexander DC, Lind NM, Baaré WF, Hay-Schmidt A, Eriksen N, Pakkenberg B, Paulson OB, Jelsing J. Validation of in vitro probabilistic tractography. NEUROIMAGE 37(4):1267-77 OCT 2007
Magnusson P, Johansson E, Månsson S, Petersson JS, Chai CM, Hansson G, Golman K
Passive catheter tracking during interventional MRI using hyperpolarized 13C
Magn. Reson. Med. 57(6):1140-1147, 2007
Collaborators:
Bartholin Institute, Copenhagen Biocenter
Department of Neurosurgery, Copenhagen University Hospital Rigshospitalet
Department of Pathology, Copenhagen University Hospital Hvidovre
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