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Objectives:
The Aging and Dementia group focuses on research into global and regional brain atrophy as well as vascular changes in ageing populations and individuals at risk of cognitive impairment and degenerative disease. Our current projects focus on the impact of changes in the white matter, in particular how white matter lesions and corpus callosum atrophy affect the structural and functional connectivity in the brain and relate to cognitive function and morbidity in aging, diabetes and dementia. Advanced data analysis approaches such as MR brain segmentation, tractography and shape analysis are used to link complex MR data with functional and biological measures to identify MR markers for early screening and identification of associated risk and protective factors.
Resources:
Besides having access to the highly qualified clinical MR expertise at the DRCMR MR clinic the Aging and Dementia group participate in the implementation of advanced data processing techniques developed by other groups at the DRCMR as well as at the Danish Technical University (DTU).
Selected publications:
Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort. Inzitari D, Pracucci G, Poggesi A, Carlucci G, Barkhof F, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Hennerici M, Langhorne P, O'Brien J, Scheltens P, Visser MC, Wahlund LO, Waldemar G, Wallin A, Pantoni L; LADIS Study Group. BMJ 2009 Jul 6;339
The apolipoprotein E ε4-allele and arterial hypertension are associated with increased risk of cerebral MRI white matter hyperintensities. P Høgh, E Garde, EL Mortensen, OS Jørgensen, K Krabbe, G Waldemar. Acta Neurol Scand 2007 April; 115(4);248-53
Decline in intelligence is associated with progression in white matter hyperintensities.
E Garde, EL Mortensen , E Rostrup, OB Paulson.
JNNP 2005 Sep;76(9):1289-91
Cerebral Perfusion and Cerebrovascular Reactivity is Reduced in White Matter Hyperintensities. JR Marstrand, E Garde, E Rostrup, P Ring, S Rosenbaum, EL Mortensen, HBW Larsson.
Stroke 2002; 33(4):972-6
Cerebral Hemodynamic changes measured by Gradient-Echo or Spin-Echo bolus tracking and its correlation to changes in ICA blood flow measured by Phase-Mapping MRI. JR Marstrand, E Rostrup, S Rosenbaum, E Garde, HBW Larsson. J Magn Reson Imaging 2001;14(4): 391-400
Relation between age-related decline in intelligence and cerebral white-matter hyperintensities in healthy octogenarians: a longitudinal study.
E Garde, EL Mortensen, K Krabbe, E Rostrup, HBW Larsson.
The Lancet 2000; 356: 628-33
Collaborators:
Memory Disorders Research Group, Rigshospitalet
PET Center, Rigshospitalet,
Steno Diabetes Center,
Danish Technical University (DTU).
LADIS (“Leukoaraiosis and Disability in the Elderly”), a multisite investigation by European Union collaborators.
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